CROHN DISEASE

This study is for adults with active Crohn's disease who are not getting better on their current standard dose of ustekinumab. It will test if adding a second drug (upadacitinib) works better and is as safe as simply giving a higher dose of the original drug. Researchers will com…

This program provides eligible patients with access to the drug upadacitinib for conditions like Crohn's disease, ulcerative colitis, and atopic dermatitis before it is officially approved in their country. A doctor must determine if the potential benefits for an individual patie…

This study is testing whether low-dose injections of a medication called IL-2 can help control moderate-to-severe Crohn's disease. Researchers will give daily injections for 8 weeks to 30 participants who haven't responded well to standard treatments. The main goals are to find t…

This study is observing how well the drug ustekinumab, as part of a broader treatment plan, helps people with Crohn's disease who have developed painful intestinal narrowings (strictures). It will follow 239 patients for up to two years to see if the treatment successfully contro…

This small pilot study is testing whether adding a weight loss medication called tirzepatide (Zepbound) and a specific diet to standard Crohn's treatment can improve disease control. It will enroll 24 adults with mild Crohn's disease who are overweight and already on stable biolo…

This early-stage study is testing whether injections of donor stem cells can help heal painful fistulas (abnormal tunnels) in people with Crohn's disease. The trial is for patients whose fistulas haven't improved with standard surgery and medication. Researchers will test two dif…

This study is testing whether a special type of infrared light, applied to the abdomen, can safely reduce inflammation and symptoms in people with Crohn's disease. Researchers will compare three different intensities of light therapy against a placebo treatment in 40 participants…

This study is testing if a specially designed diet can work as well as standard medications for improving quality of life during a Crohn's disease flare-up. It will compare the diet, which includes a nutritional drink, against usual drug treatments in 52 adults with active Crohn'…

This study aims to understand the long-term safety and effectiveness of the medication tulisokibart for people with moderate to severe Crohn's disease or ulcerative colitis. It's an extension study for 1,380 participants who previously benefited from tulisokibart in earlier trial…

This study is testing a new drug called icotrokinra for people with moderate to severe Crohn's disease, a chronic inflammatory bowel condition. It will involve about 1,100 participants to see if the drug can reduce symptoms and heal intestinal inflammation better than a placebo. …

This study is testing the safety and effects of the immunotherapy drug nivolumab in people who have both advanced cancer and an autoimmune disease like lupus, rheumatoid arthritis, or Crohn's disease. It will enroll 300 adults to see if the drug can help control their cancer whil…

This study is testing whether swallowing capsules containing processed, healthy donor stool (a gut bacteria transplant) can help people with active Crohn's disease. Researchers want to see if the new bacteria can successfully take hold in the gut and if this leads to reduced symp…

This study is testing whether a drug called infliximab works better alone or when combined with other immunosuppressive medications to control Crohn's disease in children. It will involve 128 children aged 6-18 who have active Crohn's disease. The main goal is to see which approa…

This study is testing a new dietary plan designed to help Chinese patients with Crohn's disease stay in remission after having bowel surgery. It aims to see if this specific diet can improve quality of life and nutritional health better than current approaches. The diet is based …

This study is testing whether robotic surgery can be used effectively for people with inflammatory bowel diseases like Crohn's and ulcerative colitis. Researchers will compare robotic surgery to standard laparoscopic (keyhole) surgery in 100 patients to see which approach works b…

This study tests an experimental stem cell transplant for young people with severe Crohn's disease that hasn't responded to standard medications. Doctors wipe out the overactive immune cells and replace them with the patient's own blood stem cells, aiming to 'reset' the immune sy…

This study is for people with severe Crohn's disease that hasn't improved with standard medications. It tests a two-part treatment: first, a stem cell transplant to 'reset' the immune system, followed by a drug called vedolizumab to help keep the disease under control. The goal i…

This study is testing whether aiming for 'transmural healing'—deep healing of the intestinal wall seen on ultrasound—leads to better results for people with moderate to severe Crohn's disease. About 304 participants will be randomly assigned to either have their treatment guided …

This study is testing whether taking prebiotic supplements for 8 weeks can improve the mix of gut bacteria and help control symptoms in people with ulcerative colitis. Researchers will enroll 70 adults with active symptoms and track changes in their gut health and inflammation ov…

This study is testing whether a modified surgical technique that removes more surrounding tissue (mesentery) during Crohn's disease surgery is as safe as the standard approach. Researchers want to see if this method reduces the high rate of disease returning after surgery. The tr…

This study aims to compare the long-term safety of ustekinumab against other biologic drugs for adults with Crohn's disease or ulcerative colitis. Researchers will use existing military health records to track over 1,000 patients who are starting these treatments. The main goal i…

This study is testing whether taking capsules containing processed stool from a healthy donor can help people newly diagnosed with certain inflammatory diseases like rheumatoid arthritis, Crohn's disease, or ulcerative colitis. About 200 participants will receive either these spe…

This study is testing whether a daily cranberry supplement can help improve gut health for people with Crohn's disease. Researchers want to see if the supplement can help balance gut bacteria and reduce inflammation. Over 10 weeks, 50 adults with Crohn's will take either the cran…

