New antibody fragments light up tumors in early imaging trial

NCT ID NCT06645808

Recruiting now Knowledge-focused Sponsor: Var2 Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial is testing two new antibody fragments that are designed to attach to a sugar molecule found on many solid tumors. The fragments are labeled with a radioactive tracer so they can be seen on PET/CT scans. The study aims to see where these fragments go in the body, how safe they are, and whether they can help spot tumors more clearly. About 32 adults with various solid tumors will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 89Zr-DFO-N-Suc-F8scFv and 89Zr-DFO-N-Suc-C9scFv (radiolabeled antibody fragments)
What this could lead to: If successful, this could pave the way for better imaging and targeted treatments for many solid tumor types.
What could go wrong: This is a very early phase 0 trial with only 32 participants, so results may not apply broadly. The main goal is imaging, not treatment, so direct patient benefit is unlikely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bone sarcoma breast cancer breast carcinoma breast neoplasm carcinoma of esophagus chondrosarcoma colon carcinoma colonic neoplasm Esophageal Neoplasms exocrine pancreatic carcinoma gastric carcinoma gastric neoplasm glioblastoma head and neck squamous cell carcinoma lung carcinoma lung neoplasm neoplasm non-small cell lung carcinoma osteosarcoma pancreatic neoplasm rectal carcinoma rectal neoplasm sarcoma soft tissue sarcoma Squamous Cell Carcinoma of Head and Neck urinary bladder carcinoma Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLADDER CARCINOMA BREAST CANCER CHONDROSARCOMA COLON CARCINOMA ESOPHAGEAL CARCINOMA GASTRIC CARCINOMA GLIOBLASTOMA HEAD AND NECK SQUAMOUS CELL CARCINOMA LUNG CARCINOMA OSTEOSARCOMA PANCREAS CARCINOMA RECTAL CARCINOMA SOFT TISSUE SARCOMA (STS) SOLID TUMOR

Contacts and locations

Locations

University Medical Center Groningen (UMCG)
RECRUITING

Groningen, Provincie Groningen, 9713GZ, Netherlands

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