CROHN DISEASE

This study is for adults with Crohn's disease who did not get enough help from the standard dose of a drug called ustekinumab. It compares two approaches: adding another drug (upadacitinib) to ustekinumab, versus increasing the dose of ustekinumab alone. The goal is to see which …

This study looks at how well newer inflammatory bowel disease (IBD) medications work in children whose previous treatment (anti-TNF drugs) stopped working or didn't help. About 1,100 kids with Crohn's disease or ulcerative colitis will answer questions about their symptoms and pr…

This study looks at whether taking prebiotics (a type of fiber) can improve gut health and reduce symptoms in people with ulcerative colitis, a form of inflammatory bowel disease. About 70 adults with active symptoms will take a prebiotic supplement for 8 weeks. Researchers will …

This study is for people who have both an autoimmune disorder (like rheumatoid arthritis, lupus, or multiple sclerosis) and advanced cancer that has spread or cannot be removed. It tests a drug called nivolumab, which helps the immune system fight cancer, given alone or with othe…

This study looks at whether a drug called ustekinumab, combined with other treatments, can help people with Crohn's disease who have narrowed sections in their bowel. About 239 adults with moderate-to-severe Crohn's and symptoms of blockage will receive the treatment and be follo…

This study explores whether fecal transplants (capsules containing healthy donor stool) can improve quality of life and control inflammation in people newly diagnosed with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Crohn's disease, or ulcerative colitis. T…

This study tests whether combining a weight-loss medication (tirzepatide) with a special diet can help people with mild Crohn's disease who are already on biologic therapy. The goal is to see if this approach is practical and helps control symptoms. The study will enroll 24 adult…

This study compares two medications, guselkumab and risankizumab, to see which is more effective at controlling moderate to severe Crohn's disease. About 530 adults with active Crohn's will receive one of the two drugs. The main goal is to see how many achieve deep remission—mean…

This study is for children and young adults (ages 6–22) newly diagnosed with Crohn's disease who are starting infliximab. Researchers want to see if a computer program that calculates a personalized dose based on blood test results can help more patients achieve deep remission (n…

This study looks at two treatment paths for people with Crohn's disease who have a narrowed bowel (stricture) and symptoms like blockages. One group gets surgery early, while the other tries medication first and may have surgery later if needed. The goal is to see which approach …

This study tests whether a stem cell transplant using the patient's own cells can 'reset' the immune system in teens and young adults (ages 13-28) with severe Crohn's disease that hasn't responded to other treatments. The approach removes overactive immune cells and replaces them…

This study tests a new treatment for people with Crohn's disease who have complex anal fistulas that did not get better with standard care. The treatment uses donated stem cells injected into the fistula to reduce inflammation and help the tissue heal. The trial will check if the…

This study tests whether adding the drug vedolizumab after a stem cell transplant can help people with severe Crohn's disease stay in remission longer. About 50 adults with active Crohn's who have not responded to standard treatments will receive a stem cell transplant followed b…

This study looks at the long-term safety of tulisokibart, a medicine for moderate to severe Crohn's disease and ulcerative colitis. People who already took tulisokibart in an earlier study can join. Researchers will track side effects and how well people tolerate the drug over ti…

This study tests a personalized diet that removes refined and intolerant foods to help Crohn's disease patients stay in remission after bowel surgery. Researchers will track quality of life and nutrition in 35 participants over time. The goal is to develop a practical dietary pla…

This study tests whether the drug icotrokinra can reduce symptoms and gut inflammation in people with moderate-to-severe Crohn's disease. About 1,092 adults will receive either the drug or a placebo for up to 40 weeks. The goal is to see if icotrokinra helps achieve remission and…

This early-phase trial tests whether statins, a common cholesterol-lowering drug, can prevent the formation of strictures (narrowed areas) in the gut of adults with Crohn's disease. About 20 participants who are scheduled for surgery to remove strictures will take either a statin…

This program provides early access to upadacitinib for people with Crohn's disease, ulcerative colitis, certain types of arthritis, or atopic dermatitis. It is for those who have no other suitable treatment options and cannot join a clinical trial. A doctor must decide if the pot…

This study is testing whether transplanting healthy gut bacteria (in capsule form) can take hold in the intestines of people with Crohn's disease and possibly reduce inflammation. Researchers will enroll 120 adults with active Crohn's to see if the donor microbes engraft and if s…

