Second Affiliated Hospital, School Of Medicine, Zhejiang University

This study tests whether eating foods with resistant starch (a type of fiber) can slow down memory loss in people at high genetic risk for cognitive decline. About 70 adults aged 40 and older will either eat high-starch foods or regular starch foods daily. Researchers will track …

This early-stage study tests whether a second infusion of a patient's own modified immune cells (CAR-DC) can safely improve heart function in people with end-stage dilated cardiomyopathy, a condition where the heart is enlarged and weak. The cells target a protein called FAP to c…

This study tests the drug everolimus in people with advanced colorectal cancer that has a specific genetic change (CDK12 deficiency) and has not responded to other treatments. The goal is to see if the drug can shrink tumors or slow the cancer's growth, and to find the safest dos…

This early-phase trial tests a new treatment made from specially engineered immune cells (CAR-DC) for people who have had a severe heart attack and are in shock. The treatment targets a protein called FAP to calm harmful inflammation. The study will enroll 18 adults and primarily…

This early-phase trial tests a gene therapy for Parkinson's disease in 6 adults aged 40-70 with advanced symptoms. A specially designed virus is injected into a brain area called the subthalamic nucleus to calm overactive nerve cells. After surgery, patients take a drug to activa…

This study tests whether combining two drugs, tofacitinib and imatinib, can safely treat moderate-to-severe palmoplantar pustulosis (PPP), a rare skin disease causing painful pustules on the palms and soles. About 135 adults will receive either the drug combination or a placebo f…

This study tests a new drug called Ivonescimab, combined with chemotherapy, given before surgery to people with a type of esophageal cancer that can be removed. The goal is to see if this combination can shrink or eliminate the tumor before surgery, improving long-term outcomes. …

This study tests whether the drug surufatinib can help prevent neuroendocrine tumors (NETs) from returning after surgery. It enrolls 35 adults with stage III NETs who are at high risk of recurrence. Participants will take surufatinib after their operation, and researchers will tr…

This early-stage trial tests a new cell therapy for people with end-stage idiopathic pulmonary fibrosis (IPF), a severe lung scarring disease. The therapy uses specially engineered immune cells to target and calm the cells that cause scarring. The study will check if the treatmen…

This study compares a light-based treatment called photodynamic therapy (PDT) to a common surgical procedure (LEEP) for women with high-grade cervical lesions (HSIL/CIN2) caused by HPV. The goal is to see if PDT is as effective as surgery at clearing these abnormal cells, while p…

This study tests whether specially designed viruses (bacteriophages) can wipe out stubborn bacterial infections in people with orthopedic implants like joint replacements. About 100 participants will receive the virus treatment, and doctors will check if the bacteria are gone aft…

This study looks at whether it's safe to leave the needle biopsy tract in place during surgery for extremity sarcoma. Currently, surgeons often remove the tract to prevent cancer cells from spreading, but this may not be necessary. The trial will compare cancer recurrence rates i…

This study tests whether combining an anti-IL-17A/F antibody with a special laser can safely reduce symptoms of mild to moderate hidradenitis suppurativa, a chronic skin condition causing painful lumps. About 50 adults will receive the combination treatment every 4 weeks for 16 w…

This study tests whether a new mouthwash called Amphion can improve standard gum disease treatment. About 60 adults with periodontitis will use the mouthwash along with deep cleaning. The goal is to reduce plaque and gum bleeding without relying on antibiotics.

This study looks at whether keyhole (laparoscopic) surgery or traditional open surgery leads to better long-term outcomes for colon cancer patients who have extra fat around their internal organs (visceral obesity). About 664 adults aged 18 to 75 with confirmed colon cancer will …

This study looks at the best way to handle the dental pulp (tooth nerve) when using your own healthy wisdom tooth to replace a damaged molar. Researchers will compare three strategies: standard root canal weeks later, a special root-tip treatment during surgery, or just trimming …

This study tests whether adding a probiotic called Lactobacillus johnsonii to standard chemotherapy and immunotherapy can help control advanced lung, breast, or stomach cancers. About 156 adults aged 18-75 will be randomly assigned to receive either the probiotic or a placebo alo…

This early-phase trial tests a new type of immune cell therapy (CAR-T) for people with recurrent glioblastoma, an aggressive brain cancer. The therapy is designed to target a specific protein (EGFRvIII) found on cancer cells and includes a metabolic boost to help the cells work b…

