ESOPHAGEAL CARCINOMA

This phase 2 trial is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in 740 people with advanced solid tumors, including melanoma, lung, breast, and other cancers. The drug is given by IV every three weeks. The main goal is to see if the drug shrinks tumors.…

This early-stage study is testing an experimental drug called MK-6204 in about 90 adults with advanced solid tumors (such as colorectal, lung, or stomach cancer) that have not responded to standard therapies. The main goals are to check the drug's safety and find the right dose. …

This clinical trial is looking at the best timing for local treatments like surgery or radiation in people with esophageal or stomach cancer that has spread to only a few spots. All participants first get 4 months of standard drug therapy. Then, depending on their response, they …

This study tests whether adding immunotherapy (a drug that helps the immune system fight cancer) after standard chemotherapy and radiation can help people with advanced esophageal cancer live longer without the disease getting worse. About 452 adults with a specific type of esoph…

This early-stage trial is testing a new drug called INCB123667, taken as a tablet, in people with advanced solid tumors that have not responded to standard treatments. The study will first test the drug alone, then in combination with other cancer therapies. The main goals are to…

This study tests whether inflating a small balloon in the pylorus (the valve between stomach and small intestine) during minimally invasive esophageal cancer surgery can prevent delayed stomach emptying, a common complication. About 116 patients will be randomly assigned to recei…

This study tests a new drug called IMC-R117C, alone or with other cancer drugs, in people with advanced colorectal, esophageal, stomach, or ovarian cancers that have a specific genetic marker (HLA-A*02:01) and produce a protein called PIWIL1. The trial aims to find safe doses and…

This study tests whether adding immunotherapy to a precise type of radiotherapy (sparing tumor-draining lymph nodes) and chemotherapy can help adults with advanced esophageal cancer live longer without the disease getting worse. About 432 participants will receive either the comb…

This study is testing whether a new blood test can screen for many types of cancer at once. Researchers will enroll 24,000 adults aged 45-75 who do not have cancer. Participants will be randomly assigned to one of two blood test groups or a control group. The goal is to see how w…

This study is testing a simple, less invasive way to detect early signs of Barrett's esophagus, esophageal cancer, and stomach cancer. Participants swallow a capsule attached to a string, which expands into a sponge in the stomach to collect cell samples. Researchers then look fo…

This study tests whether giving the drug amiodarone after minimally invasive esophageal cancer surgery can prevent a common complication called atrial fibrillation (an irregular, often rapid heart rhythm). About 90 adults having this surgery will be randomly assigned to receive e…

This study compares giving the cancer drug nivolumab (Opdivo) as a shot at home versus in a clinic for people with various advanced cancers. The goal is to see if home treatment improves patients' overall care experience and quality of life. About 50 adults will receive the drug …

This study tests whether a program of exercise and nutrition supplements before esophageal cancer surgery is practical and helpful. About 20 adults scheduled for surgery will either receive the program or standard care. Researchers will track how many people stick with the progra…

This study tests whether a special algorithm called PAGODA can reduce unplanned delays during FOLFOX chemotherapy for gastrointestinal cancers like colon, stomach, and esophageal cancer. About 420 participants will be randomly assigned to either standard care or the algorithm-gui…

This study tests whether a yoga program designed for both patients and their family caregivers can improve physical function, fatigue, sleep, mood, and quality of life. It includes 400 people with lung or esophageal cancer who are getting radiation therapy, plus their caregivers.…

This study looked at whether low oxygen levels after esophageal cancer surgery increase the chance of a leak where the esophagus is reconnected. Researchers reviewed records of 2,083 patients, comparing those with low oxygen to those with normal levels. The goal was to see if cor…

This study is collecting information on side effects from proton therapy in 5,000 adults with many types of cancer. Researchers will track both short-term and long-term side effects and link them to the details of each patient's treatment plan. The goal is to better predict who m…

This study looks at people with a rare and aggressive type of esophageal cancer that hasn't spread. It compares those who had surgery (with or without other treatments) to those who had non-surgical treatments like chemotherapy and radiation. The goal is to see which approach hel…

This study looks at tissue samples from 30 adults with stomach or esophageal cancer that spread to the brain. Researchers compare the genetic markers of the original tumor and the brain tumor to see if they differ. The goal is to better understand how these cancers change when th…

This study collects tissue samples from people with various advanced or early-stage cancers to train a diagnostic platform called Elephas. The goal is to see how accurately it can predict whether a patient will respond to immunotherapy or chemoimmunotherapy. About 324 participant…

This study looks at whether PET/CT scans can detect heart damage caused by radiation therapy in people with lung or esophageal cancer. About 20 participants will get special heart scans before, during, and after their radiation treatment. The goal is to see if the scans can pick …

This early-phase trial is testing two new antibody fragments that are designed to attach to a sugar molecule found on many solid tumors. The fragments are labeled with a radioactive tracer so they can be seen on PET/CT scans. The study aims to see where these fragments go in the …

This study looks at whether changes in DNA markers in the blood can show how well esophageal cancer treatment is working. Researchers will compare these markers with standard CT/MRI scans and tumor markers. The goal is to find a simpler, less invasive way to track treatment respo…