Universitaire Ziekenhuizen Ku Leuven

This study compares two small implants (XEN-63 and PRESERFLO) placed during a quick surgery to lower eye pressure in adults with open-angle glaucoma. About 166 participants will be randomly assigned to one implant and followed for 2 years. The goal is to see if PRESERFLO works as…

This study tests two drugs, bicalutamide and abemaciclib, in people with a specific type of advanced triple-negative breast cancer that has the androgen receptor. The goal is to see if the combination can stop the cancer from growing for at least 16 weeks. About 53 women with ino…

This study tests whether a program of nutrition, physical activity, and mindfulness can help women carrying twins deliver at least one week later than usual. Researchers will enroll 81 women with dichorionic twin pregnancies before 14 weeks. If the approach works, it could reduce…

This study is testing a new pacemaker, the Micra AV2, in 150 adults with heart block. The pacemaker is designed to better match the heart's natural rhythm, especially during exercise, and has a longer battery life. Researchers will check how well it works and if it is safe over 6…

This study tests a new care plan for older adults with chronic subdural hematoma, a type of brain bleed. The plan includes updated surgery techniques and aftercare. Researchers will compare 150 patients on the new plan to past patients to see if it lowers the chance of the bleed …

This study tests whether the drug guselkumab, alone or with a special diet, can help people with chronic pouchitis—a painful inflammation of the pouch created after ulcerative colitis surgery. Twenty adults who have not responded to antibiotics will receive treatment for 48 weeks…

This study tests whether a continuous glucose monitor (CGM) can improve pregnancy outcomes for women with gestational diabetes compared to standard finger-prick testing. About 386 women from Belgium and Australia will be randomly assigned to use either a CGM or a regular glucomet…

This study tests if a single low-dose radiation treatment to the whole heart can improve heart function in people with advanced heart failure. About 40 adults with severe heart failure who are not eligible for a heart transplant will receive this treatment. The goal is to see if …

This study tests whether a ketogenic diet (low-carb, high-fat) or ketone supplements can improve lymph vessel function and reduce swelling in people with lymphedema after arm lymph node surgery. About 81 adults with early-stage lymphedema will be randomly assigned to a ketogenic …

This study follows 50 people with ventricular tachycardia that hasn't responded to standard treatments. They receive a precise, one-time radiation treatment to the heart. Researchers will track how well it controls dangerous heart rhythms and any side effects over four years.

This study is for people with advanced stomach or gastroesophageal cancer that has a specific protein called CLDN18.2. It tests whether adding the drug Zolbetuximab to two standard chemotherapy drugs (Paclitaxel and Ramucirumab) helps patients live longer. About 100 adults who ha…

This study looks at which material works best to repair bone damage caused by gum disease. Thirty adults with deep gum pockets will receive one of four treatments during surgery: artificial bone with enamel proteins, artificial bone with hyaluronic acid, artificial bone with a bl…

This study tests whether a combination of two drugs, abemaciclib and letrozole, can shrink tumors in people with rare types of ovarian cancer that are fueled by estrogen. About 100 participants will receive the treatment to see how well it works and how safe it is. The goal is to…

This study tests whether adding a fasting-mimicking diet and exercise to standard chemotherapy and immunotherapy can improve treatment results for people with triple negative breast cancer. About 356 participants will be randomly assigned to either the lifestyle program or usual …

This study tests whether a gradual, stepwise introduction of heated cow's milk can help children with milk allergy develop full tolerance faster than simply avoiding milk. About 90 children aged 1-18 who already tolerate well-cooked milk will follow a 12-month plan of slowly redu…

This study tests whether children with eosinophilic esophagitis (EoE) can safely eat heated forms of hen's egg or cow's milk without their disease coming back. About 36 kids who are currently avoiding these foods will try gradually more heated versions over 8 weeks. The goal is t…

This study compares a new imaging tracer, [18F]-AlF-FAPI-74, with the standard [18F]-FDG in PET/CT scans for three inflammatory conditions: fever of unknown origin, IgG4-related disease, and axial spondyloarthritis. Researchers aim to see if the new tracer is as good or better at…

