Personalized chemo: could tumor DNA hold the key to better breast cancer treatment?
NCT ID NCT01180335
First seen Aug 17, 2026 · Last updated Aug 17, 2026
Summary
This trial is testing whether choosing chemotherapy based on the genetic profile of a patient's breast tumor can improve treatment response compared to standard chemotherapy. Women with HER2-negative breast cancer that is not eligible for conservative surgery will be randomly assigned to receive either standard chemo or a regimen selected based on specific gene activity in their tumor. The goal is to see if the genomic-driven approach leads to a higher rate of complete response before surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Genomic-driven chemotherapy (paclitaxel, FEC, docetaxel, capecitabine) chosen based on tumor gene activity
- What this could lead to
- If successful, this could show that tailoring chemotherapy to a patient's tumor genetics improves treatment response and outcomes for breast cancer.
- What could go wrong
- The trial is still in progress, and results are not yet known. The genetic approach may not prove better than standard chemo, and side effects from the drugs remain a risk.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Institut Gustave Roussy
Villejuif, 94800, France
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