Second Affiliated Hospital, School Of Medicine, Zhejiang University

This study tests whether a 4-week course of the antibiotic TMP-SMX (Bactrim) can reduce the number of serious COPD flare-ups in people whose lungs carry Pneumocystis jirovecii, a common fungus. Researchers will compare the antibiotic to a placebo in 630 adults with advanced COPD …

This study tests a combination of two drugs, glofitamab and selinexor, in 30 adults with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) who have already tried at least two other treatments. The goal is to see how many patients achieve a complete response (cancer dis…

This study tests whether removing some blood during bone cancer surgery and replacing it with fluid (acute normovolemic hemodilution) can reduce the need for donor blood transfusions. The trial will include 420 adults undergoing elective bone cancer surgery. The goal is to see if…

This study tests whether teprenone, a stomach-protecting drug, can reduce gastrointestinal damage caused by high-dose steroids in people with lupus. One hundred participants will be randomly assigned to take either teprenone or the standard acid-blocker omeprazole for 12 weeks. T…

This study compares two types of special glasses (DIMS and DOT) to control nearsightedness in children aged 6 to 12 who also have intermittent exotropia (a type of eye misalignment). Researchers want to see which lens works better and whether the glasses affect eye coordination. …

This early-phase trial tests a combination of three drugs—TAS-102, bevacizumab, and serplulimab—in 20 people with metastatic colorectal cancer who have already had surgery to remove tumors. The goal is to see if the combination is safe and can delay cancer progression. Participan…

This study will follow 264 adults with frequent gout flares to see how often attacks return within 24 weeks after starting firsekibart. Researchers will also track side effects and how quickly flares resolve. The goal is to understand if this medication helps control gout in ever…

This study looks at whether taking Firsekibart regularly (every 4 weeks) is better than using it only when a gout flare starts. It involves 118 adults who had no flares during 24 weeks of initial treatment. The goal is to see which approach prevents more gout attacks over the nex…

This study tests whether an artificial intelligence (AI) program can improve follow-up care for people who had emergency surgery for a torn aorta (aortic dissection). About 1,314 adults will be randomly assigned to either standard follow-up or AI-guided follow-up, where the AI pr…

This phase II trial is testing whether adding an immunotherapy drug (QL1706) to standard chemotherapy before surgery can help shrink tumors in women with early-stage cervical cancer (stages IB1-IB3). About 50 participants will receive the combination, then undergo conservative su…

This study looks at whether starting blood thinners (DOACs) is safe and effective for people who have had a stroke, but also have a history of a brain bleed and an irregular heartbeat (atrial fibrillation). About 852 participants will be randomly assigned to receive either a bloo…

This study tests whether leaving the needle biopsy track in place during sarcoma surgery is as safe as removing it. The goal is to see if avoiding extra tissue removal can lower complications without increasing the chance of the cancer coming back. About 3,300 people with sarcoma…

This study tests whether the drug finerenone can help people with heart failure who have had a heart valve replacement (TAVI). About 2,800 older adults will be randomly assigned to receive finerenone or a placebo. The goal is to see if the drug lowers the chance of death or worse…

This trial tests whether the Adacolumn device, which filters certain white blood cells from the blood, can reduce brain swelling in people who have had a severe stroke. Ten patients will receive the treatment within 24 hours of their stroke. The goal is to see if it prevents wors…

This study tests whether combining an anti-IL-17A/F antibody (bimekizumab) with a non-ablative fractional laser can safely reduce symptoms of mild to moderate hidradenitis suppurativa, a chronic skin condition causing painful lumps. Fifty adults will receive the combination every…

This phase 2 trial will test whether adding the experimental drug ivonescimab to standard chemotherapy before surgery can improve outcomes for people with resectable esophageal squamous cell carcinoma. About 49 participants will receive three cycles of the combination, then under…

This early-phase trial tests a new gene therapy for Parkinson's disease. Six participants will receive a virus-based treatment injected into a specific brain area during surgery. Afterward, they take a drug to control abnormal brain activity and improve movement. The main goal is…

This study tests whether a medicine given as a nose spray before a heart stent procedure can reduce heart muscle injury or heart attack. About 1800 adults scheduled for elective stent placement will receive either the medicine or a placebo spray. Researchers will measure heart da…

