Second Affiliated Hospital, School Of Medicine, Zhejiang University

This study tests whether adding a special type of radiation (SFRT) to standard treatment can help control non-small cell lung cancer that has started to grow again after initial therapy. About 25 adults with up to 5 progressing tumors will receive SFRT on those spots while contin…

This early-phase study tests a new treatment using immune cells from umbilical cord blood that are specially designed to target and kill cancer cells in people with a hard-to-treat type of T-cell lymphoma that has come back or not responded to prior therapy. About 45 adults aged …

This study looks at whether guselkumab can help people with moderate to severe Crohn's disease who did not get better with or could not tolerate another drug called ustekinumab. About 60 adults will receive guselkumab and be followed for 52 weeks to see if their symptoms improve …

This study is for people with high-risk multiple myeloma who have already completed initial treatment. It compares two maintenance therapies: a combination of ixazomib and a reduced dose of lenalidomide versus ixazomib alone. The goal is to see which approach better delays cancer…

This trial tests a new tool called VISOR that breaks up and removes kidney stones at the same time during surgery. It includes 20 adults aged 18-80 with stones 1-3 cm. The goal is to see if it clears stones safely, with a CT scan within 24 hours and a follow-up at 4 weeks.

This early-phase study tests a new treatment made from cord blood cells that are specially trained to find and attack B-cell lymphoma. The therapy, called IL-10/IL-15 CD19-CAR NK, is given to people whose lymphoma has not responded to or has returned after standard treatments. Th…

This study tests a new combination of liposomal irinotecan, fluorouracil, and either bevacizumab or cetuximab as a second treatment for people with advanced colorectal cancer that has spread. The goal is to see if this approach can shrink tumors and delay cancer growth. About 100…

This early-stage trial tests a personalized approach to deep brain stimulation (DBS) for people with severe depression that hasn't improved with other treatments. Researchers use brain scans and recordings to find the best spot and settings for each patient's implant. The goal is…

This study follows 120 people with early Alzheimer's or mild cognitive impairment who are taking lecanemab, a new FDA-approved drug that targets amyloid plaques in the brain. Researchers will track changes in thinking, daily function, and brain scans over 18 months, while also wa…

This study tests whether adding an immunotherapy drug (pucotenlimab) to standard chemoradiation can help shrink advanced rectal cancers before surgery. About 68 adults with locally advanced rectal cancer will receive the combination treatment. The goal is to see if more patients …

This study tests a new drug called envafolimab, given as a shot, combined with two chemotherapy drugs (doxorubicin and ifosfamide) as a first treatment for advanced soft tissue sarcoma. The goal is to see if this combination works better than chemo alone. About 25 adults with thi…

This study tests whether adding a PCSK9 inhibitor (a powerful cholesterol-lowering drug) to standard treatment can reduce major heart problems like heart attacks, strokes, or death in people with high-risk plaque in their coronary arteries. About 3,600 adults with specific plaque…

This study looks at 100 adults with moderate-to-severe Crohn's disease that has caused narrowing (strictures) in the bowel. Participants will receive either guselkumab or ustekinumab, and doctors will track their symptoms, imaging, and need for surgery over a year. The goal is to…

This early-phase trial tests a new treatment using specially engineered immune cells (CAR-NK cells) that target a protein called CD70 found on cancer cells. The study enrolls 25 adults with T-cell lymphoma or acute myeloid leukemia that has come back or not responded to standard …

This study tests whether fexofenadine hydrochloride, a common allergy medication, can improve long-term outcomes for people who have recently had a heart attack. About 2,800 adults who had a heart attack within the past week will receive either the drug or a placebo. Researchers …

This study looks at whether a drug called ustekinumab, combined with other treatments, can help people with Crohn's disease who have narrowed sections in their bowel. About 239 adults with moderate-to-severe Crohn's and symptoms of blockage will receive the treatment and be follo…

This study looks at whether giving radiation therapy after surgery can delay the return of early-stage tongue cancer in patients with certain risk factors. About 190 adults will be randomly assigned to receive either radiation or just regular check-ups. The goal is to see if radi…

