CHONDROSARCOMA

This study is testing if taking a drug called regorafenib for up to a year can help prevent bone cancers (sarcomas) from returning after patients finish their initial chemotherapy and surgery. It will compare patients who take the drug to those who receive standard monitoring wit…

This study aims to understand how well patients recover function and how their bones heal after surgery to remove bone tumors. Researchers will follow 300 patients for three years after their reconstructive surgery, which may use bone grafts or artificial devices. The goal is to …

This is a first-in-human study to find a safe dose of a new oral drug called IACS-6274. It will be tested alone and in two different drug combinations in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check the safety …

This program provides access to an experimental treatment called DNG64-CAR-V for patients with advanced pancreatic cancer, sarcoma, or breast cancer who have no other effective options left. The treatment uses a specially engineered virus designed to target and kill cancer cells …

This trial is testing a shorter, more convenient proton therapy schedule for people with rare, slow-growing tumors at the base of the skull called chordomas and chondrosarcomas. Instead of the standard treatment lasting many weeks, this approach delivers the radiation in just 5 s…

This study compares three different approaches for treating pelvic bone cancers (sarcomas) to see which one works best. Researchers are testing carbon ion radiation therapy against traditional surgery and proton radiation therapy. They want to find out which treatment gives patie…

This study is testing whether 3D printed models of a patient's bones help surgeons plan tumor removal surgeries better than standard medical images alone. About 150 people with bone-invading tumors like sarcoma will be randomly assigned to have their surgery planned with a 3D mod…

This early study aims to see how two new radioactive tracers travel through the body and gather in tumors. Researchers will give a single, tiny dose of one tracer to up to 32 patients with various solid tumors and then use PET/CT scans to track where it goes. The main goal is to …

This study aims to understand how well patients follow a personalized home exercise program after major leg surgery for bone cancer. Researchers will track 50 patients for six months to see how consistently they do their exercises and what factors might influence their commitment…