ESOPHAGEAL CARCINOMA

This study tests a tool called PAGODA that helps doctors adjust chemotherapy doses ahead of time to avoid unplanned treatment delays. About 420 people with cancers of the digestive system (like colon, stomach, or esophageal cancer) will take part. The goal is to see if using this…

This phase 3 trial tests whether adding immunotherapy (a PD-1 inhibitor) after standard chemoradiotherapy helps adults with locally advanced esophageal squamous cell cancer live longer without the disease getting worse. About 452 participants will be randomly assigned to receive …

This study looks at people with esophageal or stomach cancer that has spread to only a few places (oligometastases). All participants get 4 months of standard drug therapy, then are randomly assigned to either have local treatment (surgery or radiation) right away or after anothe…

This study tests whether adding immunotherapy to a precise type of radiation (sparing tumor-draining lymph nodes) plus chemotherapy can better control advanced esophageal cancer. About 432 adults with squamous cell carcinoma will receive either the triple combination or radiation…

This study tests whether the heart medication amiodarone can prevent atrial fibrillation (a fast, irregular heartbeat) in people recovering from minimally invasive esophageal cancer surgery. Atrial fibrillation is a common complication after this surgery, and there is no standard…

This study looks at whether giving the cancer drug nivolumab as a shot at home is as good as getting it at the clinic. About 50 adults with various cancers will try both ways to see which they prefer and how it affects their quality of life. The goal is to reduce the time, cost, …

This study tests whether a yoga program designed for both patients and their family caregivers can improve physical function, fatigue, sleep, and quality of life. It includes 400 people with lung or esophageal cancer who are getting radiation therapy, plus their caregivers. Parti…

This study looks at whether a program of exercise and nutrition supplements before esophageal cancer surgery is practical and helpful for patients. About 20 adults scheduled for surgery will either receive the program or standard care. Researchers will track how many people join,…

This study gathers information on short- and long-term side effects from proton therapy in adults with various cancers. Researchers will collect data from up to 5,000 participants to better understand and predict these side effects. The goal is to improve future treatment plannin…

This study uses special PET/CT scans to see how radiation therapy for lung or esophageal cancer affects the heart. About 20 adults getting radiation will have heart scans before, during, and after treatment. The goal is to learn if these scans can detect heart changes caused by r…

This study is testing whether a new radioactive imaging agent can safely and clearly show tumors in people with many types of solid cancers. About 32 adults will receive a single injection of the agent and then have PET/CT scans to see where it goes in the body. The goal is to le…

This study is testing new blood tests that look for signs of many different cancers at the same time. Researchers want to see if these tests can find cancer early, when treatment works best. About 24,000 adults aged 45 to 75 who do not have cancer will be split into three groups:…