This study tests whether a vitamin E gel applied to early Dupuytren nodules can shrink them and prevent progression to disabling finger contractures. About 80 adults with stage 0 Dupuytren disease (palmar nodules but no finger bending) will receive either the gel or a placebo for…

This study tests whether the drug semaglutide can prevent type 2 diabetes in women who had gestational diabetes and now have high blood sugar after pregnancy. About 252 women will receive either semaglutide or a placebo for several months. The goal is to see if the drug lowers th…

This study looks at two strategies to prevent Crohn's disease from returning after bowel surgery. One group starts biologic therapy right after surgery, while the other group only starts it if a scope shows signs of disease coming back. The goal is to see if the wait-and-see appr…

This study compares a smartphone app called DOMINO to the strict low FODMAP diet for managing Irritable Bowel Syndrome (IBS). About 110 adults with IBS will use either the app or follow the low FODMAP diet to see which better reduces belly pain, bloating, and other symptoms. The …

This study tests whether using a CPAP breathing mask during radiation therapy for early-stage breast cancer can lower radiation doses to the heart and lungs. About 53 women with left-sided breast cancer will receive radiation with CPAP support. The goal is to reduce long-term hea…

This study tests a step-by-step rehabilitation program for people having back surgery for leg pain caused by a pinched nerve. The program includes exercises before and after surgery, early movement, and guidance on returning to work. Researchers want to see if this approach helps…

This study looks at whether adding tongue scraping to standard gum disease treatment helps reduce bad breath. Researchers will compare breath and gum health in 39 adults with periodontitis and halitosis. The goal is to see if this simple extra step improves breath odor more than …

This study looks at whether increasing the pacemaker rate during light exercise can lower pressure inside the heart for people with HFpEF, a condition where the heart struggles to relax. Researchers will measure heart pressures in 20 participants while they cycle, gradually raisi…

This study explores whether guided breathing exercises can help autistic young adults (ages 16-25) feel less stressed and improve their body's natural stress response, measured by heart rate. Participants will try two different breathing exercises and share how useful they found …

This study looks at whether robotic surgery is better than standard laparoscopic surgery for people with inflammatory bowel disease (IBD) who need colon or rectal surgery. Researchers will compare complications, pain, and recovery in 110 adults. The goal is to find out which appr…

This study looks at whether a 10-week plan with a leucine supplement is practical for children with spastic cerebral palsy. It also checks for early signs of muscle growth using ultrasound. Only 5 children will take part to see if they can stick with the supplement and if it affe…

This study looks at people with depression that hasn't improved with other treatments. If they don't get better after four sessions of one type of ECT (right unilateral), they will either continue with that type or switch to a different type (bitemporal). The goal is to see which…

This study looks at how the skin on the palm of the hand is involved in Dupuytren disease and whether it affects how well surgery works. Researchers will measure skin stiffness, use ultrasound, and examine tissue samples from 50 adults having surgery. The goal is to understand wh…

This study looks at how people who had surgery for bone or soft tissue sarcoma in their leg are doing afterward. Researchers will measure physical function, quality of life, and walking patterns in 60 adults who are at least one year past surgery. The goal is to better understand…

This study explores why some people develop nerve pain after chemotherapy by testing how the skin reacts to cinnamon and chili extracts. Researchers will measure blood flow in the fingers of healthy volunteers and cancer patients before, during, and after treatment. The goal is t…

This study aims to better understand pain in people with ADPKD, a genetic kidney disease. Over 60% of patients experience pain, often in the abdomen, back, or sides, and many are not satisfied with current treatments. Researchers will use simple sensory tests and questionnaires t…

This study is creating a biobank and data registry for people with amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers will collect blood, urine, tissue samples, and medical information from 505 participants over time. The goal is to store these ma…

This study looks at how ankle-foot orthoses (AFOs) change the way leg muscles work in children with cerebral palsy. Researchers will measure muscle activity while children walk with and without the brace. The goal is to better understand how AFOs affect movement, which could help…

This study looks at a hip condition called FAI, where extra bone growth causes pain during movement. Researchers will compare 99 men with and without symptoms to understand why some people feel pain and others don't. They use advanced motion capture and X-ray imaging to link hip …

This study aims to create a large collection of blood and tissue samples from people with skin cancer (melanoma and non-melanoma) and healthy volunteers. The goal is to store these samples and medical information for use in future research projects. No direct treatment is given; …