This study tests whether a drug-coated balloon (DCB) is as safe and effective as a drug-eluting stent (DES) for treating large blockages in heart arteries. About 2,492 patients will be randomly assigned to receive either a balloon or a stent, guided by advanced imaging. The goal …

This study tests two experimental drugs, MRG003 and QL1706, together in people with cervical cancer that has returned or spread and no longer responds to standard chemotherapy. About 41 adults will receive the combination to see if it shrinks tumors. The goal is to control the di…

This study tests whether specially designed viruses, called bacteriophages, can eliminate persistent infections around orthopedic implants like hip or knee replacements. One hundred adults with such infections will receive the virus solution directly into the infected area after …

This Phase 3 trial tests whether combining two drugs, tofacitinib and imatinib, can safely clear the painful pustules of palmoplantar pustulosis (PPP), a rare chronic skin disease on the palms and soles. About 135 adults with moderate-to-severe PPP will receive either the combo o…

This study tests a new way to treat Helicobacter pylori (H. pylori) infections that didn't get better with the first round of antibiotics. Instead of using a scope to take a stomach sample, doctors will use a stool test to find which antibiotics will work best. About 531 adults w…

This study tests whether using a laser along with ultrasonic cleaning works as well as the standard manual scraping plus ultrasonic cleaning for treating advanced gum disease. About 174 adults with severe periodontitis will receive one of the two treatments on different sides of …

This early study tests whether a second infusion of a patient's own modified immune cells (CAR-DC) is safe and can improve heart function in 5 adults with end-stage dilated cardiomyopathy. Participants had already received one dose but saw their heart function worsen again. The g…

This study will test whether using wipes with a special antibacterial solution (chlorhexidine gluconate) before surgery can reduce bacteria on the skin better than standard cleaning. It involves 40 men with urethral stricture who are scheduled for reconstructive surgery. Research…

This phase 2 trial tests a new combination of drugs—lisafotoclax, decitabine, and homoharringtonine—in 35 adults with acute myeloid leukemia (AML) whose cancer did not respond to or could not tolerate the standard venetoclax/azacitidine regimen. The goal is to see if this new mix…

This study tests a new treatment for people with a rare disease called light-chain cardiac amyloidosis that has come back or not responded to other treatments. The treatment uses specially engineered immune cells (CAR-NK cells) from donated umbilical cord blood to target and atta…

This study tests whether a combination of three drugs (camrelizumab, chemotherapy, and ivarmacitinib) given before surgery can help people with a type of esophageal cancer. The goal is to see if the treatment can eliminate or shrink the tumor enough to improve surgical outcomes. …

This study will test whether a lower dose of the drug lecanemab works as well as the standard dose for people with early Alzheimer's disease. Researchers will compare brain scans, memory tests, and blood markers in 140 participants over 18 months. The goal is to find the most eff…

This early-stage trial tests a new cell therapy for people with heart failure caused by blocked arteries. The treatment uses the patient's own immune cells, engineered to target scar tissue in the heart. The study will check safety and whether it can improve heart function in 15 …

This study tests a combination of three drugs (Benmelstobart, Anlotinib, and low-dose Cyclophosphamide) in 40 women whose ovarian, fallopian tube, or peritoneal cancer has come back. The goal is to see if this mix can keep the cancer from growing for longer. Participants must be …

This phase 2 trial tests a combination of three drugs—liposomal irinotecan, temozolomide, and bevacizumab—in 24 people with soft tissue sarcoma that has returned or not responded to prior treatment. The goal is to see if the combination can slow or stop tumor growth. Participants…

This study tests whether adding a bone-strengthening drug (bisphosphonate) to a standard antibiotic (vancomycin) can better control chronic bone infections that are hard to treat. About 280 adults with a specific type of bone infection will be randomly assigned to get either the …

This study tests a drug called everolimus in people with advanced colorectal cancer that has a specific genetic change (CDK12 deficiency) and has not responded to other treatments. The goal is to see if the drug can shrink tumors or slow the cancer's growth. About 38 adults will …

This early-stage study tests a new cell therapy called CNK-UT009 in 40 people with severe inflammatory bowel disease (Crohn's or colitis) that hasn't improved with standard treatments. The main goal is to check safety and find the best dose, while also looking at how well it work…

This study tests whether a new mouthwash called Amphion can improve gum health when used after standard deep cleaning for periodontitis. Sixty adults with gum disease will receive either Amphion or a placebo mouthwash to use at home twice daily. The goal is to see if the mouthwas…

