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New hope for kids with DIPG: major trial compares two treatments

NCT ID NCT05476939

Recruiting now Disease control Sponsor: Gustave Roussy, Cancer Campus, Grand Paris Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This phase 3 trial tests whether the drug ONC201 works better than everolimus for children and adults with DIPG, a rare and aggressive brain tumor. About 433 participants will receive one of the two drugs, and can switch if their disease gets worse. The goal is to see which drug delays tumor growth and extends life.

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Conditions

The condition(s) this trial relates to.

diffuse intrinsic pontine glioma diffuse midline glioma, H3 K27-altered diffuse midline glioma, H3 K27M-mutant

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIFFUSE INTRINSIC PONTINE GLIOMA DIFFUSE MIDLINE GLIOMA, H3 K27M-MUTANT DIFFUSE MIDLINE GLIOMA, H3K27-ALTERED

Contacts and locations

Locations

  • Aarhus Universitetshospital Skejby

    RECRUITING

    Aarhus, 8200, Denmark

  • CHRU Nancy - Hôpital central

    RECRUITING

    Nancy, 54035, France

  • CHRU Nancy Brabois - Hôpital d'enfants

    RECRUITING

    Nancy, 54500, France

  • CHRU Tours - Hôpital Bretonneau

    RECRUITING

    Tours, 37044, France

  • CHRU Tours - Hôpital Clocheville

    RECRUITING

    Tours, 37000, France

  • CHRU de Brest - Hôpital Morvan

    RECRUITING

    Brest, 29609, France

  • CHU Besançon - Hôpital Jean Minjoz

    RECRUITING

    Besançon, 25030, France

  • CHU Estaing

    RECRUITING

    Clermont-Ferrand, 63003, France

  • CHU François Mitterrand

    RECRUITING

    Dijon, 21079, France

  • CHU Grenoble Alpes - Hôpital Albert Michallon

    NOT_YET_RECRUITING

    Grenoble, 38700, France

  • CHU Grenoble Alpes - Hôpital Couple-Enfant

    RECRUITING

    Grenoble, 38700, France

  • CHU Poitiers

    RECRUITING

    Poitiers, 86021, France

  • CHU Rennes - Hôpital Sud

    RECRUITING

    Rennes, 35203, France

  • CHU Rouen Normandie - Hôpital Charles-Nicolle

    RECRUITING

    Rouen, 76000, France

  • CHU d'Amiens-Picardie Site Sud

    RECRUITING

    Amiens, 80054, France

  • CHU d'Angers - Bâtiment Robert Debré

    RECRUITING

    Angers, 49933, France

  • CHU de Bordeaux - Groupe hospitalier Pellegrin - Hôpital des enfants

    RECRUITING

    Bordeaux, 33076, France

  • CHU de Bordeaux - Groupe hospitalier Saint André - Hôpital Saint André

    RECRUITING

    Bordeaux, 33000, France

  • CHU de Caen - Hôpital Côte de Nacre

    RECRUITING

    Caen, 14033, France

  • CHU de Nice - Hôpital L'Archet 2

    RECRUITING

    Nice, 06202, France

  • CHU de Nice - Hôpital Pasteur 2

    RECRUITING

    Nice, 06000, France

  • CHU de Reims - American Memorial Hospital 2

    RECRUITING

    Reims, 51092, France

  • CHU de Saint-Denis de La Réunion

    RECRUITING

    Saint-Denis, 97400, France

  • CHU de Saint-Etienne - Hôpital Nord

    RECRUITING

    Saint-Etienne, 42270, France

  • CHU de Saint-Pierre de La Réunion Sud

    RECRUITING

    Saint-Pierre, 97488, France

  • Centre Eugène Marquis

    RECRUITING

    Rennes, 35042, France

  • Centre Jean Perrin

    RECRUITING

    Clermont-Ferrand, 63011, France

  • Centre Léon Bérard

    RECRUITING

    Lyon, 69373, France

  • Centre Oscar Lambret

    RECRUITING

    Lille, 59020, France

  • Centre Régional Lutte Contre le Cancer Paul STRAUSS

    RECRUITING

    Strasbourg, 67065, France

  • Gustave Roussy

    RECRUITING

    Villejuif, Val de Marne, 94805, France

  • H.C. Andersen Children's Hospital, Odense Universitetshospital

    RECRUITING

    Odense, 5000, Denmark

  • Helsinki University Hospital

    RECRUITING

    Helsinki, 00290, Finland

  • Hospital Universitario Niño Jesus

    RECRUITING

    Madrid, 28009, Spain

  • Hospital Universitario y Politécnico de La Fe

    RECRUITING

    Valencia, 46026, Spain

  • Hospital Vall D´Hebron

    RECRUITING

    Barcelona, 8035, Spain

  • Hôpital Arnaud de Villeneuve

    RECRUITING

    Montpellier, 34090, France

  • Hôpital Foch

    NOT_YET_RECRUITING

    Suresnes, 92150, France

  • Hôpital Pierre Wertheimer

    RECRUITING

    Lyon, 69500, France

  • Hôpital Roger Salengro

    NOT_YET_RECRUITING

    Lille, 59037, France

  • Hôpital Saint Louis

    RECRUITING

    Paris, 75010, France

  • Hôpital de Hautepierre

    RECRUITING

    Strasbourg, 67200, France

  • Hôpital de La Timone

    RECRUITING

    Marseille, 13005, France

  • Hôpital de la mère et de l'enfant

    RECRUITING

    Limoges, 87042, France

  • Hôpital des enfants

    RECRUITING

    Toulouse, 31059, France

  • Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix

    RECRUITING

    Paris, 75013, France

  • Institut Curie

    RECRUITING

    Paris, 75248, France

  • Institut Universitaire du Cancer de Toulouse-Oncopole (IUCT-O) - Institut Claudius Regaud

    RECRUITING

    Toulouse, 31059, France

  • Institut de Cancérologie de l'Ouest (ICO) - Site Paul Papin

    RECRUITING

    Angers, 49055, France

  • Karolinska University Hospital

    RECRUITING

    Stockholm, 17176, Sweden

  • Oslo University Hospital, Radiumhospitalet

    RECRUITING

    Oslo, 0379, Norway

  • Oslo University Hospital, Rikshospitalet

    RECRUITING

    Oslo, 0372, Norway

  • Rigshospitalet

    RECRUITING

    Copenhagen, 2100, Denmark

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