PEDIATRIC CANCER

This early-stage study tests a new drug called CBA-1205 in people with advanced solid tumors (like liver cancer or melanoma) that have not responded to other treatments. The main goal is to check the drug's safety and find the best dose. About 66 participants will receive the dru…

This study is testing a combination of four drugs—atezolizumab, sorafenib, bevacizumab, and cyclophosphamide—in children and young adults with solid tumors that have come back or not responded to standard treatment. The goal is to find safe doses and see if the combination can sh…

This study tests whether giving the targeted drug selpercatinib for 6 months before standard radioactive iodine therapy can improve outcomes for children, adolescents, and young adults (ages 2-25) with a specific type of thyroid cancer linked to RET gene fusions. The goal is to s…

This study tests a laser treatment called LITT for children, teens, and young adults whose low-grade brain tumors have come back or grown after prior therapy. About 40 participants will receive the laser procedure to heat and destroy tumor tissue. The main goal is to see how many…

This study tests a drug called lurbinectedin in people aged 10 and older whose solid tumors (like Ewing sarcoma) have returned after standard treatment. The goal is to see if the drug is safe and can shrink tumors or delay their growth. Participants must have a specific genetic c…

This study tests whether giving targeted drugs before radioactive iodine (RAI) can make thyroid cancer tumors absorb more RAI, potentially improving treatment. It includes 32 children and teens with metastatic differentiated thyroid cancer that has spread to the lungs. Researcher…

This phase 2 trial tests whether giving larotrectinib for 6 months can make thyroid cancer cells more responsive to radioactive iodine therapy. It enrolls 13 children and young adults with a specific genetic change (NTRK fusion) whose cancer has spread to the lungs. The goal is t…

This study is testing a combination of three drugs—pucotenlimab (an immunotherapy), lenvatinib (a targeted therapy), and irinotecan (chemotherapy)—in children aged 2-18 with advanced or relapsed/refractory hepatoblastoma, a rare liver cancer. The goal is to see if this combinatio…

This study tests a simple questionnaire to help doctors identify sexual health concerns in teenagers and young adults who have or had childhood cancer. The goal is to improve communication between patients and providers. About 205 participants aged 15-24 will use the screening to…

This study explores whether a normal week-long camping experience can improve the psychological well-being of children with cancer. Researchers will interview children and families before, during, and after camp to measure changes in self-esteem and social interactions. Up to 5,0…

This study tests an online program called eSCCIP designed to help parents and caregivers of children with cancer feel less distressed and more able to cope. The program includes web-based modules and video sessions with a coach. Researchers will compare it to a basic informationa…

This study tests whether using virtual reality before proton therapy sessions can reduce stress and improve positioning in children aged 7 to 18 with cancer. Researchers will compare positioning time and anxiety levels when kids use VR versus standard care. The goal is to find a …

This study tests whether a video and a trained navigator can help parents of children with cancer better communicate their goals and values to the medical team. About 567 parents will either get the video tool or usual care. The goal is to see if this leads to more discussions ab…

This study tests whether guided imagery—a relaxation technique using calming mental pictures—can reduce nausea and vomiting caused by chemotherapy in children aged 7 to 18 with cancer. Half of the 40 participants will receive guided imagery plus standard care, while the other hal…

This study tests whether an internet-based parent-child interaction therapy (I-PCIT) can help improve behavior in children aged 2-12 who have or had cancer. Parents of 300 children will be randomly assigned to start therapy right away or wait 5-6 months. The goal is to see if the…

This study looks at whether wearing virtual reality glasses before a spinal chemotherapy procedure can lower anxiety, fear, and improve heart rate and breathing in children aged 4 to 10 with cancer. Twenty children will be split into two groups: one group uses the VR glasses, and…

This study tests whether regular massage therapy can improve sleep for children aged 12-21 who are hospitalized for cancer treatment or stem cell transplant. Seventy participants will either receive standard care or a 20-30 minute massage five days a week for three weeks. Sleep w…

This study tests whether Snoezelen, a multisensory relaxation approach using lights, sounds, and textures, can reduce anxiety in children aged 8 to 17 who are hospitalized for chemotherapy. Twenty participants will compare their symptoms during a chemo cycle with Snoezelen sessio…

This study tests whether a computer model can predict vomiting in children with cancer who are in the hospital. The model uses each child's medical information to estimate their risk of vomiting in the next 96 hours. Doctors and pharmacists will use this information to give extra…

This study is testing a new tool called the Cancer Care Companion, which is accessed through a patient portal. Parents of children recently diagnosed with cancer will use it for 3 months to complete educational tasks, surveys, and read patient stories. The goal is to see if the t…

This study tests a program called TIPPI-R that teaches children with cancer and their families ways to manage pain and distress during treatment. About 100 children aged 0-18 will either receive the program or standard care. Researchers will compare how well they cope with pain a…

This study is testing whether a structured exercise program called 'Just Move' can help children and young adults (ages 2–25) with newly diagnosed cancer maintain physical function and improve quality of life during chemotherapy. Participants will either follow a 30-minute exerci…

This study looks at whether providing free, healthy frozen meals to families of children with cancer is practical and helpful. About 30 children aged 12-17 and their parents will receive meals for 12 weeks during chemotherapy. The goal is to see if families find the meals easy to…