This study tests a combination of three drugs (Benmelstobart, Anlotinib, and Cyclophosphamide) in 40 adults with recurrent ovarian, fallopian tube, or primary peritoneal cancer. The goal is to see if this treatment can control the disease and improve survival. Participants must h…

This study tests whether giving a combination of three drugs (camrelizumab, chemotherapy, and ivarmacitinib) before surgery can help people with a type of esophageal cancer. The goal is to shrink or eliminate tumors before removal, potentially improving outcomes. About 45 adults …

This study tests if a drug-coated balloon is as safe and effective as a drug-coated stent for treating large blockages in heart arteries. About 2,492 adults with coronary artery disease will be randomly assigned to one of the two treatments. Doctors will use special imaging to gu…

This study tests a drug called ivarmacitinib for people with polymyalgia rheumatica, a condition causing muscle pain and stiffness. The goal is to see if it can control the disease without needing steroids. About 80 adults aged 50-75 will take either the drug or a placebo, and re…

This study tests whether monoclonal antibody drugs can slow Alzheimer's disease progression in 120 people with mild cognitive impairment or mild Alzheimer's. Researchers will use PET scans to measure brain proteins and see which patients benefit most. The goal is to better target…

This study looks at whether a lower dose of the medication lecanemab can control Alzheimer's disease as well as the standard dose. Researchers will compare brain scans, thinking tests, and blood markers in 140 people with early-stage Alzheimer's over 18 months. The goal is to fin…

This study tests a drug called mavacamten in 132 people with hypertrophic cardiomyopathy (HCM) that blocks the lower part of the heart. The goal is to see if the drug reduces pressure inside the heart during a breathing maneuver over 36 weeks. Participants must have a thickened h…

This study tests a new combination of three drugs (lisafotoclax, decitabine, and homoharringtonine) in 35 adults with acute myeloid leukemia (AML) whose cancer did not respond to or could not tolerate a common first treatment. The goal is to see if this new mix can shrink or elim…

This study compares two common fertility treatments—ICSI and IVF—to see which leads to more live births for couples with unexplained infertility. About 848 couples in China will be randomly assigned to one method. The goal is to help doctors choose the best first treatment for th…

This study tests a new treatment using specially trained immune cells (CAR-NK cells) from donated umbilical cord blood to fight a rare, serious heart condition called light-chain cardiac amyloidosis. The cells target two proteins (BCMA and CD19) on the harmful cells. The trial in…

This study tests a light-activated drug (ALA-PDT) against simply watching and waiting for cervical low-grade lesions linked to HPV types 16 or 18. About 225 women aged 20-60 will take part. The goal is to see if the therapy can make the lesions disappear and clear the virus, pote…

This study tests whether adding bisphosphonates (a bone-strengthening drug) to the standard antibiotic vancomycin can better control chronic bone infections that are hard to treat. About 280 adults with a specific type of bone infection will be randomly assigned to receive either…

This study tests whether the drug finerenone can help people with heart failure who have had a heart valve replacement (TAVI). About 2,800 participants will be randomly assigned to receive either finerenone or a placebo. The goal is to see if the drug reduces the chance of death …

This early-stage study tests whether a person's own tendon stem cells can improve healing after rotator cuff repair surgery. About 107 adults with small to medium tears will receive the cell treatment during surgery. The goal is to see if it is safe and helps the tendon heal stro…

This study tests whether using a laser with ultrasonic cleaning works as well as the standard manual scraping plus ultrasonic cleaning for treating advanced gum disease. About 174 adults with severe periodontitis will receive one of the two treatments. The goal is to see if the l…

This early-stage trial tests a new treatment for people with severe heart failure from blocked arteries. It uses a patient's own immune cells, modified to target scar tissue in the heart and calm harmful inflammation. The main goals are to check safety and see if it can improve h…

This study tests a device called Adacolumn that filters certain white blood cells from the blood. The goal is to see if it can reduce dangerous brain swelling in people who have had a severe stroke. Ten adults with a large blocked artery in the front part of the brain will receiv…

This study tests a combination of two drugs (MRG003 and QL1706) in 41 adults with recurrent or metastatic cervical cancer that worsened after platinum-based chemotherapy. The goal is to see how many patients' tumors shrink or disappear. Participants must have measurable tumors an…

