CHONDROSARCOMA

This study tests a virus called AdAPT-001 that is injected directly into tumors to kill cancer cells. It is for adults with advanced solid tumors that have not responded to standard treatments. The trial will check if the virus is safe and whether it works better when combined wi…

This study tests whether combining two drugs, lenvatinib and pembrolizumab, can safely shrink or control advanced soft tissue sarcomas that have spread or can't be removed by surgery. About 52 adults with specific sarcoma types will receive the combination. The goal is to measure…

This study tests whether the drug AG-120 can safely slow or stop the growth of a rare bone cancer called chondrosarcoma that has a specific IDH1 gene mutation. Six adults with advanced or recurrent grade 2 or 3 chondrosarcoma will receive the drug. The main goal is to see how lon…

This early-stage study tests an oral drug called LY3410738 in people with advanced solid tumors (like bile duct cancer, cartilage cancer, or brain tumors) that have specific IDH1 or IDH2 mutations. The main goal is to find a safe dose and see if the drug can shrink tumors. About …

This phase 2 trial is testing whether proton beam therapy, a precise form of radiation, can control skull base chondrosarcoma after surgery. Fifteen participants who have had maximal surgical removal of their tumor will receive daily proton treatments for about 7 weeks. The study…

This phase 1b trial is testing whether giving zoledronic acid, a drug usually used for bone thinning, before surgery can help people with chondrosarcoma, a rare bone cancer. Seventeen adults with any grade of the disease that can be surgically removed will receive the drug and th…

This phase 2 trial tests whether combining NKTR-214 and nivolumab can shrink or control advanced sarcoma that has spread. About 88 people aged 12 and older with certain sarcoma types will receive both drugs every three weeks. The main goal is to see how many patients have their t…

This study follows 400 patients for two years after they have endoscopic endonasal skull base surgery (surgery through the nose to reach the base of the skull). The goal is to measure their quality of life and nose function using standard questionnaires. It does not test a new tr…

This study gathers information from 77 Italian patients with a rare, low-grade bone tumor called clear cell chondrosarcoma. Researchers will review medical records, imaging, and tissue samples to find patterns that might predict whether the tumor will come back or spread. The goa…