Heated milk ladder could speed up allergy tolerance in kids

NCT ID NCT06380673

Recruiting now Disease control Sponsor: Universitaire Ziekenhuizen KU Leuven Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether gradually introducing cow's milk in less-heated forms over 12 months helps children with milk allergy develop full tolerance faster than just eating well-cooked milk. About 90 children aged 1-18 who already tolerate heated milk will be split into groups: one follows a stepwise plan (shorter cooking times or a milk ladder), another sticks with only well-cooked milk, and a third group of healthy kids serves as a control. The goal is to see if the stepwise approach leads to more children being able to drink regular milk safely after a year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: heated cow's milk
What this could lead to: If it works, this could help children with cow's milk allergy develop full tolerance in about a year instead of several years, improving quality of life and reducing accidental reactions.
What could go wrong: This is an early-stage study with only 90 participants, so results may not apply to all children. There is a risk of allergic reactions during the stepwise introduction, and the approach may not work for everyone.

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Conditions

The condition(s) this trial relates to.

food allergy Heiner syndrome Milk Hypersensitivity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COW MILK ALLERGY FOOD ALLERGY

Contacts and locations

Locations

AZ Maria Middelares
RECRUITING

Ghent, Belgium
AZ Sint-Jan
RECRUITING

Bruges, Belgium
Imelda Hospital Bonheiden
RECRUITING

Bonheiden, Belgium
Jessa Hospital
RECRUITING

Hasselt, Belgium
UZ Leuven Gasthuisberg
RECRUITING

Leuven, Belgium

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