Can a single drug ease Crohn's gut blockages?

NCT ID NCT05387031

Recruiting now Disease control Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether the drug ustekinumab (Stelara) can help people with moderate-to-severe Crohn's disease who also have bowel strictures (narrowing of the intestine). About 239 participants will receive ustekinumab and be followed for a year. The goal is to see if the drug can reduce symptoms, avoid the need for surgery or balloon dilation, and improve quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ustekinumab (Stelara)
What this could lead to: If successful, this could show that ustekinumab helps control Crohn's-related bowel strictures, reducing the need for surgery or dilation.
What could go wrong: This is an observational study, not a controlled trial, so results may be less definitive. The drug may not work for all types of strictures, and some patients may still need surgery.

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Conditions

The condition(s) this trial relates to.

Constriction, Pathologic Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN DISEASE INTESTINAL STRICTURE STRICTURE; BOWEL

Contacts and locations

Locations

Center of Inflammatory Bowel Disease, Department of Gastroenterology, the Second Affiliated Hospital, Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, 310009, China
Department of Gastroenterology, Affiliated Hospital of Yangzhou University
RECRUITING

Yangzhou, Jiangsu, China
Department of Gastroenterology, Chongqing Renji Hospital, University of Chinese Academy of Sciences
RECRUITING

Chongqing, Chongqing Municipality, China
Department of Gastroenterology, Huai'an First People's Hospital
RECRUITING

Huai'an, Jiangsu, China
Department of Gastroenterology, Second Affiliated Hospital of Soochow University
RECRUITING

Suzhou, Jiangsu, China
Department of Gastroenterology, Seventh Medical Center of PLA Army General Hospital
RECRUITING

Beijing, Beijing Municipality, China
Department of Gastroenterology, Sixth Affiliated Hospital, Sun Yat-Sen University
RECRUITING

Guangzhou, Guangdong, China
Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University
RECRUITING

Hangzhou, Zhejiang, China

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