Gustave Roussy, Cancer Campus, Grand Paris

This study tests whether adding a drug called ATRA (related to vitamin A) to targeted radiation therapy can prevent a drop in infection-fighting white blood cells (lymphocytes) in adults with solid tumors that have spread to a few spots. About 58 participants will receive radiati…

This study tests whether taking a special fecal transplant (MaaT033) alongside an immunotherapy drug (cemiplimab) can help overcome resistance caused by prior antibiotic use in people with advanced non-small cell lung cancer. About 162 participants will be randomly assigned to re…

This study tests a drug called tarlatamab in people with advanced small-cell lung cancer or other poorly differentiated neuroendocrine cancers. About 40 adults will receive the drug intravenously to see if it shrinks tumors and how long that effect lasts. Researchers will also co…

This study tests a new hormone therapy drug (elacestrant) given alone or with a drug that temporarily stops ovarian function in premenopausal women with early-stage, hormone-sensitive breast cancer. The goal is to see if the drug alone works as well as the combination at slowing …

This study tests a new drug called ASP3082 in people with advanced lung or pancreatic cancer that has a specific genetic change (KRAS G12D). About 60 participants will receive the drug intravenously once a week. The goal is to see if the drug shrinks tumors and to understand why …

This study is for people with a type of advanced lung cancer that has spread to only a few other places in the body (oligometastatic). The trial tests whether adding local treatments that destroy tumors (like radiation or ablation) to standard first-line immunotherapy can help pe…

This phase 3 trial tests whether the drug ONC201 works better than everolimus for children with diffuse intrinsic pontine glioma (DIPG), a rare and aggressive brain tumor. About 433 participants will be randomly assigned to one of the two drugs, and if their disease gets worse, t…

This study tests whether two common, low-cost drugs—aspirin and atorvastatin (a cholesterol-lowering statin)—can help men with advanced prostate cancer that no longer responds to hormone therapy live longer. About 1,210 men will be randomly assigned to take one or both drugs or a…

This study looks at how older adults (70+) with advanced kidney cancer handle a combination of two drugs, cabozantinib and nivolumab. Researchers want to see what doses work best and how often side effects cause treatment breaks. The goal is to improve treatment for this age grou…

This study tests a new drug called patritumab deruxtecan in people with advanced breast cancer that is hormone-receptor positive and no longer responds to hormone therapy or CDK4/6 inhibitors. About 99 participants will receive the drug every three weeks to see if it shrinks tumo…

This study tests whether taking a daily pill called olaparib for one year after standard treatment can help prevent endometrial cancer from coming back. It is for people with a specific type of aggressive endometrial cancer (p53abn). About 554 participants will be randomly assign…

This study tests whether adding a precise, high-dose X-ray treatment (contact X-ray brachytherapy) to standard chemotherapy can help people with intermediate-stage rectal cancer keep their rectum and avoid major surgery. About 212 adults with tumors 3.1 to 6 cm in size will be en…

This study tests a drug called valemetostat in people with advanced solid tumors that have certain gene changes (like SMARCB1 or ARID1A). The drug aims to reactivate protective genes to slow or stop cancer growth. About 900 adults will take the drug daily for up to 2 years, with …

This study tests a new vaccine designed to help the immune system fight HPV16, a virus linked to a type of throat cancer. The vaccine is given to patients who have already been treated for their cancer and show no signs of remaining disease. The goal is to find the safest dose th…

This study tests whether a near-infrared camera and a dye called indocyanine green can help surgeons spot tiny bits of cancer left behind during head and neck cancer surgery. About 65 adults with mouth or throat cancer will receive the dye before surgery, and the camera will scan…

This study tests whether a digital app (Open Food Facts) plus nutrition education can help 170 people at high risk for breast, pancreas, colon cancer, or with Lynch syndrome or BRCA mutations improve their diet quality. Participants will use the app to reduce ultra-processed food…

This study tests if shining a low-level laser inside the mouth before chemotherapy can prevent severe mouth sores in children and young adults aged 4 to 25. Participants receive either real laser treatment or a fake (placebo) treatment. The goal is to reduce painful sores that ca…

This study tests if a mobile app can improve quality of life for 180 women with early-stage breast cancer who are taking hormone therapy. Participants will either use the app plus standard care or standard care alone for 12 weeks. The goal is to see if the app helps reduce side e…

This study tests three different online programs to help people with cancer manage fatigue. 372 participants will either receive standard care or one of three digital aids: educational materials, a self-guided program, or a program guided by a psychologist. The goal is to see whi…

This study aims to analyze the DNA of tumors from 20,000 adults with cancer to identify genetic changes that can be targeted with existing or experimental drugs. By profiling each person's cancer, researchers hope to learn how many patients have a 'targetable' mutation and how of…

This study follows up to 1,150 children, teens, and young adults (up to age 25) with pediatric cancers that have come back or not responded to treatment, and who cannot join a clinical trial. Researchers collect information on how these patients get access to innovative medicines…

This study aims to create immune organoids—tiny, lab-grown models of the immune system—from the cells of children and young adults with brain tumors, kidney tumors, neuroblastoma, or sarcoma. Researchers will use these organoids to study how tumors interact with immune cells. The…

This study is for children whose cancer has come back or is not responding to standard treatments. Researchers use advanced genetic testing of the tumor to match each child with a specific targeted drug or drug combination. The main goals are to find the safest dose and see if th…

This study aims to better understand chronic myelomonocytic leukemia (CMML), a rare blood cancer. Researchers will collect blood and bone marrow samples from 5,000 adults with CMML, taken during routine care or other clinical trials. The goal is to improve diagnosis, predict how …

This study aims to find biological markers in tumor, blood, and other samples from 350 ovarian cancer patients. Researchers will track how these markers change with treatment and relate to outcomes like progression-free survival. The goal is to better understand why some cancers …

This study is testing whether tests on body fluids (like blood or urine) can find early-stage cancers in people at high risk. About 5,900 participants will be followed for 3 years to see if these tests can detect cancer before symptoms appear. The goal is to improve early detecti…

This study is for adults with any type of cancer. It looks at whether offering proactive supportive care—like help with emotional, practical, or physical needs—can reduce distress and unmet needs. Researchers will track 700 participants over 12 weeks using a simple distress therm…