This study is for people with breast cancer whose tumors did not shrink after two rounds of standard chemotherapy. Researchers want to see if adding a special type of radiation (SBRT) to the remaining chemotherapy can help eliminate the cancer more effectively. About 96 participa…

This early-stage trial tests a new method called PIPAC that sprays chemotherapy directly into the abdomen for people with colorectal cancer that has spread there. The study aims to find the safest dose and check for side effects. About 42 adults aged 18-75 with no other cancer sp…

This study tests whether combining two drugs—guselkumab and a JAK inhibitor (like upadacitinib or tofacitinib)—can help people with inflammatory bowel disease (IBD) that hasn't responded to standard treatments. About 80 participants aged 14-80 with moderate to severe IBD will rec…

This study tests whether ciprofol, a newer anesthetic, can prevent low blood pressure during surgery better than standard drugs. It involves 140 elderly patients (65+) who take long-term blood pressure medication and are having abdominal surgery. The goal is to see if ciprofol ke…

This study tests whether taking spirulina tablets before and after liver surgery can help protect the liver and speed up recovery. Thirty adults with bile duct cancer will take either spirulina or a placebo for three weeks before and after their operation. Researchers will measur…

This study tests a new type of radiation therapy (SFRT) given before surgery for people with large soft tissue sarcoma (at least 5 cm) in the arm, leg, or trunk. The goal is to see if this approach can improve the chance of staying cancer-free for at least one year. About 22 adul…

This study tests a new combination of drugs given before surgery for people with advanced head and neck cancer. The goal is to see if this approach can shrink tumors more effectively, potentially making surgery easier or even possible for some patients. About 76 adults with stage…

This study tests a new treatment for people who suddenly lose vision due to a blocked artery in the eye (retinal artery occlusion). Doctors will use a tiny needle to inject medicine directly into the eye's artery, combined with a standard eye surgery called vitrectomy. The goal i…

This study tests a new way to size heart valves during a procedure called TAVR for people with a specific type of bicuspid aortic stenosis (a heart valve condition). About 206 patients will be randomly assigned to either the new downsizing method or the standard sizing method. Th…

This early-stage trial tests a universal mRNA vaccine designed to target common mutations in high-grade gliomas, aggressive brain tumors. Ten participants with recurrent or progressive disease will receive the vaccine to see if it is safe and can boost the immune system to fight …

This early-stage trial tests an injection of special brain cells (GABAergic interneuron progenitors) in 6 adults with drug-resistant mesial temporal lobe epilepsy. The goal is to see if the treatment is safe and can reduce seizure frequency. Participants receive the cell therapy …

This study tests whether combining two drugs, cadonilimab and anlotinib, can help people with advanced or spreading soft tissue sarcoma whose first treatment stopped working. About 27 adults will take part. The goal is to see if the combo slows tumor growth and improves survival.

This study tests whether adding a new immunotherapy drug (iparomlimab and tuvonralimab) to standard chemoradiation can help control advanced head and neck cancer. About 27 adults with stage III-IVB disease will receive the combination. The goal is to see if it improves the chance…

This early-phase trial tests a new treatment called EPC-003, which uses specially engineered immune cells (CAR-T cells) to target two proteins found on glioblastoma cells. About 14 adults with recurrent or refractory glioblastoma will receive the therapy directly into the brain's…

This study is for people with solid tumors that have spread to the lining of the brain and spinal cord (leptomeningeal metastasis). Researchers want to see if combining whole-brain radiation with a chemotherapy drug (thiotepa) given into the spinal fluid, along with ongoing treat…

This study tests a device that sends mild electrical pulses to the spinal cord to help people with chronic spinal cord injury regain movement and sensation. Ten participants with injuries between T11 and L3 will receive the implant and be followed for 6 months. The goal is to see…

This study looks at whether using one closure device instead of two is just as safe for closing the blood vessel after a minimally invasive heart valve replacement (TAVR). About 876 people with severe aortic stenosis will take part. The goal is to see if using a single device can…

