Cancer-Killing virus injected directly into tumors shows promise in Mid-Stage trial

NCT ID NCT04673942

Ongoing Disease control Sponsor: EpicentRx, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a virus called AdAPT-001 that is injected directly into tumors to kill cancer cells. It is for adults with advanced solid tumors that have not responded to standard treatments. The trial will check if the virus is safe and whether it works better when combined with another immune-boosting drug.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AdAPT-001 (an oncolytic virus injected directly into tumors), sometimes combined with a checkpoint inhibitor drug
What this could lead to: If it works, this could offer a new treatment option for people with advanced solid tumors that have stopped responding to standard therapies.
What could go wrong: This is a mid-stage trial with only 140 participants, so results may not apply to everyone. The virus injection can cause side effects like fever or tumor pain, and the treatment may not shrink tumors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adenoviridae infectious disease cancer chondrosarcoma neoplasm sarcoma soft tissue sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER CHONDROSARCOMA NEOPLASMS SARCOMA SARCOMA,SOFT TISSUE SOLID TUMOR, ADULT

Contacts and locations

Locations

California Cancer Associates for Research and Excellence, cCARE

San Marcos, California, 92069, United States
City of Hope

Duarte, California, 91010, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
MD Anderson Cancer Center

Houston, Texas, 77030, United States
Mary Crowley Cancer Research

Dallas, Texas, 75230, United States
Providence Saint John's Health Center

Santa Monica, California, 90404, United States

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