Universitaire Ziekenhuizen Ku Leuven

This study is testing whether changing the body's metabolism through a ketogenic diet or ketone supplements can improve the function of the lymphatic system and reduce swelling in people with arm lymphedema. Researchers will compare a strict ketogenic diet, a standard diet with k…

This study is testing whether adjusting the settings of an existing pacemaker can help people with a specific type of heart failure (HFpEF) feel better during daily activities. Researchers will measure heart pressure in 20 patients while they do light cycling, seeing if increasin…

This early study is testing whether two doses of an immunotherapy drug called dostarlimab can help shrink colon tumors before surgery. Researchers will give the drug to 10 patients with stage III colon cancer and study how their tumors and blood change in response. The main goal …

This study is testing a new, smaller wireless pacemaker called Micra AV2 in people with a serious type of heart block. The goal is to see how well it keeps the upper and lower chambers of the heart beating in sync during daily life and exercise. Researchers will also check its sa…

This study is testing whether combining two existing drugs, bicalutamide and abemaciclib, can help control a hard-to-treat form of advanced breast cancer. It is for women whose cancer has a specific marker (androgen receptor positive) and has worsened after at least one prior tre…

This study is testing if adding a special low-calorie 'fasting-mimicking' diet and an exercise program to standard chemotherapy and immunotherapy can make the cancer treatment more effective for people with triple-negative breast cancer. It will involve 356 participants who will …

This study is testing whether adding a new targeted drug called Zolbetuximab to standard chemotherapy improves survival for people with advanced stomach or esophageal cancer. It's for patients whose cancer has a specific protein marker called CLDN18.2 and whose disease has progre…

This study is testing whether a single, low-dose radiation treatment to the whole heart can help people with advanced heart failure. Researchers want to see if this approach can improve heart function by at least 5% over six months in 40 participants who haven't responded well to…

This study compares two tiny, minimally invasive eye implants for adults with open-angle glaucoma that isn't controlled with eye drops alone. Researchers will randomly assign 166 participants to receive either the XEN-63 Gel Stent or the PRESERFLO MicroShunt during a single surge…

This study follows children with cow's milk allergy who didn't become tolerant after previous treatment. Researchers will observe them for up to 4 years to see if they naturally develop the ability to drink milk without reactions. The study tracks any reactions and aims to unders…

This study is testing different biological materials to see which works best for helping bone regrow around teeth during gum surgery. It involves 30 adults with advanced gum disease who have a specific type of bone defect. During a minor surgical procedure, one of four material c…

This study is testing if using a CPAP breathing machine during radiation therapy can lower the amount of radiation that reaches the heart and lungs of breast cancer patients. The goal is to reduce the risk of long-term heart and lung problems that can be caused by radiation treat…

This study is testing a new, standardized recovery plan for older adults who need surgery for a chronic subdural hematoma, a type of brain bleed. The plan includes guidance on treatment decisions, surgical techniques, and post-surgery care. Researchers will compare the new plan t…

This study aims to make a personalized form of radiotherapy for advanced lung cancer faster and more comfortable to deliver. It will test whether using artificial intelligence (AI) tools and a different type of scan can speed up the process of adjusting a patient's radiation plan…

This study is testing if wearing a heart rhythm monitor for 14 days is better than the standard 24-hour test at finding dangerous irregular heartbeats in people with mitral valve prolapse (MVP). Researchers will enroll 60 adults with MVP to see how much the heart rhythm varies da…

This study is testing whether ultrasound scans can be used to better track the progression of Dupuytren's disease, a hand condition that causes fingers to curl inward. Researchers will enroll 20 patients with early-stage disease to see if specific ultrasound measurements can pred…

This study is testing a digital tool designed to safely check and correct antibiotic allergy labels in patient records. Many people have incorrect labels that limit their antibiotic options, leading to longer hospital stays and less effective treatments. The tool uses a questionn…

This study is testing a lifestyle program to see if it can help twin pregnancies last longer and reduce the risk of early birth. It will enroll 81 women with twin pregnancies before their 14th week. The program combines nutrition advice, physical activity, and mindfulness practic…

This study compares two types of minimally invasive surgery for people with inflammatory bowel disease (IBD) who need colon surgery. Researchers will randomly assign 110 patients to either robotic-assisted surgery or standard laparoscopic surgery to see which approach leads to fe…

This study is testing whether adding tongue scraping to standard oral hygiene instructions helps reduce bad breath in people with gum disease. Researchers will compare the standard gum cleaning treatment with and without the use of a tongue scraper. The goal is to see if this sim…

This study aims to understand how patients recover physically and mentally after limb-saving surgery for bone or soft tissue sarcoma in the leg. Researchers will observe 60 adult survivors, focusing on their walking patterns, physical function, and overall quality of life. The go…

