PEDIATRIC CANCER

This study tests a combination of three drugs (pucotenlimab, lenvatinib, and irinotecan) in children aged 2-18 with advanced hepatoblastoma that has not responded to prior treatment. The goal is to see if this combo can control the cancer longer. Participants will receive the tre…

This study tests a combination of four drugs (cyclophosphamide, sorafenib, bevacizumab, and atezolizumab) in children and young adults with solid tumors that have come back or not responded to treatment. The goal is to find safe doses and see if the drugs shrink tumors. The trial…

This study tests a laser treatment called LITT for children, teens, and young adults whose low-grade brain tumors have come back or worsened after prior therapy. The goal is to stop tumor growth for at least 15 months. About 40 participants will receive the laser procedure, which…

This study tests whether giving targeted drugs before radioactive iodine (RAI) can make thyroid cancer cells absorb more RAI, potentially improving treatment. It includes 32 children and young adults with advanced thyroid cancer that has spread to the lungs. The goal is to see if…

This study is testing a drug called lurbinectedin in people aged 10 and older whose solid tumors (like Ewing sarcoma) have come back or not responded to standard treatment. The goal is to see if the drug is safe and can shrink tumors or delay their growth. Participants must have …

This study tests whether giving a drug called selpercatinib for 6 months before radioactive iodine therapy can improve treatment outcomes in children, teens, and young adults (ages 2-25) with a specific genetic form of thyroid cancer (RET fusion). The goal is to make the cancer a…

This early-phase study tests a new drug called CBA-1205, an antibody that targets a protein (DLK1) found on some cancer cells. The main goal is to check safety and find the right dose in about 66 adults with advanced solid tumors, including liver cancer and melanoma. Participants…

This study is testing whether a drug called larotrectinib can make radioactive iodine therapy more effective for people with advanced thyroid cancer that has spread to the lungs. The goal is to see if taking larotrectinib before standard radioactive iodine treatment helps shrink …

This study looks at whether wearing virtual reality glasses before a spinal chemotherapy procedure can lower anxiety, fear, and improve vital signs like heart rate in children aged 4 to 10 with cancer. Researchers will compare a group that uses the goggles to a group that does no…

This study looks at whether massage therapy can improve sleep for children and teens (ages 12-21) who are in the hospital for cancer treatment or a stem cell transplant. Researchers will compare sleep minutes and quality between those who get standard care and those who also rece…

This study tests whether a smartphone app that guides users through art therapy can help young adults (ages 18-25) who survived childhood cancer feel better emotionally. Participants use the app for 6 weeks, completing weekly art prompts and surveys about their mood and quality o…

This study looks at whether providing free, healthy frozen meals to families of children undergoing cancer treatment is practical and helpful. About 30 children aged 12-17 and their parents will take part. The goal is to see if families find the meal program easy to use and suppo…

This study explores whether a normal camping experience can improve the psychological well-being of children aged 7-17 with cancer, as well as young adult survivors who serve as counselors. Participants attend a 7-day camp with age-appropriate activities and medical support. Rese…

This study tests if a telehealth program called I-PCIT can help parents manage disruptive behavior in children aged 2-12 who have or had cancer treatment. About 300 families will either get the therapy right away or wait 5-6 months. The goal is to see if the program is practical …

This study tests whether a structured exercise routine (30 minutes, five days a week) helps children and young adults aged 2–25 with newly diagnosed cancer maintain physical function and emotional well-being during chemotherapy. Participants are randomly assigned to either an exe…

This study looks at whether a Snoezelen multisensory relaxation room can reduce anxiety in children and teens (ages 8-17) who are hospitalized for chemotherapy. Twenty participants will compare their feelings during a chemo cycle without Snoezelen to a later cycle where they have…

This study tests a therapy called EASE for parents of children recently diagnosed with cancer. The goal is to see if it reduces traumatic stress symptoms compared to usual care alone. About 306 parents will take part, answering questionnaires over six months.