This early-phase trial tests a new treatment for people in shock after a severe heart attack. The therapy uses specially engineered immune cells (CAR-DC) to target a protein found in heart scar tissue, aiming to calm the immune response. The study will enroll 18 patients and prim…

This study tests a drug called mavacamten in 132 people with hypertrophic cardiomyopathy (thick heart muscle) that blocks blood flow in the middle or tip of the heart's main pumping chamber. The goal is to see if mavacamten can reduce the pressure difference across the blockage a…

This phase 2 trial tests a combination of sintilimab (an immunotherapy), bevacizumab (a targeted therapy), and chemotherapy (albumin-bound paclitaxel plus gemcitabine) as a first treatment for people with advanced bile duct cancer that cannot be surgically removed. The study aims…

This early-stage trial tests a new cell therapy for people with end-stage idiopathic pulmonary fibrosis (IPF), a disease that causes severe lung scarring and breathing failure. The therapy uses specially engineered immune cells to target and reduce scarring in the lungs. The stud…

This early-phase trial tests whether tendon stem cells can help rotator cuff tears heal better after surgery. About 107 adults with small to medium tears will receive either standard repair or repair plus stem cells placed at the injury site. The study will check for side effects…

This study tests a treatment called photodynamic therapy (PDT) for women with low-grade cervical precancer caused by HPV types 16 or 18. A photosensitizing cream is applied to the cervix, then activated with light to destroy abnormal cells. The trial will compare 225 women who re…

This study compares a light-activated gel treatment (ALA-PDT) to standard surgery (LEEP) for women with high-grade cervical precancer (HSIL/CIN2). About 560 women will receive either the gel plus red light therapy or surgery. The goal is to see if the gel treatment works as well …

This study compares two common fertility treatments—ICSI and IVF—to see which one helps couples with unexplained infertility have a baby. About 848 couples in China will be randomly assigned to one treatment. The main goal is to find out which method leads to more live births.…

This study compares three ways to handle the dental pulp (tooth nerve) after transplanting a wisdom tooth to replace a damaged molar. 360 people aged 18-40 will be randomly assigned to receive either standard root canal treatment weeks after surgery, a special root tip procedure …

This phase 2 trial tests whether the drug surufatinib, taken daily for 6 months after surgery, can prevent neuroendocrine tumors from coming back in high-risk patients. It will enroll 35 adults with stage III tumors (including G1, G2, and all G3 types). The main goal is to see ho…

This study compares two types of surgery for people with early-stage thyroid cancer located in the isthmus (the middle part of the thyroid). One group will have a smaller surgery called extended isthmusectomy, which removes only the tumor and nearby lymph nodes. The other group w…

This study tests a drug called ivarmacitinib for people with polymyalgia rheumatica, a condition causing muscle pain and stiffness. The goal is to see if it can control the disease without needing steroids. About 80 adults aged 50-75 will take either the drug or a placebo, and re…

This early-phase trial tests a new type of immunotherapy for recurrent glioblastoma, an aggressive brain cancer. The treatment uses a patient's own immune cells, engineered to target a protein called EGFRvIII found on tumor cells, and modified to work better in the tumor's enviro…

This study tests two injected medications, bleomycin and pingyangmycin, for treating plantar warts. Each of the 200 adult participants will receive both drugs on different warts to compare which works better. The main goal is complete clearing of the warts, with follow-up for 36 …

This study tests whether adding the blood thinner rivaroxaban to standard aspirin and clopidogrel can improve sluggish blood flow in heart attack patients who just had a stent placed. About 60 adults will receive either the triple therapy or standard dual therapy for one month. R…

This study is testing whether adding a probiotic called Lactobacillus johnsonii to standard chemotherapy and immunotherapy can help control advanced lung, breast, or stomach cancers. About 156 adults aged 18-75 will be randomly assigned to receive either the probiotic or a placeb…

This study will test the antibody drug lecanemab in 120 people with mild cognitive impairment or mild-to-moderate Alzheimer's disease. Using PET scans to measure amyloid and tau proteins in the brain, researchers hope to identify which patients are most likely to benefit from tre…

This study tests whether eating foods high in resistant starch (a type of fiber) can slow down memory and thinking problems in people who have a high genetic risk for cognitive decline. Seventy adults aged 40 and older with obesity or large waistlines will eat either high-resista…