This study follows 900 children aged 6-17 newly diagnosed with Crohn's disease to see how well their intestines heal after one year of anti-TNF therapy. Researchers will use blood tests, stool samples, colonoscopy, and special MRI scans to track healing. The goal is to understand…

This study tests whether treating Crohn's disease with a goal of healing all layers of the gut wall (called transmural healing) leads to better results than treating symptoms and blood markers alone. About 304 adults with moderate to severe Crohn's will be split into two groups: …

This study tests a remote monitoring app (MedicWise) for people with active Crohn's disease or ulcerative colitis. About 290 adults will use the app to track symptoms and health data, with the goal of spending more time in remission over 12 months. The app automatically collects …

This study tests whether removing the mesentery (a fatty tissue near the intestine) during surgery for Crohn's disease is safe and helps prevent the disease from coming back. About 30 adults with Crohn's who are on biotherapy and need ileocolic surgery will take part. The main go…

This study tests whether guselkumab can help people with Crohn's disease whose current treatment (ustekinumab) has stopped working. About 78 Chinese adults with active Crohn's will receive guselkumab and be followed for 48 weeks. The main goal is to see if their symptoms improve …

This study compares two treatments for children aged 6-18 with Crohn's disease: one group gets infliximab alone, another gets immunosuppressives alone, and a third gets both. The goal is to see which approach leads to more kids achieving remission (symptom-free and healed gut) af…

This study involves 25 adults with Crohn's disease who are scheduled for possible surgery. Researchers will use a special PET/MR scan with a collagen-binding tracer to see if it can accurately tell the difference between scar tissue (fibrosis) and active inflammation in narrowed …

This study collects images and videos from routine capsule endoscopy procedures to train an artificial intelligence system. The goal is to help doctors detect bowel diseases like Crohn's, celiac disease, and tumors more accurately and quickly. Up to 10,000 participants will contr…

This study tests a new tool: a capsule about the size of a fish oil pill attached to a string that takes pictures inside the lower gut. It is inserted without sedation and moves slowly upward using a motor. The goal is to see if it can get clear images of the lower GI tract in 30…

This study looks at whether starting biologic drugs only when a scope shows early signs of Crohn's coming back is as good as starting them right after surgery. About 292 adults with Crohn's disease who had surgery to remove a blocked part of the bowel will be randomly assigned to…

This study is testing a web-based tool that gives personalized risk estimates for Crohn's disease to people who have a close family member with the condition. The goal is to see if learning their personal risk motivates them to make healthy lifestyle and diet changes that might p…

This study looks at whether treating insomnia can improve sleep and possibly reduce pain and inflammation in people with Crohn's disease. About 83 adults with mild to moderate Crohn's and insomnia will receive a remote sleep intervention. The main goal is to see if the treatment …

This study tests a smartphone app called COBMINDEX that teaches stress-reduction skills to people with Crohn's disease. The goal is to see if the app can improve quality of life, reduce fatigue and pain, and help patients cope as well as working with a human therapist. About 200 …

This study tests whether a low dose of interleukin-2 (IL-2) is safe and can help control moderate-to-severe Crohn's disease. About 30 people aged 12 to 80 will receive the drug to find the best dose and check for side effects. The goal is to ease symptoms and improve quality of l…

This early-phase study tests whether a daily cranberry supplement can help rebalance gut bacteria in 50 adults with Crohn's disease. Participants take either the supplement or a placebo for 10 weeks, providing blood, urine, and stool samples. The goal is to see if cranberry compo…

This study looks at whether a special diet, called an adapted Crohn's disease exclusion diet with partial liquid nutrition, can improve quality of life for adults with Crohn's disease during a flare-up. About 52 participants will either receive standard medical care or this diet.…

This study tests whether far-infrared (fIR) therapy is safe and can help ease symptoms in people with Crohn's disease. Forty adults with active Crohn's will receive 10 sessions of either one of three intensities of fIR or a placebo treatment. Researchers will track side effects, …

This study looks at whether sleep changes can warn of a flare-up in people with Crohn's disease or ulcerative colitis. Researchers will track sleep patterns and disease activity in 216 patients in remission for one year. The goal is to find early signs of relapse, which could hel…