This study tests a talk therapy called EASE for parents whose child has cancer. The goal is to see if it reduces traumatic stress symptoms over six months. About 306 parents will take part, answering questionnaires at several points. The therapy is added to usual care and compare…

This study tests a dissolvable film containing ondansetron to prevent vomiting caused by radiation therapy in children aged 1-14 with cancer. The film is placed on the tongue and melts without water. Researchers will compare its effectiveness and safety against standard care in 6…

This study tests whether a digital art therapy app called ARTCan is practical and acceptable for young adults aged 18-25 who survived childhood cancer. Participants use the app for 6 weeks to create art and complete mood surveys. The goal is to see if at least 10 out of 15 partic…

This study tests a mobile app designed to help children aged 9 to 16 who have recently finished cancer treatment manage their symptoms. The app provides educational materials and real-time support, plus personalized help from a nurse. Researchers want to see if using the app for …

This study aims to understand how well the seasonal flu vaccine works in children with blood cancers like leukemia. Researchers will measure the immune response in up to 150 children at St. Jude Children's Research Hospital. The goal is to see if the vaccine triggers enough prote…

This study will follow 6,000 children, adolescents, and young adults with cancer in low- and middle-income countries. Researchers will collect data from medical records and questionnaires to understand why treatment failure and severe side effects are more common in these setting…

This study is creating a large research database of childhood cancer survivors treated at Children's Hospital Los Angeles. The goal is to track their long-term health, identify late effects from cancer therapy, and find ways to improve their quality of life. Up to 5,000 survivors…

This study tests whether a program called COMPRENDO, which uses trained peer navigators, can help more Hispanic children with cancer enroll in clinical trials. The navigators provide education and support to parents in English or Spanish. The study will compare enrollment rates a…

This study asks families of children with cancer to donate their child's tumor tissue after death. Researchers will use the tissue to create lab models and share samples with other scientists. The goal is to better understand pediatric cancers and develop new treatments. Up to 15…

This study is building a registry of 500 children, teens, and young adults (ages 1-39) diagnosed with cancer. Participants will complete physical and mental function tests, surveys, and provide blood samples over time. The goal is to learn how cancer and its treatments affect agi…

This study tests a questionnaire called QUOCCAS that parents and children fill out to see if it can spot kids with a higher chance of having an inherited cancer syndrome. About 205 children and teens with cancer will take part, giving a blood or saliva sample for genetic testing.…

This study looks at how parents of children with cancer cope with stress and how that affects their child's emotional well-being. Researchers will survey 60 parents and their children (ages 8–17) being treated at pediatric cancer centers in Italy. The goal is to understand which …

This study collects real-world data on how well new cancer drugs work in children, teens, and young adults up to age 25 who have relapsed or stopped responding to treatment and cannot join a clinical trial. Researchers will track safety and effectiveness of targeted therapies, im…

This study follows 249 children and young adults with cancer who are receiving physical or neuropsychomotor therapy at hospitals across Italy. Researchers will measure changes in their ability to move and perform daily tasks over time. The goal is to understand which rehabilitati…

This study follows children who had radiation therapy for cancer to see how often they develop thyroid nodules or thyroid cancer. Researchers will compare them to children who did not have radiation, looking for risk factors and genetic clues. The goal is to create better screeni…

This study works with Spanish-speaking parents and doctors to create educational videos about childhood cancer. The goal is to help caregivers better understand their child's care when English is not their first language. The project will test if these videos are easy to use and …

This study is testing whether a special team of experts, including biologists, mathematicians, and doctors, can come up with new treatment ideas for children and young adults with cancer that is unlikely to be cured by standard treatments. The team will review each patient's case…

This study looks at whether families of children with cancer are willing to join a program that provides financial support. About 40 families will be randomly assigned to either receive the PediRISE support program or standard care. The goal is to see if the program is feasible a…

This study is creating a large database of tumor samples and health information from children and young adults with cancer. Researchers will analyze the genetic makeup of these tumors to find patterns and potential new treatments. The goal is to better understand pediatric cancer…

This study is testing whether smartwatches and blood tests can measure how well children recover after surgery to remove a solid tumor. About 40 children and their caregivers will wear smartwatches and answer questionnaires before surgery and for up to a year after. Researchers w…

This study looks at how well the immune system works in children who have finished cancer treatment. It aims to see if restarting vaccinations just 3 months after therapy is safe and effective. Researchers will compare giving a single booster shot versus a full series of vaccines…

This study is for children whose cancer has come back or not responded to standard treatments. Researchers will use advanced genetic testing of each child's tumor to match them with a targeted drug or drug combination. The goal is to find the safest dose and see if the treatment …

This study is observing 500 Indian children with acute lymphoblastic leukemia (ALL) to see how their genes influence treatment side effects and how well they respond to therapy. Researchers will track side effects and measure early response to steroids. The goal is to better unde…

This study follows children under 21 who have a genetic condition that raises their risk of developing cancer, along with their relatives. Researchers will collect health information and samples over time to better understand how these cancers develop and how to catch them early.…

This study is creating a registry to collect information about children under 18 who are treated for cancer at participating hospitals in Africa. The goal is to track how many children have cancer, what types and stages they have, what treatments they receive, and how they do ove…