Second Affiliated Hospital, School Of Medicine, Zhejiang University

This study tests two drug combinations for people with advanced colorectal cancer that has a specific genetic change called KRAS G12C. In one group, patients who haven't had treatment yet will receive the drugs IBI351 and cetuximab β plus chemotherapy (FOLFIRI). In another group,…

This study tests whether giving the immunotherapy drug serplulimab together with chemotherapy before surgery can help shrink non-small cell lung cancer and improve outcomes. About 36 adults with stage IIA to IIIB lung cancer will receive the combination, then have surgery to remo…

This study tests whether repeatedly inflating a blood pressure cuff on the arm (called remote ischemic conditioning) can improve thinking and memory in people who have had a stroke or have small vessel brain disease. Eighty participants will receive the treatment twice daily for …

This early study tests whether beta-sitosterol, a plant-based supplement, can safely help people recover from a severe type of stroke called subarachnoid hemorrhage. Forty adults who have had this stroke will take the supplement for six months. The study will check for side effec…

This phase 3 trial tests whether adding the immunotherapy drug sintilimab to standard chemotherapy and bevacizumab helps people with a specific type of advanced colorectal cancer (RAS-mutant, MSS) live longer without their cancer growing. About 446 adults who have not had prior t…

This study compares two common injections—platelet-rich plasma (PRP) and corticosteroids—given during arthroscopic rotator cuff repair. 387 adults with full-thickness supraspinatus tears are randomly assigned to receive PRP, corticosteroid, or a placebo injection during surgery. …

This study tests whether using a shockwave device (intravascular lithotripsy) along with standard artery preparation can improve outcomes for people with moderate to severe coronary artery calcification. About 1,096 participants will be split into two groups: one gets standard pr…

This study tests whether icaritin soft capsules, taken daily for up to a year, can help prevent liver cancer from coming back in patients who had surgery to remove their tumor. Twenty adults with high-risk features for recurrence will take the capsules twice a day. The main goal …

This early-phase trial is testing a personalized vaccine made from a patient's own tumor proteins. The goal is to see if it's safe and can help prevent esophageal cancer from coming back after surgery and standard therapy. 27 patients who have completed initial treatments will re…

This study tests whether adding the drug serplulimab to standard chemotherapy before surgery can help people with a certain type of esophageal cancer. The goal is to shrink tumors more effectively and lower the chance of cancer coming back. About 48 adults with stage II to IVA es…

This phase II trial tests a targeted cancer drug called orelabrutinib combined with either low-dose radiation or another drug (rituximab) in 39 people with a rare eye lymphoma (ocular adnexal MALT lymphoma). The goal is to see how well the combination shrinks tumors and how safe …

This study tests whether a combination of stereotactic (computer-guided) surgery and a clot-dissolving drug can help people recover from a deep brain hemorrhage. The trial enrolls 380 adults with small-to-moderate bleeds in the basal ganglia who have significant disability. The g…

This study tests a new procedure called VISOR against the standard surgery (PCNL) for removing kidney stones that are 2 to 4 centimeters in size. About 170 adults will be randomly assigned to one of the two surgeries. The main goal is to see how many people are stone-free within …

This study is testing an artificial intelligence system that can identify snake species from photos taken by patients or witnesses. The goal is to help emergency doctors quickly know whether a snake is venomous and which species it is, so they can give the right treatment faster.…

This study tests a new shoulder support device designed to prevent shoulder subluxation (partial dislocation) in people who have had a stroke and have weakness on one side. Eighty first-time stroke patients will use either the new device or a standard sling during early rehabilit…

This study tests a small device that sends gentle electrical pulses to nerves far from the head (called Ultra-Distal TENS) to see if it can reduce migraine pain and related symptoms like nausea and sensitivity to light or sound. About 206 adults with frequent migraines will use t…

This study compares a new adaptive fluidics system to traditional methods during cataract surgery. The goal is to keep eye pressure stable and reduce risks. About 320 adults with lens diseases will take part. The new system adjusts fluid flow in real time to avoid sudden pressure…

This study looks at gene activity in brain tissue removed during surgery from 10 people with temporal lobe epilepsy and hippocampal sclerosis. The goal is to find which genes are linked to the disease and may help predict outcomes. No new treatment is being tested; instead, resea…

This study involves 3,600 people who have had a heart stent placed. Researchers want to see if a special cholesterol test (VAP) can help predict when the artery narrows again. Participants provide a blood sample from routine care, and no extra blood draws are needed. The goal is …

This study looks at whether computer analysis of PET/CT scans can help doctors more accurately stage non-small cell lung cancer and predict genetic mutations. Researchers will use data from 500 patients to build and test machine learning models. The goal is to provide better, per…