This study looks at how common exocrine pancreatic insufficiency (EPI) is in people with active Crohn's disease who are starting a new biologic therapy. EPI means the pancreas doesn't make enough enzymes to digest food properly. Researchers will check 50 adults at the start of tr…

This study is collecting blood, stool, and tissue samples from 200 children with inflammatory bowel disease (IBD) and other gut disorders to better understand what causes inflammation. Researchers will use advanced technology to study gene activity in the gut tissue. The goal is …

This study looks at why migraine is more common in people with autoimmune diseases like multiple sclerosis or rheumatoid arthritis. Researchers will measure immune cells and inflammatory markers in 396 women with and without migraine, including those with autoimmune conditions. T…

This study follows 450 adults who have early signs of inflammatory bowel disease (IBD) but no symptoms yet. Researchers want to learn how the disease progresses, what symptoms appear first, and how genetics and the immune system play a role. Participants are monitored over time w…

This study looks at bone health in teenagers recently diagnosed with Crohn's disease compared to healthy teens. Researchers use MRI and other scans to measure bone marrow fat and bone density. The goal is to understand how Crohn's disease affects bones early on, which could help …

This study is testing a new educational tool designed for people with melanoma who also have an autoimmune disease (like rheumatoid arthritis or Crohn's disease) and may receive immune checkpoint inhibitor drugs. Researchers want to see if the tool is easy to use and helpful for …

This study looks at how changes in gut bacteria may affect the energy use of immune cells in people with Inflammatory Bowel Disease (IBD). Researchers will compare healthy adults and IBD patients, giving healthy volunteers a short course of antibiotics to alter their gut bacteria…

This study looks at how nutrition and body composition (like muscle mass) influence treatment results in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will follow 300 patients starting new medical therapies or undergoi…

This study aims to find a better way to detect scarring in the intestines of people with Crohn's disease. Researchers will use a special dye and PET/CT scans to see active scarring, which current tests miss. The goal is to help develop new treatments that prevent permanent bowel …

This observational study looks for microplastics in children with and without inflammatory bowel disease (IBD). Researchers will collect tissue, stool, urine, and blood samples during routine procedures and use a special technique called Raman spectroscopy to detect and count mic…

This study aims to find biological markers in blood and tissue samples that can predict how patients with inflammatory bowel disease (IBD) will respond to a type of medication called TNF-alpha inhibitors. Researchers will compare samples from 100 adults, including healthy control…

This study looks at how having inflammatory bowel disease (Crohn's or colitis) as a child affects job and education in adulthood. Researchers will survey 460 adults diagnosed before age 17 to compare their work and school achievements with the general population. The goal is to u…

This observational study looks at the long-term safety of the drug ustekinumab compared to other biologic treatments in adults with Crohn's disease or ulcerative colitis. Researchers will analyze health records from the Department of Defense to track rates of cancer, serious infe…

This study follows 575 adults with Crohn's disease who have had part of their intestine removed. The goal is to better understand why the disease often comes back after surgery and to find ways to predict it. Researchers will collect medical history, blood, and tissue samples to …

This study is testing a new medical device that measures how nerves respond to inflammation in children with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The device checks three types of nerve fibers to help doctors better understand disease…

This study is looking at whether the unique mix of bacteria and fungi in the gut can help predict how well a person with Crohn's disease will respond to treatment. Researchers will collect stool, blood, and tissue samples from 100 adults in British Columbia during routine colonos…

This study tests a new wireless pill that measures temperature inside the gut. The goal is to see if it can help detect diseases like Crohn's disease. Ten healthy adults will swallow the capsule and researchers will check if it sends accurate temperature readings.

This study looks at whether robotic surgery is a good option for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. About 100 adults having minimally invasive surgery for IBD will take part. The goal is to see if robotic surgery is tec…

This study looks at people with Crohn's disease that is hard to treat, meaning their symptoms don't improve much with standard medicines. Researchers will track 1,400 adults in China to see how common this condition is and how well newer treatments work. The goal is to find out w…

This study compares the gut bacteria, fungi, and viruses in people with Crohn's disease, with or without arthritis, and healthy volunteers. Researchers aim to find biological markers that could explain why some Crohn's patients also develop arthritis. No treatment is given; the g…