Can off-label cancer drugs help children? a national study aims to find out

NCT ID NCT07727694

Recruiting now Knowledge-focused Sponsor: Universitaire Ziekenhuizen KU Leuven Source: ClinicalTrials.gov ↗

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This study collects safety and effectiveness data on cancer medicines used off-label or through compassionate access in children, adolescents, and young adults up to age 25 with pediatric malignancies. Participants are not enrolled in other treatment trials and are discussed by expert tumor boards. The goal is to gather real-world evidence on how these innovative drugs work in younger patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: off-label or compassionate-use cancer medicines (targeted therapies, immunotherapies, chemotherapies) approved in adults after 2007
What this could lead to: If successful, this could provide real-world evidence to support safer and more effective use of innovative cancer drugs in children and young adults.
What could go wrong: This is an observational data collection study, not a controlled trial, so it cannot prove cause and effect. Results may be limited by incomplete data or differences in how patients are treated.

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Conditions

The condition(s) this trial relates to.

childhood malignant neoplasm neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PEDIATRIC CANCER

Contacts and locations

Locations

CHC Montlégia
NOT_YET_RECRUITING

Liège, 4000, Belgium
Cliniques Universitaires Saint-Luc
NOT_YET_RECRUITING

Brussels, 1200, Belgium
Hôpital Universitaire des Enfants Reine Fabiola (HUDERF)
NOT_YET_RECRUITING

Brussels, 1020, Belgium
University Hospital Antwerp
NOT_YET_RECRUITING

Antwerp, 2650, Belgium
University Hospital Gent
NOT_YET_RECRUITING

Ghent, 9000, Belgium
University Hospital Leuven
RECRUITING

Leuven, 3000, Belgium

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