Universitaire Ziekenhuizen Ku Leuven

This study will follow 100 adults who receive the 5C® MEDic Knee System during knee replacement surgery. Researchers want to see how long the implant lasts without needing another operation and track any complications over 5 years. Participants will also fill out health questionn…

This early-phase trial tests whether adding two targeted drugs (zanidatamab and tislelizumab) to standard chemotherapy can completely eliminate HER2-positive gastroesophageal cancer before surgery. About 29 adults with operable, locally advanced disease will receive the combinati…

This study compares the safety of the drug flecainide against standard treatments (sotalol or amiodarone) in about 988 adults with atrial fibrillation and stable coronary artery disease. Participants will be randomly assigned to one treatment and followed for at least a year to t…

This study tests whether a herbal medicine called STW 5-II can reduce gut inflammation and relieve symptoms like bloating and stomach pain in people with functional dyspepsia. About 100 adults recently diagnosed with this condition will take either STW 5-II or a placebo for 8 wee…

This study follows 200 adults with functional dyspepsia (stomach discomfort without a clear cause) who are prescribed itopride as part of their normal care. The goal is to see if itopride improves symptoms like fullness, bloating, and pain after meals over 8 to 16 weeks. Research…

This study looks at how knee braces and a surgery called high tibial osteotomy (HTO) change the bone structure and cartilage in people with knee osteoarthritis and misaligned legs. Researchers will use advanced imaging and computer models to measure these changes in 30 patients o…

This study looks at whether a harmless thermal camera can help doctors see how surgical wounds are healing after skin surgery. About 120 adults having skin lesions removed will have their wounds photographed with the camera. The goal is to catch problems like infection or slow he…

This study will follow 200 people who have had a complex or revision hip replacement at University Hospitals Leuven. The goal is to track how many need another surgery and why, and to improve care by learning from real-world results. No new treatment is being tested—this is an ob…

This study looks at young adults aged 18-35 with hip impingement, a condition that can lead to hip arthritis. Doctors often struggle to decide who should continue with non-surgical care and who needs surgery. The researchers will develop simple, clinic-friendly tests to help make…

This study looks at gut health in people with untreated Parkinson's disease compared to healthy adults. Researchers will check for changes in the gut lining, gut bacteria, and how food moves through the digestive system. The goal is to learn more about how Parkinson's affects the…