CHONDROSARCOMA

This study offers expanded access to an experimental treatment called DNG64-CAR-V for people with advanced pancreatic cancer, sarcoma, or breast cancer. Up to 40 patients will receive the therapy intravenously or directly into tumors, alone or with other approved cancer drugs. Th…

This early-phase study tests a new drug called IACS-6274, given alone or with other medicines, in people with advanced solid tumors (like certain melanomas, ovarian, and uterine cancers). The main goal is to find the safest dose and understand side effects. About 54 adults will t…

This study compares carbon ion therapy, surgery, and proton therapy for people with pelvic bone sarcomas (a type of cancer). The goal is to see which treatment provides better disease control and fewer side effects, and to measure quality of life after treatment. About 72 partici…

This study tests whether taking regorafenib for up to 12 months after initial treatment can delay or prevent bone sarcoma from coming back. About 168 patients with various bone sarcomas will be randomly assigned to receive the drug or just be monitored. The goal is to see if the …

This study is testing a shorter, more intense schedule of proton beam radiation therapy for people with rare, slow-growing tumors at the base of the skull called chordomas and chondrosarcomas. The goal is to see if giving the total radiation dose in just 5 sessions (or 27 for som…

This study looks at whether using 3D printed models of a patient's bones helps surgeons plan and perform tumor removal surgery. About 150 people with bone tumors will be randomly assigned to have their surgeon use either 3D models plus regular scans, or just scans alone. The main…

This study looks at how well people with bone cancer follow a personalized exercise program at home after having surgery to remove a tumor from their leg. About 50 patients aged 12 and older will track their daily exercises for six months. The goal is to understand what helps or …

This study follows 300 people who had surgery to remove bone tumors and then had reconstruction using bone grafts or artificial parts. Researchers will measure how well the bone heals and how much function patients regain over 3 years. The goal is to better understand recovery af…

This study is testing whether a new radioactive imaging agent can safely and clearly show tumors in people with many types of solid cancers. About 32 adults will receive a single injection of the agent and then have PET/CT scans to see where it goes in the body. The goal is to le…