Universitaire Ziekenhuizen Ku Leuven

This study looks at how well automated insulin pumps (hybrid closed-loop systems) work for people with type 1 diabetes in real life. About 1,600 participants, including young children aged 2-6, will use these pumps for 24 months. The goal is to see if they help keep blood sugar i…

This study tests a custom-made knee implant (Episealer) for people with cartilage damage who haven't gotten better with other treatments. Four adults received the implant and will be followed for 10 years to check if it stays in place and helps with pain and movement. The goal is…

This study tests whether rinsing the nose with a solution containing xylitol (a natural sugar alcohol) can reduce sinus symptoms in adults with cystic fibrosis who also have chronic sinusitis. About 38 participants will try both xylitol rinses and standard saline rinses at differ…

This study looks at three types of total knee replacements in 75 people with severe knee arthritis. The goal is to see if a design that keeps the anterior cruciate ligament (ACL) helps patients move more naturally and feel better than designs that remove or replace it. Participan…

This study talks directly to people with implantable defibrillators and their partners to learn about their emotional, physical, and social challenges. Researchers will conduct one-on-one interviews with 250 participants to uncover unmet needs and barriers to care. The goal is to…

This study looks at 500 people with heart failure to see if using an ultrasound test (echocardiography) can better identify who benefits from a cardiac resynchronization therapy (CRT) device, a special pacemaker. Currently, 30-40% of patients who get a CRT don't improve. The stud…

This study examines how different patient characteristics and treatments influence the value of care for adult spinal deformity. Researchers will measure health outcomes and costs in 140 patients treated at University Hospitals Leuven. The goal is to understand what leads to bett…

This study follows 400 people who have an implantable cardioverter-defibrillator (ICD) to understand how their quality of life changes over time. Researchers will measure physical and emotional health, how well patients accept the device, and any concerns about daily activities. …

This study looks back at the medical records of 600 adults who received a single shot of morphine into the spine before surgery. The goal is to understand how often side effects like breathing problems, itching, and nausea happen. By learning more, doctors hope to make pain manag…

This study looks at why people with severe liver disease who are in the intensive care unit (ICU) are at risk for a dangerous fungal lung infection called invasive pulmonary aspergillosis. Researchers will study 450 patients to find better ways to predict, diagnose, and treat thi…

This study looks at how body fat influences breast cancer in 150 patients. Researchers will measure fat levels, analyze blood and tumor tissue, and track diet and activity. The goal is to better understand the link between obesity and breast cancer, not to test a new treatment.

This study looks back at data from 1,891 kidney transplant patients to understand why some transplants fail. Researchers want to create a decision-support system that helps doctors diagnose rejection earlier and choose better treatments. The goal is to improve long-term survival …

This study tests a camera that uses different colors of light to tell the difference between low-grade brain tumor tissue and normal brain tissue during surgery. Ten adults with suspected low-grade glioma will have the camera used during their tumor removal operation. The goal is…

This study looks at whether general anesthesia given to pregnant women for surgery might affect their child's intelligence and brain development. Researchers will compare children who were exposed to anesthesia before birth with those who were not. The goal is to understand any l…

This study looks at how much of the drug sugammadex crosses the placenta from mother to baby. Researchers will use donated placentas in a lab model to measure drug levels. The goal is to understand possible risks to the fetus when the drug is given during pregnancy. Sixteen place…

This study follows 88 working-age adults (63 or younger) who had knee replacement surgery to see how many return to work and how long it takes. Researchers use questionnaires to measure pain, knee function, and work ability over 1.5 years. The goal is to identify factors that hel…

This study looks at 40 people with early-stage Huntington's disease and healthy volunteers to see how well two types of brain scans can detect changes over 2 years. Participants get PET and MRI scans plus clinical exams at the start and after 2 years. The goal is to find better w…