This study tests whether guided imagery—a relaxation technique using mental images—can reduce nausea and vomiting caused by chemotherapy in children with cancer. About 40 children aged 7 to 18 will either receive guided imagery plus standard care or standard care alone. Researche…

This study tests whether a computer model (machine learning) can help prevent vomiting in children being treated for cancer. About 1,332 children admitted to the hospital will have their risk of vomiting in the next 96 hours predicted daily. Pharmacists will then alert the medica…

This study tests a special film that dissolves in the mouth to prevent vomiting caused by radiation therapy in children aged 1 to 14 with cancer. The film contains ondansetron, a medicine that blocks nausea signals. Researchers will compare how well it works and check for side ef…

This study looks at children who received radiation therapy for cancer to understand their risk of developing thyroid nodules or thyroid cancer later in life. Researchers will track 2,550 participants to find out how common these thyroid problems are and what factors increase the…

This study is for children whose cancer has come back or is not responding to standard treatments. Researchers use advanced genetic testing of the tumor to match each child with a specific targeted drug or drug combination. The main goals are to find the safest dose and see if th…

This study follows up to 1,150 children, teens, and young adults (up to age 25) with pediatric cancers that have come back or not responded to treatment, and who cannot join a clinical trial. Researchers collect information on how these patients get access to innovative medicines…

This study follows children under 21 who have a genetic condition that raises their risk of cancer, along with their relatives. Researchers collect health data and samples to better understand how these cancers develop and how to catch them early. The goal is to improve monitorin…

This study watches how children and their caregivers recover after major cancer surgery. About 40 kids and their parents will wear smartwatches, answer surveys, and give extra blood samples for up to a year. The goal is to find patterns that show how well someone is bouncing back…

This study creates a registry of 500 children, teens, and young adults (up to age 39) diagnosed with cancer. Participants fill out surveys, do physical and thinking tests, and give blood or other samples at diagnosis, during treatment, and yearly after. The goal is to learn how c…

This study is testing a new tool called the Cancer Care Companion, which is built into the electronic health record system. The goal is to see if it helps parents of children with cancer better communicate with doctors and manage their child's care at home. About 40 parents will …

This study is creating a large database of tumor samples and health information from children and young adults with cancer. Researchers will analyze the genetic makeup of these tumors to find patterns and potential new treatment targets. The goal is to better understand pediatric…

This study tests whether a special video and a helper (navigator) can improve how parents and doctors talk about treatment goals for children with cancer. About 567 parents of children aged 0-12 with any type of cancer will take part. The goal is to see if this tool leads to bett…

This study looks at how well the immune system works in children who have finished cancer treatment. It also tests restarting routine vaccines just 3 months after therapy ends, which is earlier than usual. Researchers will compare giving a single booster shot versus a full series…

This study tests whether trained peer navigators can help Hispanic families enroll their children with cancer in clinical trials. About 450 parents of Hispanic children (ages 0-17) with newly diagnosed cancer will be randomly assigned to receive either peer navigation or standard…

This study looks at whether families of children with cancer are willing to join a program that provides extra money (called PediRISE) to help with financial stress. About 40 families will be randomly assigned to either receive the support or continue with usual care. The main go…

This study observes 500 Indian children with acute lymphoblastic leukemia to see how their genes influence treatment side effects and response to steroids. Researchers will track toxicities and treatment outcomes over five years. No new drug is tested; the goal is to better under…

This study explores how parents of children with blood cancers cope with stress and how their coping style affects their child. Researchers will survey 60 parents and their children (ages 8-17) at multiple hospitals in Italy. The goal is to learn which coping strategies work best…

This study is testing a questionnaire called QUOCCAS that parents and children fill out to see if it can accurately identify kids with cancer who might have an inherited cancer risk. About 205 children and teens with cancer will take part, and some families will also receive an e…

This study works with Spanish-speaking parents, interpreters, and doctors to create educational videos about childhood cancer. The goal is to see if these videos help caregivers better understand their child's care and feel more supported. Ten families will help test the videos, …

This study watches how children and young adults with cancer improve their ability to move and do daily tasks while receiving physical therapy. Researchers will track 249 patients across Italy to see what helps them get better. The goal is to learn which rehab methods work best, …

This study is testing whether a group of specialists from different hospitals can come up with new treatment ideas for children and young adults with cancer that is very hard to cure. The team will review each patient's case and suggest a different treatment plan than what their …

This study is creating a large database of children with cancer in French African oncology units. By collecting information on cancer type, stage, treatment, and outcomes, the registry aims to help health authorities plan better care. Up to 10,000 children under 18 with any cance…

This study is for children with blood cancer who are getting the seasonal flu vaccine. Researchers want to see how their immune system responds to the vaccine and how long that protection lasts. Up to 150 children will take part at St. Jude Children's Research Hospital. The goal …