Crohn's patients may avoid unnecessary drugs after surgery, new study suggests

NCT ID NCT05169593

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether starting biologic drugs only after seeing signs of Crohn's disease on a colonoscopy is as good as starting them right after surgery to prevent the disease from coming back. About 292 adults with Crohn's who had bowel surgery will be randomly assigned to one of two approaches. If the wait-and-see approach works, it could mean fewer people need strong medications right away.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • AZ Damiaan

    RECRUITING

    Ostend, West-Vlaanderen, 8400, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • AZ Delta

    RECRUITING

    Roeselare, 8800, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • AZ Klina

    RECRUITING

    Brasschaat, 2930, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • AZ Maria Middelares

    RECRUITING

    Ghent, Oost-Vlaanderen, 9000, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • AZ Sint Lucas

    RECRUITING

    Ghent, 9000, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • AZ Sint Maarten

    WITHDRAWN

    Mechelen, 2800, Belgium

  • AZ Sint-Jan

    RECRUITING

    Bruges, 8000, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CHC Montlégia

    RECRUITING

    Liège, Liège, 4000, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CHU UCL Namur site Godinne

    NOT_YET_RECRUITING

    Yvoir, Namur, 5530, Belgium

    Contact Email: •••••@•••••

  • CHU de Liège

    RECRUITING

    Liège, Liège, 4000, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CHwapi

    RECRUITING

    Tournai, Henegouwen, 7500, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Careggi University Hospital

    RECRUITING

    Florence, 50134, Italy

    Contact Email: •••••@•••••

  • Cliniques Universitaires Saint Luc

    RECRUITING

    Brussels, Brussels Capital, 1200, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Erasmus ziekenhuis

    RECRUITING

    Brussels, Brussels Capital, 1070, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Humanitas research hospital

    NOT_YET_RECRUITING

    Milan, Rozzano MI, 20089, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • IRCCS De Bellis Castellana Grotte

    RECRUITING

    Castellana Grotte, 70013, Italy

    Contact Email: •••••@•••••

  • IRCCS San Raffael Hospital

    RECRUITING

    Milan, 20132, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Imeldaziekenhuis

    RECRUITING

    Bonheiden, 2820, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Jessa ziekenhuis

    RECRUITING

    Hasselt, 3500, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • OLV Aalst

    RECRUITING

    Aalst, 9300, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Sint lucas Brugge

    NOT_YET_RECRUITING

    Bruges, West-Vlaanderen, 8310, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • UZ Brussel

    RECRUITING

    Jette, Brussels Capital, 1090, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • UZ Gent

    RECRUITING

    Ghent, Oost-Vlaanderen, 9000, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • UZ Leuven

    RECRUITING

    Leuven, Vlaams-Brabant, 3000, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • UZA

    RECRUITING

    Edegem, Antwerpen, 2650, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Vitaz

    RECRUITING

    Sint-Niklaas, 9100, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • ZAS

    RECRUITING

    Antwerp, Antwerpen, 2018, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • ZOL Genk

    RECRUITING

    Genk, Limburg, 3600, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••