This study tests if a special ultrasound done through a scope (endoscopic ultrasound) can measure whether a common blood pressure pill (carvedilol) is working in people with liver scarring (cirrhosis). 24 adults will get the scope test before and after 3 months of treatment. The …

This study looks at what causes gums to pull away from teeth in adults, whether they have had braces or not. Researchers will measure gum health and bite patterns in 50 people to create a guide for predicting gum recession after orthodontic treatment. The goal is to help dentists…

This study aims to understand why some people get very sick from COVID-19 while others do not. Researchers will analyze blood samples and genetic information from 100 hospitalized adults with confirmed COVID-19. The goal is to identify immune system patterns and genetic factors l…

This study looks at whether ultrasound, a safe and painless imaging method, can help doctors better understand Dupuytren's disease—a condition that causes fingers to bend inward. Researchers will measure features like tissue brightness, skin involvement, and blood flow in 20 part…

This study looks at whether 3D dynamic models of the spine can help surgeons make better decisions when treating adolescent idiopathic scoliosis. Researchers will collect data from 100 patients aged 10-35 who are scheduled for surgery. The goal is to identify key 3D parameters th…

This study looks at how the skin on the feet reacts to natural compounds like cinnamon, mustard, and chili. Researchers will measure blood flow and any pain in 20 healthy adults. The goal is to better understand nerve function, which may help future research on diabetic nerve dam…

This study looks at how muscles grow and change in children with cerebral palsy (CP) by taking tiny samples from their leg muscles. Researchers want to connect these microscopic changes to what they see on scans and how the child moves. The goal is to better understand CP and fin…

This study uses a new ultra-high-resolution PET scanner to take detailed pictures of the brain and spinal cord in 300 healthy volunteers and people with conditions like Alzheimer's, Parkinson's, ALS, and psychotic disorders. The goal is to understand how small brain regions chang…

This study looks at whether a blood test that detects tiny bits of tumor DNA can help doctors better stage esophageal cancer and predict if it will come back after treatment. About 248 adults with resectable esophageal cancer will give blood samples before, during, and after thei…

This study explores whether a non-invasive test called Wideband Tympanometry can measure how well speech travels through the middle ear. Researchers will compare these measurements with speech understanding scores in 45 adults with normal hearing or conductive hearing loss. The g…

This pilot study will follow 12 first-time stroke patients who develop a stiff, turned-in foot (equinovarus). Researchers will use 3D ultrasound and special movement tests to measure changes in muscles, tendons, and nerves after a standard Botox injection. The goal is not to test…

This study tests a new PET scan tracer to measure levels of a protein called Hsp90 in the brain. Hsp90 helps proteins fold correctly, and problems with this process are linked to Alzheimer's, Parkinson's, and ALS. Researchers will scan 48 healthy volunteers and patients to see if…

This study focuses on liver cancer patients and aims to personalize their treatment. Researchers will use lab tests on tumor tissue and blood to find out which patients are likely to benefit from immunotherapy before starting treatment. This way, patients who won't respond can av…

This study aims to find genes that may increase the risk of developing pulmonary arterial hypertension (PAH) in people born with heart defects like atrial or ventricular septal defects. Researchers will test blood samples from 21 participants to look for known and new gene mutati…

This study is observing how muscles grow and change in children with spastic cerebral palsy. Researchers will use 3D ultrasound to measure muscle size and structure, and compare this to brain scans and movement abilities. The goal is to better understand the link between brain in…

This study aims to understand how adults with spinal deformities keep their balance while standing and walking. Researchers will use motion analysis, muscle activity tests, and quality-of-life surveys in 265 participants aged 45 and older. The goal is to improve future treatments…

This study observes 80 adults with Dupuytren disease who are having surgery to remove thickened tissue in their hands. Researchers want to see if tiny nerve bundles found in the tissue, and whether they are cut during surgery, affect the chance of the disease coming back. They wi…

This study looks at how different forms of vitamin D work in the body. Researchers will measure free vitamin D (the active form) in healthy adults, pregnant women, and people with hormone or kidney problems. The goal is to see if free vitamin D gives a more accurate picture of vi…