This study tests a combination of three drugs (liposomal irinotecan, temozolomide, and bevacizumab) in 24 people with advanced soft tissue sarcoma that has come back or not responded to prior treatment. The goal is to see if the combo can slow tumor growth and how safe it is. Par…

This study tests if giving a nose spray of dexmedetomidine before a heart procedure (PCI) can reduce heart injury or heart attack. About 1800 adults will receive either the drug or a placebo spray. Researchers will check blood markers and track heart events for 30 days to see if …

This study tests whether adding the blood thinner rivaroxaban to standard aspirin and clopidogrel can improve slow blood flow in heart attack patients who just had a stent placed. About 60 adults will receive either the triple therapy or standard dual therapy for one month. Resea…

This study tests a combination of chemotherapy, an immunotherapy drug, and a diabetes drug (sitagliptin) in people with a specific type of advanced colorectal cancer. The goal is to shrink tumors before surgery. About 138 adults aged 18-75 with locally advanced, non-metastatic co…

This early-phase study tests a new cell therapy called CNK-UT009 in 40 people with severe inflammatory bowel disease (Crohn's or colitis) that hasn't improved with standard treatments. The main goal is to check safety and find the best dose. Researchers will also look for early s…

This study compares two surgeries for people with early-stage thyroid cancer located in the isthmus (the middle part of the thyroid). One group will have a smaller surgery that removes only the tumor and nearby lymph nodes, while the other group will have the entire thyroid remov…

This study tests whether icaritin soft capsules, taken after surgery, can help prevent liver cancer from coming back in patients at high risk for recurrence. About 25 adults will receive the treatment and be monitored for tumor response and side effects. The goal is to improve lo…

This study is testing a new, non-invasive method to treat stubborn H. pylori stomach infections. Researchers will use a stool test to identify which antibiotics the bacteria are resistant to, then prescribe a personalized combination. The goal is to see if this tailored approach …

This study aims to develop an artificial intelligence (AI) model that can predict the risk of a heart attack within the next 6 months. Researchers will collect and analyze data from 1500 adults who have already had a heart attack and received a stent. The goal is to create a more…

This study tests a new blood test that uses artificial intelligence to analyze DNA fragments. The goal is to see if it can accurately determine the stage of breast cancer and whether it has spread to lymph nodes, potentially reducing the need for surgery. The study will enroll 26…

This study aims to see if an artificial intelligence (AI) model can accurately detect early breast cancer using MRI scans that do not require a contrast dye injection. Researchers will collect MRI images from 30,000 women aged 30-70 and train the AI to find cancer signs. If succe…

This study tests two drugs, bleomycin and pingyangmycin, injected directly into plantar warts. Each of the 200 adult participants will have half their warts treated with one drug and half with the other, so the treatments can be compared directly. The goal is to see which drug cl…

This study tests a new procedure using a balloon-assisted scope to make a small cut in narrowed areas of the small intestine caused by Crohn's disease. It compares this to the standard balloon stretching method. The goal is to see which approach better relieves symptoms and reduc…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce pain and the need for strong painkillers after complex spinal surgery. About 98 adults will be randomly assigned to receive either the real stimulation or a sham (fake) versio…

This study explores a new surgical option for women with early-stage breast cancer who are having a nipple-sparing mastectomy. If cancer is found in the nipple during surgery, doctors will remove the nipple but try to save the areola and rebuild a new nipple right away. The goal …

This study tests whether injecting a long-lasting numbing medicine (liposomal bupivacaine) into the scalp before brain surgery can reduce pain afterward. About 100 adults having a specific type of brain surgery (microvascular decompression) will be randomly assigned to get either…

This study tests whether a drug called butylphthalide can improve symptoms of multiple system atrophy (MSA), a rare brain disorder. About 150 adults with MSA will take either the drug or a placebo for 6 months. Researchers will measure changes in movement and daily function to se…

This study compares three types of anesthesia for people having ankle arthroscopy (a minimally invasive surgery). The goal is to find which method helps patients wake up and go home the fastest. Two hundred adults aged 18 to 65 will be randomly assigned to receive either total in…

This study looks at whether combining virtual reality mindfulness therapy with a gentle brain stimulation technique (tDCS) can reduce depression in people who have had a stroke. About 120 adults aged 18-65 with moderate to severe depression after a stroke will be randomly assigne…