This study will develop and test an artificial intelligence (AI) model to predict the risk of a heart attack within 6 months in people who have already had one. Researchers will combine different types of patient data to create a more accurate risk score. The goal is to identify …

This study is testing a new blood test called TuFEst that uses DNA fragments and deep learning to stage breast cancer and check if it has spread to lymph nodes. Researchers will enroll 269 breast cancer patients, including those having surgery and those receiving chemotherapy bef…

This study will test whether artificial intelligence can analyze non-contrast breast MRI scans to detect cancer early, avoiding the need for contrast agents that can be costly and risky. Researchers plan to enroll 30,000 women aged 30-70 and compare AI readings to standard radiol…

This study looks at whether the drug amisulpride can prevent nausea and vomiting after gynecological laparoscopic surgery. About 526 patients will receive the drug after surgery and be monitored for 24 hours to see if they avoid vomiting or needing extra medication. The goal is t…

This study tests whether a long-acting numbing drug (liposomal bupivacaine) can reduce pain for up to 72 hours after open upper abdominal surgery. 148 adults having liver, stomach, or pancreatic surgery will get either the long-acting drug plus standard numbing, or standard numbi…

This study tests whether a long-acting form of the numbing drug bupivacaine (liposomal bupivacaine) can reduce pain and the need for strong opioid painkillers after lung transplant surgery. 88 adults receiving a double lung transplant will get an intercostal nerve block either wi…

This study compares three approaches to ureteral stenting after kidney stone surgery: no stent, a stent removed after 1 week, and a stent removed after 2 weeks. Researchers will track complications, patient comfort, and recovery in 90 adults with upper urinary tract stones. The g…

This study tests if a special augmented reality (AR) training program can improve vision in people aged 12 to 55 with lazy eye (amblyopia). It compares the AR method to the standard treatment of patching the stronger eye. The goal is to see if the AR approach is safer and more ef…

This study tests a non-invasive device that gently stimulates a nerve in the ear to reduce anxiety in people having major abdominal surgery. Over 282 participants will either get the real stimulation or a sham version for 60 minutes daily, starting two days before surgery. The go…

This study tests whether papaverine, a drug that relaxes blood vessels, can relieve nerve pain and numbness caused by taxane chemotherapy. About 43 adults whose symptoms haven't improved with standard treatments will receive daily infusions of papaverine for up to three weeks. Th…

This study tests whether a gentle electrical stimulation of the ear (taVNS) given before a standard epidural steroid injection can improve pain relief for people with cervical radiculopathy—a pinched nerve in the neck causing arm pain. Eighty adults will be randomly assigned to r…

This study tests a new surgical approach for women with early breast cancer who need a nipple-sparing mastectomy. If cancer is found in the nipple during surgery, doctors will remove the nipple but try to save the pigmented skin around it (the areola) and rebuild a new nipple rig…

This study tests whether butylphthalide, a drug used for stroke, can improve symptoms of Multiple System Atrophy (MSA), a rare and serious brain disorder. About 150 adults with MSA will take either the drug or a placebo three times a day for six months. Researchers will track sym…

This study will compare three types of anesthesia for people having ankle surgery: total intravenous anesthesia with a nerve block, general anesthesia with a nerve block, and spinal anesthesia. The goal is to see which method allows patients to recover and leave the hospital the …

This study tests whether a gentle electric current applied to acupuncture points can improve memory and thinking in people who have had a stroke. 110 adults with mild to moderate cognitive problems will be randomly assigned to receive either real or sham electroacupuncture, plus …

This study tests whether combining virtual reality mindfulness therapy with mild brain stimulation can help treat depression that occurs after a stroke. Researchers will enroll 120 adults aged 18-65 who had a stroke at least 4 weeks ago and have moderate to severe depression. Par…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people with acute ankle sprains heal better and faster. Researchers will enroll 208 people with recent ankle sprains and compare those who get hyperbaric oxygen to those w…

This study compares two minimally invasive procedures for treating narrowed sections of the small intestine caused by Crohn's disease. About 100 participants will receive either a balloon dilation or a precise incision made during a special endoscopy. The goal is to see which app…

This study compares two methods to keep the surgical area clear during ankle arthroscopy: using a dilute epinephrine solution versus a traditional tourniquet. About 88 people with chronic ankle instability or ligament injuries will be randomly assigned to one method. The goal is …