This study is testing whether a smartphone app that automatically tracks health data can help people with active Crohn's disease or ulcerative colitis. It aims to see if this remote monitoring helps patients stay in remission longer and reduces hospital visits compared to standar…

This study aims to develop artificial intelligence tools to help doctors analyze capsule endoscopy videos. Capsule endoscopy involves swallowing a tiny camera that takes thousands of pictures of the digestive tract. The AI is designed to spot potential problems faster and more ac…

This study is testing a new type of combined PET/MR scan that uses a special dye to find and tell apart scar tissue from inflammation in the bowels of people with Crohn's disease. The goal is to see if this scan can give doctors better information before surgery, potentially help…

This study is testing a new, low-cost tool to take pictures inside the lower intestines. The tool is a tiny capsule, about the size of a vitamin pill, attached to a thin string. Doctors will gently guide the capsule up the colon in awake participants to see if it can capture clea…

This study is testing a new web-based tool that gives people with a family history of Crohn's disease a personalized estimate of their own risk. Researchers want to see if receiving this risk information motivates healthy changes in diet, exercise, and smoking, and if those chang…

This study is testing whether treating insomnia in people with Crohn's disease can improve their sleep and potentially reduce other symptoms like pain and inflammation. Researchers are recruiting 83 participants with both Crohn's disease and insomnia to receive remote treatment. …

This study aims to understand how Crohn's disease affects bone health in teenagers. Researchers will compare bone marrow and bone density in 46 teens recently diagnosed with Crohn's disease against 46 healthy teens using MRI scans and blood tests. The goal is to learn if increase…

This study aims to better understand what causes migraine by investigating the immune system. Researchers will compare levels of specific immune cells and inflammatory signals in women with and without migraine, some of whom also have other autoimmune conditions. The goal is to g…

This study aims to understand how inflammatory bowel diseases (IBD) like Crohn's and colitis begin and progress, long before a person feels sick. Researchers will follow 450 adults for 10 years, focusing on those whose IBD was found during a routine colonoscopy before they had an…

This study aims to understand how a patient's nutritional status and body composition affect their treatment outcomes for Crohn's disease and ulcerative colitis. Researchers will observe 300 patients starting new medications or having surgery, measuring things like muscle mass an…

This study aims to find out if changes in sleep quality can serve as an early warning sign for flare-ups in people with Crohn's disease or ulcerative colitis. Researchers will monitor 216 patients who are currently in remission, tracking their sleep patterns with wrist-worn devic…

This study aims to discover if patterns in a person's gut bacteria can predict how well Crohn's disease treatments will work. Researchers will collect stool, blood, and tissue samples from 100 adults with Crohn's disease in British Columbia, comparing them to people without the c…

This study aims to understand how having Crohn's disease or ulcerative colitis as a child affects a person's job prospects and education level as an adult. Researchers will survey 460 adults who were diagnosed as children and compare their career and education outcomes to the gen…

This study is testing a new swallowable capsule that measures temperature inside the digestive tract. The goal is to see if this 'thermal capsule' can collect useful data that might one day help doctors spot diseases like Crohn's. Researchers are enrolling 10 healthy adults to sw…

This study aims to understand the connection between Crohn's disease and a type of arthritis by comparing the gut bacteria, viruses, and fungi in different groups of people. Researchers will analyze stool samples from 240 people: those with Crohn's disease only, arthritis only, b…

This study aims to understand how the community of bacteria in our gut (the microbiota) influences the energy levels of our immune cells, particularly in people with inflammatory bowel diseases (IBD) like Crohn's disease and ulcerative colitis. Researchers will compare 45 healthy…

This study is testing an educational tool designed to help melanoma patients who also have autoimmune diseases (like rheumatoid arthritis or Crohn's disease) understand their treatment options with immune checkpoint inhibitor drugs. Researchers want to see if the tool is easy to …

This study aims to find out how common pancreas problems are in people with active Crohn's disease. Researchers will measure this in 50 adults before they start a new biologic drug and again 14 weeks later. The goal is to understand if these digestive issues are linked to Crohn's…

This study aims to test a new imaging method to detect and track bowel scarring (fibrosis) in people with Crohn's disease. Researchers will use a special dye and PET/CT scans to see if they can spot early scarring and monitor its activity over time. The goal is to create a tool t…

This study aims to understand why some children with Crohn's disease heal completely after a year of standard anti-TNF therapy, while others do not. Researchers will follow about 900 children, ages 6-17, who are newly diagnosed. They will collect blood, stool, and genetic samples…

This study aims to find out if tiny plastic particles are present in children's bodies and if they are more common in kids with inflammatory bowel diseases like Crohn's or colitis. Researchers will analyze tissue, stool, blood, and urine samples from 40 children already scheduled…

This study aims to understand a specific type of Crohn's disease that doesn't respond well to standard medications. Researchers will follow 1400 patients in China for a year to see how common this hard-to-treat form is, how it differs from other cases, and what factors might pred…