ESOPHAGEAL CARCINOMA

This study tests whether giving a specific chemotherapy combination (mFOLFOX6) before the usual chemoradiation and surgery can help prevent esophageal cancer from coming back. About 40 adults with locally advanced esophageal cancer that can be surgically removed are participating…

This early-phase study tests a drug called veliparib combined with two standard chemotherapy drugs (carboplatin and paclitaxel) in people with advanced solid tumors who also have liver or kidney dysfunction. The main goals are to find the safest dose and understand how the body p…

This study looks at 60 people with advanced esophageal cancer who are getting chemotherapy or radiation before surgery to remove the cancer. Some patients had a feeding tube placed early, at the time of diagnosis, while others had it placed later during surgery. The goal is to se…

This study looks at whether a yoga program can help cancer patients and their partners improve physical function, quality of life, and reduce symptoms like fatigue and distress during radiation therapy. About 600 patients with lung, head and neck, or esophageal cancer, along with…

This study tests whether analyzing the genes of a patient's tumor can help doctors choose a more effective treatment. Over 6,400 adults with advanced solid tumors, lymphomas, or multiple myeloma that have not responded to standard therapy are enrolled. The goal is to see if targe…

This study looks at whether a new type of PET scan called 18F-FSPG PET/CT can help doctors see how well chemotherapy and radiation are working in people with esophageal cancer. Nine adults with untreated, locally advanced esophageal cancer will get the scan before and during trea…

This study collects tissue and blood samples, along with medical information, from 1,600 people with various advanced cancers. Researchers will store and study these samples over time to learn how cancer changes and why some treatments stop working. The goal is to improve future …