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce pain and the need for strong painkillers after complex spinal surgery. About 98 adults having major back surgery will be randomly assigned to receive either the real stimulati…

This study tests whether adding a Chinese herbal formula called Liqin Zhike to standard asthma inhalers (ICS/LABA) can reduce the chance of cough returning in people with cough variant asthma. About 236 adults aged 18 to 70 who are newly diagnosed will take either the inhaler alo…

This study tests if a long-lasting numbing drug (liposomal bupivacaine) injected into the scalp before surgery can reduce pain after a specific type of brain surgery called microvascular decompression. About 100 adults having this surgery will be randomly assigned to receive eith…

This study will test CGRP-targeted medications in 2,000 Chinese adults with vestibular migraine, a condition causing severe vertigo and dizziness. The goal is to see if these drugs can reduce the severity and frequency of attacks, both as immediate treatment and for prevention. P…

This study will collect information from 400 people having surgery for bone cancer. The goal is to track complications like infections or blood clots and understand how to improve care. By analyzing this data, researchers hope to find ways to make surgery safer and recovery faste…

This observational study will test whether an artificial intelligence algorithm can accurately detect heart sounds using data from a wearable ECG patch in 50 people with heart failure. Participants will wear the patch and have their heart sounds recorded with a digital stethoscop…

This study aims to improve the accuracy of single-lead ECG recordings from a wearable patch by using a new algorithm that also analyzes heart sounds. Researchers will compare the patch's readings to the standard 12-lead ECG in 50 adults with abnormal heart conduction intervals. T…

This study tests a computer system called LingBao that helps doctors decide the best treatment for people having a stroke. About 3,000 adults from 20 stroke centers will take part. The system uses patient data to give treatment suggestions, but doctors make the final call. The go…

This study looks at whether changes in how the pupils react to light can predict recovery in critically ill patients. Researchers will measure pupil responses daily for the first week in the ICU. They aim to see if these measurements relate to how well patients do at discharge an…

This study tests a new approach called Episodic Future Thinking (EFT) to encourage physical activity in older adults with motoric cognitive risk syndrome (MCR), a condition that raises the risk of dementia. Researchers will randomly assign 166 participants to receive EFT or a con…

This study will look at 1,280 people who had colon polyps removed to find better ways to predict if polyps will come back. Researchers will combine lifestyle information, blood markers, and past medical records to build a risk prediction model. The goal is to improve follow-up sc…

This simulation study tests whether a 'Digital Twin' lung display—a 3D animation of lung function—can reduce mental workload and speed up diagnosis for doctors managing breathing machines. Thirty-four ICU physicians will handle four simulated breathing emergencies, once with stan…

This study aims to create an artificial intelligence (AI) system that can combine medical images (like CT and MRI scans) with patient records and lab results to help doctors more accurately diagnose diseases of the liver, gallbladder, and pancreas. The researchers will use data f…

This study will follow 110 people with myopic choroidal neovascularization (mCNV), a complication of severe nearsightedness that can cause vision loss. Researchers will use deep learning to analyze eye scan images and build a model that predicts how well patients respond to anti-…

This study looks at how a new pain medicine called Anrikefon works in older adults after laparoscopic belly surgery. Thirty people aged 65 and older will receive the drug and have their blood tested to measure drug levels. The goal is to understand how the drug behaves in older b…

This study will create a biobank by collecting blood, tissue, and bile samples from 300 adults with liver, bile duct, or pancreatic tumors, as well as from people with benign conditions and healthy volunteers. No experimental treatments or extra procedures are involved—samples ar…

This study will develop a new AI-powered model to predict major heart problems after a heart attack. Researchers will analyze data from over 1,500 patients who had a heart attack and received a stent. The goal is to create a more accurate tool than current methods to identify pat…

This study compares two types of ventilators (breathing machines) used when moving patients who are on life support within or between hospitals. The goal is to see if a new ventilator (TV80) keeps oxygen levels as stable as a standard one (HAMILTON-T1). About 98 adults will be ra…

This study surveys over 13,000 healthcare providers in Chinese emergency rooms to measure their knowledge of pain and sedation guidelines and how well they follow them. The goal is to find gaps in training and practice, which could lead to better patient care. No treatments are t…