This study aims to understand why some people with severe flu pneumonia in the ICU later develop a dangerous fungal lung infection called aspergillosis. Researchers will compare the immune systems of 45 ICU patients with severe flu pneumonia to those with other severe pneumonias.…

This study aims to better understand the chronic pain experienced by most people with ADPKD, a genetic kidney disease. Researchers will compare pain sensitivity and quality of life in 150 patients with ADPKD against healthy volunteers using standardized tests and questionnaires. …

This study aims to understand how skin involvement affects outcomes after surgery for Dupuytren's disease, a hand condition causing finger contractures. Researchers will use ultrasound and skin elasticity tests on 50 patients undergoing standard surgery to see if these measuremen…

This study aims to better understand how adults with spinal deformities maintain their balance while standing and walking. Researchers will observe 265 participants, some with spinal conditions and some without, using motion capture cameras, muscle activity sensors, and balance t…

This study aims to understand why some people get very sick from COVID-19 while others have milder illness. Researchers will collect blood and other samples from 100 hospitalized adult patients with confirmed COVID-19. By comparing patients with severe and non-severe disease, the…

This study aims to understand how the stomach and intestines work after weight loss surgery. Researchers will enroll 51 adults who have had surgery or are living with obesity. Participants will have two visits: one to collect fluid samples from their gut and another to swallow a …

This study aims to learn more about smell and taste disorders, which are common and can significantly affect quality of life. Researchers will follow 500 people in Belgium who have these conditions. They will use standard tests and questionnaires to track how severe the problems …

This study aims to understand why the socket part of a shoulder replacement sometimes becomes loose over time. Researchers will use special, low-dose X-ray imaging to watch how the shoulder bones move and make contact in 52 people with severe shoulder arthritis, both before and a…

This study aims to improve how surgeons plan operations for adolescent idiopathic scoliosis, a curvature of the spine. Researchers will collect detailed movement and imaging data from 100 patients aged 10-35 who are scheduled for surgery. The goal is to identify key 3D measuremen…

This study is testing a new type of brain scan to measure levels of a specific protein called Hsp90. Researchers will compare scans from healthy volunteers to those from people with Alzheimer's disease, Parkinson's disease, or ALS. The goal is to see if this scan can help underst…

This study aims to understand why Dupuytren's disease, a condition that causes fingers to curl into the palm, often comes back after surgery. Researchers will observe 80 patients during a specific surgical procedure to see if tiny nerves in the hand are involved in the disease re…

This study aims to understand why some adults develop gum recession after orthodontic treatment (braces). Researchers will follow 50 adult patients, some getting braces and some not, to measure gum health and identify risk factors. The goal is to create a clinical guideline to he…

This study aims to create a large collection of blood and tissue samples from people with skin cancer, along with their health information. It will enroll 7500 adults with melanoma or other skin cancers who agree to donate samples and share their medical history. The goal is to b…

This study aims to understand the basic skin reactions to common irritants like capsaicin (found in chili peppers) in healthy people. Researchers will apply creams to volunteers' feet and measure blood flow and pain to create a baseline. The goal is to gather knowledge that could…

This study aims to create a large collection of biological samples and health information from people with amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers will collect blood, urine, and tissue samples, along with detailed medical records, from …

This study aims to better understand how muscles are different in children with cerebral palsy (CP). Researchers will use special MRI and ultrasound scans to measure muscle size, stiffness, and fat content in 51 children, comparing those with CP to typically developing children. …

This study aims to see if a special 3D scan of the foot can predict how well a patient will recover from ankle or hindfoot surgery. Researchers will enroll 300 adults scheduled for reconstructive foot surgery. They will compare detailed movement data from the 3D scans taken befor…

This study aims to understand how ankle-foot orthoses (AFOs), a common type of leg brace, affect muscle activity in the legs of children with spastic cerebral palsy. Researchers will measure muscle signals in 30 children, aged 6 to 17, while they walk with and without their brace…

This study aims to create reliable methods for measuring trunk strength and balance in adults with spinal deformities. Researchers will compare 30 adults with spinal deformities to healthy volunteers to understand how the condition affects physical function. The goal is to build …

This study aims to collect thousands of colonoscopy videos and images of large colon polyps. Researchers will use this collection to develop artificial intelligence (AI) software. The goal is to train the AI to predict if a polyp has cancerous invasion, which could help doctors m…

This study aims to track 50 patients with infected hip replacements over time to better understand which treatments work best. Researchers will collect detailed information on patient outcomes, complications, and recovery to improve future care. The goal is to build a clearer pic…

This study aims to better understand how the body processes vitamin D. Researchers will compare levels of 'free' vitamin D—the active form the body can use—in healthy adults, pregnant women, and people with certain hormonal or kidney conditions. The goal is to see if measuring fr…

This study aims to understand how muscles grow and change in children with spastic cerebral palsy or a brain injury. Researchers will use 3D ultrasound scans to track muscle size, length, and structure in children's legs over two years. The goal is to learn how muscle development…