New cocktail of four drugs aims to tackle childhood cancers that Won't go away
NCT ID NCT05468359
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing a combination of four drugs—atezolizumab, sorafenib, bevacizumab, and cyclophosphamide—in children and young adults with solid tumors that have come back or not responded to standard treatment. The goal is to find safe doses and see if the combination can shrink tumors. The trial has two parts: the first focuses on safety and dosing, and the second looks at how well the treatment works in specific rare cancers like fibrolamellar carcinoma and hepatocellular carcinoma.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Atezolizumab, sorafenib, bevacizumab, and cyclophosphamide
- What this could lead to
- If successful, this could offer a new treatment option for children with relapsed or hard-to-treat solid tumors, including rare liver cancers.
- What could go wrong
- This is an early-phase trial with a small number of participants. The drug combination may cause serious side effects, and it is not yet known if it will shrink tumors or improve survival.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Methodist Le Bonheur Healthcare
WITHDRAWNGermantown, Tennessee, 38138, United States
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St. Jude Children's Research Hospital
RECRUITINGMemphis, Tennessee, 38105, United States
Contact Email: •••••@•••••
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