Sugar alcohol rinse could soothe sinus pain in cystic fibrosis

NCT ID NCT05531630

ENROLLING_BY_INVITATION Symptom relief Sponsor: Universitaire Ziekenhuizen KU Leuven Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether rinsing the nose with a xylitol solution can reduce sinus symptoms in adults with cystic fibrosis. Participants will use both xylitol and standard saline rinses at different times to compare effects. The goal is to see if xylitol, a natural sugar alcohol, offers better relief for chronic sinusitis.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Xylitol

What this could lead to

If it works, this could offer a simple, low-cost way to ease chronic sinus symptoms in people with cystic fibrosis.

What could go wrong

This is a small early-stage trial with only 38 participants, so results may not apply broadly. Xylitol rinses may not work better than standard saline.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

chronic rhinosinusitis cystic fibrosis disease nasal cavity polyp

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC RHINOSINUSITIS (DIAGNOSIS)

Contacts and locations

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Locations

KU Leuven

Leuven, 3000, Belgium