This study tests whether adding a chemotherapy drug (thiotepa) injected into the spinal fluid can improve outcomes for people with glioblastoma that has spread to the brain's lining or fluid spaces. About 38 adults will receive surgery, radiation, and standard oral chemo plus the…

This study looks at two ways to treat chronic coronary syndrome (narrowed heart arteries). One group gets a procedure to open blocked arteries, guided by a special CT scan. The other group gets only medicines. The goal is to see which approach prevents heart attacks, death, or th…

This study tests a new way to deliver anti-VEGF drugs directly into the cornea to treat abnormal blood vessel growth caused by herpes simplex keratitis. The approach aims to be more targeted and longer-lasting than current treatments. About 100 adults who have not had prior anti-…

This study tests whether a drug called leucogen can prevent severe neutropenia (dangerously low white blood cell counts) in people with early-stage hormone receptor-positive, HER2-negative breast cancer who are taking ribociclib and hormone therapy. About 94 participants will rec…

This study tests a drug called vebreltinib for people with advanced clear cell sarcoma, a rare cancer of soft tissues. About 30 participants will take the pill twice a day to see if it can shrink tumors or stop the cancer from growing. The study also compares their results to a g…

This study tests whether a robot guided by artificial intelligence can improve recovery for people with a moderate brain bleed (basal ganglia hemorrhage). About 330 adults who need surgery within 72 hours will be randomly assigned to robot-assisted or standard surgery. The goal i…

This study looks at whether giving iron to anemic patients before heart surgery improves their long-term recovery. About 400 adults with iron deficiency anemia having major heart surgery will get either iron supplements or standard care. Researchers will track quality of life, sl…

This study tests whether phycocyanin, a natural protein from spirulina, can reduce liver damage and stiffness in adults with liver fibrosis or cirrhosis. Ten participants will take either phycocyanin or a placebo daily for at least 4 weeks, with regular blood tests and ultrasound…

This study tests whether adding a chemotherapy drug (thiotepa) directly into the spinal fluid can prevent glioblastoma from spreading to the lining of the brain and spine. About 38 adults with newly diagnosed glioblastoma that touches certain brain areas will receive the drug alo…

This study is for people with HER2-positive early breast cancer. After starting standard treatment, doctors check how well the tumor is shrinking. If the response is not good enough, patients switch to a stronger combination of drugs. The goal is to see if this personalized appro…

This study tests a small device called iStent to lower eye pressure in 60 adults with open-angle glaucoma and cataracts. Participants will receive the implant during cataract surgery. The goal is to see if it safely reduces pressure and helps control the disease.

This study tests a personalized diet that removes refined and intolerant foods to help Crohn's disease patients stay in remission after bowel surgery. Researchers will track quality of life and nutrition in 35 participants over time. The goal is to develop a practical dietary pla…

This study tests whether adding the immunotherapy drug adbelimumab to standard chemotherapy and the targeted drug apatinib can help shrink esophageal cancer before surgery. About 35 adults with resectable stage II–IVA esophageal squamous cell carcinoma will receive this combinati…

This study tests a new drug called AK104 combined with standard chemotherapy and either cetuximab or bevacizumab for people with a specific type of advanced colorectal cancer (MSS type) that has not responded to initial treatment. The goal is to see if this combination can shrink…

This early-phase study tests a new treatment for B-cell lymphoma that has come back or not responded to standard care. The therapy uses a modified virus to deliver CAR-T/M cells directly into the body to attack cancer cells. About 48 adults aged 18 to 75 will take part to see if …

This study is testing whether adding leucine, a common amino acid found in food, to standard chemotherapy and radiation can help shrink tumors more effectively in people with locally advanced rectal cancer. About 33 adults will receive leucine alongside their usual treatment befo…

This study compares a newer, less invasive procedure called transcatheter aortic valve replacement (TAVR) using the J-VALVE system to traditional open-heart surgery for people with severe aortic regurgitation (a leaky heart valve). About 1,250 adults aged 65 and older with sympto…

This study tests whether a device that sends mild electrical pulses to the spinal cord, combined with daily rehab, can help people with chronic spinal cord injury regain walking ability. Twelve adults with partial paralysis will receive the implant and be followed for a year. The…

