New combo aims to supercharge standard thyroid cancer therapy
NCT ID NCT05783323
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether giving larotrectinib for 6 months can make thyroid cancer cells more responsive to radioactive iodine therapy. It enrolls 13 children and young adults with a specific genetic change (NTRK fusion) whose cancer has spread to the lungs. The goal is to see if more patients achieve complete shrinkage of lung tumors compared to standard treatment alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Larotrectinib (a targeted cancer drug) and radioactive iodine (131I)
- What this could lead to
- If it works, this could make radioactive iodine therapy more effective for people with a specific type of thyroid cancer, potentially reducing the need for stronger treatments.
- What could go wrong
- This is a small, early-phase trial with only 13 participants, so results may not apply to everyone. Larotrectinib and radioactive iodine can have side effects, and the combination may not improve outcomes as hoped.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Seattle Children's Hospital
RECRUITINGSeattle, Washington, 98105, United States
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St. Jude Children's Research Hospital
RECRUITINGMemphis, Tennessee, 19807, United States
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University of California, San Francisco
RECRUITINGSan Francisco, California, 94115, United States
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