Cancer-Killing virus injected directly into tumors shows promise in Mid-Stage trial
NCT ID NCT04673942
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a virus called AdAPT-001 that is injected directly into tumors to kill cancer cells. It is for adults with advanced solid tumors that have not responded to standard treatments. The trial will check if the virus is safe and whether it works better when combined with another immune-boosting drug.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
AdAPT-001 (an oncolytic virus injected directly into tumors), sometimes combined with a checkpoint inhibitor drug
What this could lead to
If it works, this could offer a new treatment option for people with advanced solid tumors that have stopped responding to standard therapies.
What could go wrong
This is a mid-stage trial with only 140 participants, so results may not apply to everyone. The virus injection can cause side effects like fever or tumor pain, and the treatment may not shrink tumors.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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California Cancer Associates for Research and Excellence, cCARE
San Marcos, California, 92069, United States
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City of Hope
Duarte, California, 91010, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Mary Crowley Cancer Research
Dallas, Texas, 75230, United States
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Providence Saint John's Health Center
Santa Monica, California, 90404, United States