This study tests a new treatment using specially engineered immune cells (CAR-NK) for people with severe autoimmune diseases like lupus, scleroderma, and vasculitis that haven't responded to standard therapies. The treatment aims to control the overactive immune system and reduce…

This study is testing a new treatment called CD19/BCMA CAR-T cell therapy for people with multiple myeloma that has returned or stopped responding to standard treatments. The therapy uses a patient's own immune cells, modified to target two proteins (CD19 and BCMA) on myeloma cel…

This early-phase study tests a new immunotherapy using a patient's own immune cells, engineered to recognize a protein called CEA on cancer cells. The treatment is given after surgery to remove visible tumors in the abdomen. The goal is to find a safe dose and see if it can delay…

This study tests a stem cell transplant using a chemotherapy cocktail called TEAM for lymphoma patients whose cancer is likely to spread to the brain or spinal cord. About 45 adults who have already responded to initial treatment will receive their own stem cells after high-dose …

This study tests if a device placed near the spinal cord (epidural electrical stimulation) can safely improve movement and sensation in people with chronic spinal cord injury. Ten adults with injuries above the T10 level will receive the implant and undergo personalized stimulati…

This study tests a new approach for people with triple-negative breast cancer whose tumors did not shrink after initial chemotherapy. Participants receive a short course of high-precision radiation to the breast tumor, followed by immunotherapy (toripalimab) combined with more ch…

This early-phase study tests a new treatment called CAR-T cells, which are immune cells engineered to target a protein called CEA found on certain cancer cells. The study includes up to 48 adults with advanced non-small cell lung cancer or breast cancer that has not responded to …

This early-stage study is testing a new treatment called LILRA6 CAR-T for adults with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The treatment uses a patient's own immune cells, which are modified in a lab to better recognize and attack …

This study tests whether a drug-coated balloon works as well as a drug-coated stent for people having a severe heart attack (STEMI). About 1,244 adults will be randomly assigned to one of the two treatments. The goal is to see which approach leads to fewer heart-related problems …

This study tests whether using AI and robots to guide minimally invasive brain surgery helps people recover better after a hemorrhagic stroke (bleeding in the brain). About 1,000 adults with different types of bleeding will be randomly assigned to either the AI-assisted robotic s…

This study compares three ways of giving guselkumab to Chinese adults with moderate to severe plaque psoriasis: a high dose, an extended interval between doses, and the standard dose. The goal is to see which approach works best and is safest over 86 weeks. About 400 participants…

This study tests a new combination treatment for people with advanced liver cancer that cannot be removed by surgery. It combines a procedure that blocks the tumor's blood supply (TACE) with three immunotherapy drugs (sintilimab, bevacizumab, and ipilimumab). The goal is to see i…

This study uses artificial intelligence to analyze standard EKG results, aiming to more accurately diagnose hypertrophic cardiomyopathy (a thickened heart muscle) and tell it apart from other conditions that look similar. Researchers will enroll 15,000 adults, including those wit…

This study compares a new type of CT scanner (photon-counting) with a standard one to see if it can better detect very small blood clots in the lungs, called subsegmental pulmonary embolism. About 696 adults with suspected clots will get both scans. The goal is to see if the new …

This study tests an artificial intelligence (AI) tool that can screen for heart valve disease using standard chest CT scans that people already get for other reasons. The goal is to catch moderate-to-severe valve problems earlier without extra tests or radiation. Researchers will…

This study will collect MRI scans from 3000 adults with brain tumors (like gliomas or metastases) to train an AI system. The goal is to help doctors identify tumor types more accurately without surgery. If successful, it could reduce the number of biopsies needed.

