New triple therapy aims to wipe out HER2-positive stomach cancer before surgery

NCT ID NCT07477444

First seen Mar 19, 2026 · Last updated May 12, 2026 · Updated 5 times

Summary

This early-phase trial tests whether adding two targeted drugs (zanidatamab and tislelizumab) to standard chemotherapy can completely eliminate HER2-positive gastroesophageal cancer before surgery. About 29 adults with operable, locally advanced disease will receive the combination before and after tumor removal. The main goals are to check safety and see if the cancer disappears entirely in the removed tissue.

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