Engineered immune cells target deadly brain tumors in children
NCT ID NCT07680439
First seen Jul 02, 2026 · Last updated Aug 05, 2026 · Updated 2 times
Summary
This study tests a new treatment called BCB-276 for children and young adults with diffuse intrinsic pontine glioma (DIPG), a rare and aggressive brain tumor. BCB-276 is made from a patient's own immune cells, which are modified in a lab to recognize and attack the cancer. The treatment is given directly into the fluid around the brain every two weeks for about 7-8 months. The goal is to see if it is safe and can help people live longer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- BCB-276 (a CAR T cell therapy made from the patient's own immune cells, targeting B7-H3)
- What this could lead to
- If successful, this could offer a new treatment option for DIPG, a rare and aggressive brain tumor with few effective therapies, potentially improving survival.
- What could go wrong
- This is an early-phase trial with a small number of participants. The therapy may cause serious side effects, and it is not yet known if it will improve survival compared to standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Children's Healthcare of Atlanta
NOT_YET_RECRUITINGAtlanta, Georgia, 30329, United States
Contact Email: •••••@•••••
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Children's Hospital Los Angeles
NOT_YET_RECRUITINGLos Angeles, California, 90027, United States
Contact Email: •••••@•••••
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Children's Hospital of Philadelphia
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Lurie Children's Hospital
NOT_YET_RECRUITINGChicago, Illinois, 60611, United States
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Nationwide Children's Hospital
NOT_YET_RECRUITINGColumbus, Ohio, 43205, United States
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Seattle Children's Hospital
RECRUITINGSeattle, Washington, 98105, United States
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