ESOPHAGEAL CARCINOMA

This study is testing whether a new, step-by-step dosing guide called the PAGODA algorithm can help prevent unplanned delays in FOLFOX chemotherapy for people with gastrointestinal cancers. About 420 participants will be randomly assigned to have their chemotherapy doses adjusted…

This study is testing if adding a type of immunotherapy drug (called a PD-1 inhibitor) as ongoing 'maintenance' therapy helps people with locally advanced esophageal squamous cell cancer live longer without their cancer getting worse. It compares this new approach to the current …

This study is testing if adding an immunotherapy drug to a new, more targeted form of radiation and standard chemotherapy works better for treating advanced esophageal cancer. Researchers will compare the new three-part combination to just the targeted radiation and chemotherapy …

This study is testing whether giving a cancer immunotherapy treatment called nivolumab as an injection at home is a safe and practical alternative to receiving it at a clinic. It aims to see if home treatment reduces the burden of travel and improves quality of life for patients …

This study is testing two new blood tests designed to screen for 11 different cancers at the same time. It will enroll 24,000 healthy adults aged 45-75 to see how well these tests work for early detection and to understand how people and their doctors respond to the results. The …

This study is testing a new type of PET scan to see if it can tell doctors how well a patient's esophageal cancer is responding to chemotherapy and radiation. Researchers want to know if this scan can detect the cancer and show treatment effects earlier than current methods. The …

This study is testing if a heart medication called amiodarone can prevent a common and serious irregular heartbeat (atrial fibrillation) after a specific type of esophageal cancer surgery. About 90 patients will be randomly assigned to receive either the real medication or a plac…

This study is testing whether a pre-surgery program of exercise and nutrition supplements is practical and helpful for adults with esophageal cancer. Researchers want to see if this 'prehabilitation' improves patients' strength and well-being before and after their major surgery.…

This study is testing whether a yoga program for patients and their caregivers can improve physical function and quality of life during radiation treatment for lung or esophageal cancer. It will compare yoga sessions to educational sessions to see which helps patients walk farthe…

This study collects detailed information about side effects experienced by cancer patients receiving proton radiation therapy. Researchers will follow 5,000 patients to understand both short-term and long-term effects, aiming to predict risks and improve safety for future patient…

This early study aims to see how two new radioactive tracers travel through the body and gather in tumors. Researchers will give a single, tiny dose of one tracer to up to 32 patients with various solid tumors and then use PET/CT scans to track where it goes. The main goal is to …

This study is collecting tissue and blood samples from cancer patients over time to create a research resource called a biobank. Researchers will analyze these samples to understand how cancer changes during treatment and why some treatments stop working. The goal is to help scie…

This study is testing a special type of heart scan to see if radiation therapy for lung or esophageal cancer causes damage to the heart. Researchers will scan patients' hearts before, during, and after their cancer radiation treatment to look for changes. The goal is to learn if …