New gene therapy offers hope for advanced cancers

NCT ID NCT04091295

AVAILABLE Disease control Sponsor: Aveni Foundation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This expanded access program provides DNG64-CAR-V, a gene therapy, to patients with advanced pancreatic cancer, sarcoma, or breast cancer who have exhausted standard treatments. The therapy is given intravenously or directly into tumors, alone or with other cancer drugs. Early studies suggest it may stabilize or shrink tumors without severe side effects like bone marrow suppression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: DNG64-CAR-V (a gene therapy vector that targets cancer cells)
What this could lead to: If it works, this could provide a new treatment option for people with advanced cancers that have not responded to standard therapies.
What could go wrong: This is an expanded access program, not a controlled trial, so results are uncertain. Tumors may appear to grow before shrinking (pseudoprogression), and not all patients will benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast carcinoma breast neoplasm chondrosarcoma chordoma glioblastoma malignant pancreatic neoplasm malignant peripheral nerve sheath tumor neurofibrosarcoma non-small cell lung carcinoma osteosarcoma ovarian cancer ovarian carcinoma pancreatic neoplasm prostate cancer sarcoma soft tissue sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA OF BREAST CHONDROSARCOMA CHORDOMA MPNST (MALIGNANT PERIPHERAL NERVE SHEATH TUMOR) OSTEOSARCOMA PANCREATIC CANCER SARCOMA SINGLE PATIENT IND FOR GLIOBLASTOMA, OVARIAN CARCINOMA, NON-SMALL CELL LUNG CANCER , PROSTATE CANCER SOFT TISSUE SARCOMA

Contacts and locations

Locations

Sarcoma Oncology Research Center, LLC
AVAILABLE

Santa Monica, California, 90403, United States

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