This study aims to improve diagnosis and treatment for people with complex cataracts and eye structure problems. Researchers will create full 3D models of the eye using multiple imaging techniques to help surgeons plan better and predict outcomes. About 1,200 participants with le…

This study explores whether a non-invasive eye scan can detect Parkinson's disease in its early stages. Researchers will compare the scan's accuracy to standard PET imaging in 200 participants, including people with early Parkinson's, related conditions, and healthy volunteers. I…

This study aims to create a digital system that identifies older adults at risk for disability and helps prevent it. Researchers will screen 238 adults aged 65+ living in communities, then build a smartphone-based platform for assessment and intervention. The system will be teste…

This study tests whether a traditional Chinese medicine technique called acupoint application can help relieve constipation and qi deficiency in people with colorectal cancer who have had chemotherapy. About 106 adults will be randomly assigned to receive either the acupoint trea…

This study looks at whether people with moderate-to-severe inflammatory bowel disease (IBD) need to routinely take dexamethasone (a steroid) before receiving infliximab to prevent allergic reactions. Researchers will compare those who get the pre-medication as usual with those wh…

This study tests whether pressing tiny seeds on specific ear points, combined with a steroid drug, can prevent or reduce nausea and vomiting caused by a breast cancer treatment called trastuzumab deruxtecan. About 25 adults with breast cancer receiving palliative care will receiv…

This study tests whether giving patients a nerve block (a numbing injection) before ankle surgery can lower pain and help them recover faster. About 70 adults having ankle arthroscopy will be randomly assigned to receive either the nerve block or a placebo, and neither they nor t…

This study tests whether a non-invasive brain stimulation technique called iTBS can help reduce PTSD symptoms when added to standard care. About 140 adults with PTSD will receive the treatment, which uses magnetic pulses to target a brain area involved in movement and possibly em…

This study tests a new, faster type of brain stimulation called accelerated intermittent theta burst stimulation (AiTBS) to see if it relieves nerve pain better than standard treatment. About 120 adults with moderate to severe nerve pain will receive either AiTBS or standard 10-H…

This study looks at whether fecal microbiota transplantation (FMT) can reduce or prevent nausea, vomiting, and diarrhea caused by chemotherapy or targeted therapy in people with advanced gastrointestinal cancers. About 90 adults with stage IV cancer who are about to start their 4…

This study tests whether pressing small seeds on specific ear points, combined with a steroid drug, can prevent or reduce nausea and vomiting caused by chemotherapy in breast cancer patients. About 25 women who have had breast cancer surgery and need chemo will try this approach.…

This study tests whether a non-opioid pain medicine combination (celecoxib plus acetaminophen) works as well as standard opioid painkillers after ankle surgery. About 110 adults having minimally invasive ankle procedures will be randomly assigned to one of the two pain plans. The…

This study tests whether a shot in the buttock muscle works as well as an ultrasound-guided shot in the shoulder joint for treating frozen shoulder. About 528 adults aged 18 to 65 with frozen shoulder will receive one injection and be followed for 12 weeks. The goal is to see whi…

This study looks at whether special lenses that correct both cataracts and presbyopia (age-related blurry near vision) can help people with additional eye structure issues, like a loose lens or past eye surgery. About 320 adults will get these lenses during cataract surgery, and …

This study compares two treatments for early frozen shoulder (adhesive capsulitis): manipulation under anesthesia versus a supervised home rehabilitation program. Researchers will enroll 300 adults aged 40-80 with symptoms lasting 3 months or less. The goal is to see which approa…

This study is testing a single dose of a new pain medicine called tegileridine fumarate to find the best amount for controlling pain after orthopedic surgeries like hip or knee replacement. About 180 adults will receive the drug right after surgery, and researchers will adjust th…

This study tests whether pressing tiny seeds on specific ear points (auricular acupressure) plus a steroid drug (dexamethasone) can better prevent nausea and vomiting caused by chemotherapy in people with pancreatic cancer. About 25 participants will receive the treatment before …

This study is testing whether a non-invasive brain stimulation technique called intermittent theta-burst stimulation (iTBS) can reduce symptoms of social anxiety disorder. About 100 adults with social anxiety will receive either real iTBS to the left or right prefrontal cortex, o…

This study follows 10,000 adults with heart valve disease to understand how the condition progresses and what factors influence it. Researchers will use imaging tests like echocardiograms, CT scans, and MRIs, along with medical history and lifestyle information. The goal is to pr…