This study gives 10 people with stage III colon cancer two doses of the immunotherapy drug dostarlimab before their scheduled surgery. The main goal is not to cure or shrink the tumor, but to study changes in blood and tissue samples to find clues about which patients might respo…

This study looks at how botulinum toxin (Botox) injections change the muscles of children with spastic cerebral palsy. Researchers will use special imaging to measure muscle size, fat content, and stiffness. The goal is to understand the balance between the benefits of treatment …

This study tests whether a personalized discharge letter helps low-risk skin cancer patients feel more reassured and understand their condition better. About 150 patients will receive either standard advice or a tailored letter generated by an AI system and reviewed by a doctor. …

This study looks at whether a special 3D foot model can help predict and measure how well people recover after ankle and hindfoot reconstruction surgery. Researchers will compare walking patterns and foot pressure before and after surgery in 300 adults. The goal is to find out wh…

This study collects images and videos of large colon polyps during routine colonoscopies from 5000 people across multiple hospitals. The goal is to use these images to train an artificial intelligence (AI) system that can automatically predict whether a polyp has grown deep into …

This study aims to create reliable methods for measuring balance and trunk strength in adults with spinal deformity. Researchers will compare these patients with healthy volunteers to understand how the deformity affects function. The goal is to build a first-of-its-kind database…

This study follows 30 children who did not become tolerant to cow's milk after a previous treatment. Researchers want to see if these children naturally develop tolerance over time without any new treatment. The goal is to better understand how the body sometimes outgrows milk al…

This study looks at whether new AI tools can make adaptive radiotherapy—adjusting radiation plans during treatment—faster and easier for people with advanced lung cancer. Researchers will measure how long each step takes and compare plan quality using standard CT scans versus dai…

This study aims to create a large, detailed database of healthy Caucasian knees using advanced CT scans, X-rays, and ultrasound. Researchers will measure knee shape, ligament balance, and bone structure in 200 volunteers aged 20-35. The goal is to provide a reference for better u…

This study aims to understand why some people lose their sense of smell after a COVID-19 infection and why it doesn't come back. Researchers will collect tiny samples of tissue from inside the nose of 240 people—some with smell problems and some without—to look for differences in…

This study is tracking 500 people with smell or taste disorders to learn more about how these conditions affect daily life and how they change over time. Participants will complete standard tests and questionnaires during their regular clinic visits. The goal is to better underst…

This study tests whether wearing a heart monitor for 14 days can detect dangerous heart rhythms in people with mitral valve prolapse (a common heart valve condition) better than the usual 24-hour test. About 60 adults with MVP will wear a patch monitor for two weeks. The goal is …

This study is trying to understand why some people with severe flu in the ICU develop a dangerous fungal lung infection called aspergillosis. Researchers will compare the immune systems of 45 flu patients and non-flu pneumonia patients in the ICU. They hope to find differences in…

This study looks at how the bones in the shoulder joint touch each other in people with shoulder arthritis, both before and after they get a shoulder replacement. The goal is to find out why some shoulder implants loosen over time. Researchers will use special X-rays and CT scans…

This study follows 50 adults with infected hip replacements treated at University Hospitals Leuven. Researchers will collect data on infection clearance, surgical complications, and treatment strategies over time. The goal is to better understand which treatments work best and to…

This study tests a new tool that helps doctors check if a patient's reported antibiotic allergy is real, without needing skin tests. The goal is to safely remove or update incorrect allergy labels, allowing use of better first-line antibiotics. About 3,000 hospitalized adults wit…

This study looks at how weight-loss surgery changes blood sugar patterns during pregnancy and whether these changes increase the risk of having a smaller-than-normal baby. Researchers will use continuous glucose monitors to track blood sugar levels in 190 pregnant women, some wit…

This study is testing whether a simple nasal allergen challenge can help doctors decide when to start and stop allergy immunotherapy (allergy shots). Researchers will follow 200 adults with allergic rhinitis for up to 3 years, using the nasal test along with blood work and sympto…

This study aims to understand how the stomach and intestines digest food after bariatric surgery. Researchers will collect digestive samples and use a swallowable capsule that measures things like acidity and movement in the gut. The study includes people who have had gastric byp…