Gustave Roussy, Cancer Campus, Grand Paris

This phase 3 trial is testing whether taking aspirin and atorvastatin (a common cholesterol-lowering drug) can help men with castrate-resistant prostate cancer live longer. The study plans to enroll 1210 participants who are starting their first treatment for this advanced stage.…

This phase 2 trial is testing valemetostat, a daily pill, in 900 adults with advanced solid tumors that have specific gene changes (like SMARCB1 or ARID1A). The drug works by blocking EZH1/2 enzymes to reactivate genes that normally protect against cancer. The main goal is to see…

This study tests whether taking a special fecal transplant (MaaT033) alongside an immunotherapy drug (Cemiplimab) can help overcome treatment resistance in advanced lung cancer patients who have taken antibiotics. Antibiotics can harm gut bacteria, which may make immunotherapy le…

This study tests a new drug called ASP3082 in 60 people with advanced lung or pancreatic cancer that has a specific gene change (KRAS G12D). Participants receive the drug intravenously once a week in 21-day cycles. The main goal is to see how well the drug shrinks tumors and to u…

This phase 3 trial tests whether the drug ONC201 works better than everolimus for children and adults with DIPG, a rare and aggressive brain tumor. About 433 participants will receive one of the two drugs, and can switch if their disease gets worse. The goal is to see which drug …

This study tests whether taking a daily targeted therapy pill (olaparib) for one year after standard chemoradiation can prevent endometrial cancer from coming back in patients with a specific genetic change (p53 abnormal). About 554 participants will be randomly assigned to recei…

This Phase 2 trial tests a drug called patritumab deruxtecan in people with advanced hormone-receptor-positive breast cancer that has stopped responding to hormone therapy and chemotherapy. The drug is designed to seek out and destroy cancer cells that have a protein called HER3 …

This phase 3 trial tests whether adding contact X-ray brachytherapy (a precise, high-dose radiation) to standard chemotherapy and radiation can help people with intermediate-stage rectal cancer keep their rectum instead of needing surgery to remove it. The study will enroll 212 a…

This study tests a vaccine designed to help the immune system fight HPV-positive throat cancer. It is for patients who have completed surgery or chemoradiation and show no signs of cancer remaining. The trial will enroll 24 adults to find the safest and most effective dose by mea…

This phase 2 trial is testing whether the drug elacestrant alone works as well as elacestrant combined with a drug that suppresses ovarian function (leuprorelin) in premenopausal women with early-stage, hormone-receptor-positive breast cancer. The study involves 140 women who wil…

This study tests whether adding a drug called ATRA (a form of vitamin A) to standard radiation therapy can prevent a drop in infection-fighting white blood cells in people with a few metastatic tumors. About 58 adults with solid cancers that have spread to up to 5 spots will rece…

This phase 2 trial is testing a drug called tarlatamab in 40 people with advanced small-cell lung cancer or other poorly differentiated neuroendocrine cancers. The drug is given by IV and aims to shrink tumors. Researchers will also study blood and tumor samples to understand why…

This study is looking at how older patients (70 years and older) with advanced kidney cancer handle a combination of two drugs: cabozantinib (a daily pill) and nivolumab (an IV infusion). The goal is to see how doctors actually use these drugs in real life, including starting dos…

This phase 3 trial tests whether adding local treatments like radiation or surgery to standard immunotherapy can help people with oligometastatic non-small cell lung cancer live longer. About 124 participants will be randomly assigned to receive either immunotherapy alone or immu…

This study is testing whether samples of blood, urine, or saliva can spot cancer early in people who are at high risk. About 5,900 participants will provide samples and be followed for three years to see if any develop cancer. The goal is to find a simple, non-invasive way to det…

This study tests whether a special dye (indocyanine green) and a near-infrared camera can help surgeons see tiny bits of cancer left behind during head and neck cancer surgery. About 65 adults with oral or throat cancer will receive the dye before surgery. The camera will scan th…

This study tests whether a smartphone app, combined with nutrition education, can help people at high risk for cancer eat healthier and reduce their cancer risk. About 170 participants will either get the app or standard advice, and researchers will measure changes in diet qualit…

This study tests whether low-level laser therapy can prevent severe mouth sores (mucositis) caused by chemotherapy in children and young adults aged 4 to 25. The laser is a painless, non-heating light applied to the mouth before chemotherapy. The trial is double-blind and placebo…

This study tests whether a mobile app called Resilience© can improve quality of life for early-stage breast cancer patients undergoing hormone therapy. The app provides education, symptom management tips, and personalized support. 180 participants in France will be randomly assig…

This study tests three digital support programs for cancer-related fatigue. 372 adults with cancer who have moderate to severe fatigue will use a mobile app with educational content, and some will also get a self-management program based on cognitive behavioural therapy, either s…

This study is testing whether growing a patient's tumor cells in the lab (as 3D 'organoids') can help doctors pick the best drug for advanced cancers that have stopped responding to standard treatments. About 152 adults with colorectal or pancreatic cancer will have a biopsy to c…

This study is collecting blood and bone marrow samples from 5,000 adults with chronic myelomonocytic leukemia (CMML) to better understand the disease. Researchers hope to improve diagnosis, predict how the disease will progress, and find new treatment options. Participants provid…

This study collects real-world data on how well new cancer drugs work in children, teens, and young adults up to age 25 who have relapsed or stopped responding to treatment and cannot join a clinical trial. Researchers will track safety and effectiveness of targeted therapies, im…

This study collects tumor, fluid, blood, and other samples from 350 ovarian cancer patients to find biological markers that predict how the disease will respond to treatment. Researchers will analyze genetic changes before and after therapy to understand why some cancers become r…

This study aims to create immune organoids—tiny lab-grown models of the immune system—using cells from children and young adults with brain tumors, kidney tumors, neuroblastoma, or sarcoma. Researchers will mix these organoids with tumor cells to see how they interact. The goal i…

This study will collect blood and tumor samples from 20,000 adults with solid tumors to perform detailed genetic analysis. The goal is to find how many patients have at least one genetic change that could be targeted by existing or experimental therapies. This is a research study…

This study is for children whose cancer has come back or not responded to standard treatments. Researchers will use advanced genetic testing of each child's tumor to match them with a targeted drug or drug combination. The goal is to find the safest dose and see if the treatment …

This study is testing a new way to provide supportive care for cancer patients. It will enroll 700 adults with any type of cancer. The care pathway includes a full needs assessment and referrals to support services. Researchers will measure whether this approach reduces patient d…