This study looks at 450 people with central lung cancer who need a type of surgery called sleeve lobectomy. Researchers want to see if using a robotic system (RATS) leads to better long-term survival and recovery compared to the standard video-assisted method (VATS). The goal is …

This study looks at gum tissue from people with aggressive periodontitis, chronic periodontitis, and healthy gums to understand what makes the aggressive form different. Researchers will use advanced genetic techniques to map out the types of cells and their activity in the tissu…

This study follows 1,850 people with bronchiectasis, a chronic lung condition, for three years. Researchers collect sputum samples monthly to analyze how bacteria in the lower airways evolve and adapt. The goal is to understand which bacterial changes lead to sudden worsening of …

This study looks for early biological markers in the blood that could predict dry mouth in head and neck cancer patients before symptoms appear. Researchers will collect blood samples from 126 patients before and after radiation therapy and use advanced techniques to find these m…

This study follows thousands of liver transplant recipients and living donors over many years to find out what health problems may arise after surgery. Researchers will collect medical data and ask participants about their well-being. The goal is to create better follow-up care p…

This study watches 330 people with dilated cardiomyopathy (an enlarged, weak heart) to see if problems in the heart's tiny blood vessels lead to worse outcomes like heart failure or death. Researchers will track major heart events over time. No treatment is given—only observation…

This study looks at how X-ray radiation used during cancer surgery changes red blood cells. Researchers will test blood from 20 patients to see if radiation damages the cells' shape, flexibility, or ability to carry oxygen. The goal is to find safe radiation levels for treating b…

This study tests a new method to monitor how deep a patient is under anesthesia during surgery. Instead of using standard monitors, researchers will analyze chemicals in the patient's exhaled breath to predict anesthesia depth. The goal is to find a non-invasive way to manage ane…

This study tests whether high-density brain recordings can decode Mandarin Chinese speech features, including tone, from imagined speech. About 50 adults with brain conditions like epilepsy or tumors will have temporary electrodes placed during surgery, and 10 people with severe …

This study looks at whether two weight-loss medications, semaglutide and tirzepatide, can slow or reverse aging in the genes of adults with obesity. Sixty-six participants will take one of these drugs or metformin for 24 weeks. Researchers will use a special test called iWatchAge…

This study looks at why some people with idiopathic normal pressure hydrocephalus (iNPH) improve after a brain shunt surgery while others do not. Researchers will analyze spinal fluid and brain scans from 40 older adults before and after surgery to find biological markers that pr…

This study uses powerful 7T MRI brain scans and visual perception tests to find biological markers for severe mental disorders like major depression, schizophrenia, and bipolar disorder. Researchers will compare 320 patients and healthy volunteers aged 18-45 to improve diagnosis …

This study aims to create an artificial intelligence system that can predict if and where breast cancer will spread to other parts of the body, such as the bones, lungs, liver, or brain. Researchers will analyze tumor samples and health data from 2,000 women with breast cancer to…

This study looks at how the brains of 25 stroke patients with weak hand muscles work when they do mirror movements. Researchers use a special brain scanner to measure activity. The goal is to learn more, not to test a treatment.

This study looks at how two common endoscopic treatments—band ligation and sclerotherapy—change blood pressure in the liver's portal vein over 3 to 6 months in people with cirrhosis. Researchers will use a special ultrasound-guided technique to measure these pressure changes. The…

This study is building an artificial intelligence (AI) system that uses PET/CT scans and patient information to identify different types of lung cancer. The goal is to help doctors tell small cell from non-small cell lung cancer and further classify subtypes without needing a bio…

This observational study will use artificial intelligence to analyze stored tumor tissue samples from 400 women with breast cancer. The goal is to see if the AI can accurately predict which patients are at risk of the cancer spreading (metastasis) within 5 years after surgery. No…

This study follows 500 people who are already scheduled for minimally invasive shoulder or knee surgery for sports injuries like torn ligaments or rotator cuff tears. Researchers will collect information about each person's injury, surgery, and recovery over two years to learn wh…