Gut bacteria transplant could tame Crohn's inflammation

NCT ID NCT06631586

Recruiting now Disease control Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether capsules containing freeze-dried healthy donor gut bacteria can take root in the intestines of people with Crohn's disease. Researchers will check if the bacteria engraft in the ileum and colon, and explore changes in symptoms and inflammation. The trial involves 120 adults with active Crohn's disease who are already on stable treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fecal microbiota transplant (FMT) capsules
What this could lead to: If successful, this could point toward a new way to treat Crohn's disease by restoring healthy gut bacteria, potentially reducing inflammation and symptoms.
What could go wrong: This is an early phase 2 trial with only 120 participants, so results may not apply to everyone. The treatment may not engraft effectively or improve symptoms, and side effects like bloating or infection are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN DISEASE

Contacts and locations

Locations

NYU Langone Health
NOT_YET_RECRUITING

New York, New York, 10016, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55414, United States

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