This study looks at whether adding a Chinese herbal formula called Liqin Zhike to standard asthma inhalers (ICS/LABA) can improve outcomes for people with cough variant asthma. About 236 adults newly diagnosed with this condition will take part. The main goal is to see if the com…

This study looks at whether the drug amisulpride can help prevent nausea and vomiting after gynecological laparoscopic surgery. About 526 women will take part. The main goal is to see how many have no vomiting and don't need extra anti-nausea medicine within 24 hours after surger…

This study tests whether a gentle electric current applied to acupuncture points can improve memory and thinking in people who have cognitive problems after a stroke. About 110 adults aged 35-80 will be randomly assigned to receive either real electroacupuncture or a sham version…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce anxiety in people having major abdominal surgery. Over half of these patients experience anxiety, which can slow recovery. The trial will involve 282 adults who will receive e…

This study looks at whether early treatment with hyperbaric oxygen (breathing pure oxygen in a pressurized chamber) can improve pain, swelling, and function in people with a recent ankle sprain. About 208 adults with a sprain within the last 72 hours will be randomly assigned to …

This study tests whether adding a gentle nerve stimulation device (taVNS) to a standard neck injection can better relieve pain from pinched nerves in the neck. About 80 adults with cervical radiculopathy will be randomly assigned to get either the real device or a sham device alo…

This study tests whether papaverine, a drug that relaxes blood vessels, can relieve nerve pain and numbness caused by chemotherapy that hasn't responded to standard treatments. About 43 adults with persistent symptoms will receive papaverine infusions weekly for up to three weeks…

This study looks at whether CGRP-targeted medications can help people with vestibular migraine, a condition where dizziness and vertigo are more common than headaches. Researchers will enroll 2,000 Chinese adults aged 18 to 75 to see if these drugs reduce dizziness severity and f…

This study compares two methods to keep the surgical area clear during ankle arthroscopy: using a dilute epinephrine solution versus a traditional tourniquet. About 88 people with chronic ankle instability or ligament injuries will take part. The goal is to see if the epinephrine…

This study looks at 1,280 adults aged 18 to 75 who had colon polyps removed. Researchers want to create a tool that predicts if polyps will come back. They will use past medical records and follow new patients over time, collecting lifestyle details and blood samples. The goal is…

This study surveys over 13,000 healthcare providers in emergency rooms across China to understand how well they know and follow guidelines for pain relief and sedation. The goal is to identify gaps in knowledge and practice, and to improve patient care in critical situations. Par…

This study aims to create a biobank by collecting blood, tissue, bile, and other samples from 300 adults with liver, bile duct, or pancreatic tumors, as well as from people with benign conditions and healthy volunteers. No experimental treatments or extra procedures are involved—…

This study tests a computer system called LingBao that helps doctors decide the best treatment for people having a stroke. About 3,000 adults who arrive at the hospital within 24 hours of stroke symptoms will take part across 20 stroke centers. The AI reviews patient data and sug…

This study looks at how a new pain medicine called Anrikefon works in people aged 65 and older after laparoscopic (keyhole) belly surgery. Thirty participants will receive the drug at set times and have their blood tested to measure drug levels. The goal is to understand how the …

This study looks at 40 men with a narrowed urethra who need surgery. It compares two ways of removing hair before the operation to see which one lowers bacteria on the skin more effectively. The goal is to find a better method to prevent infections after surgery.

This study uses a realistic simulator to see if a special 3D lung display (called a 'Digital Twin') helps doctors feel less stressed and find breathing problems faster compared to standard monitors. About 34 ICU doctors will manage four different emergency scenarios, and their me…

This study aims to see if a special eye scan (OCTA) analyzed by artificial intelligence can predict how well patients with a vision-threatening condition called myopic choroidal neovascularization (mCNV) will respond to standard anti-VEGF injections. Researchers will follow 110 p…

This study aims to create a better way to predict serious heart problems, like another heart attack or death, in people who have already had a heart attack. Researchers will use artificial intelligence to analyze a wide range of medical data from 1,544 adults who have had a heart…

This study aims to build an AI tool that analyzes standard tissue images from liver cancer patients after surgery. The goal is to predict who will benefit from additional treatments like chemotherapy or targeted drugs. Researchers will use data from 1,000 patients across multiple…

This study aims to create an artificial intelligence (AI) system that can combine medical images (like CT or MRI scans) with patient records to help doctors diagnose liver, gallbladder, and pancreas diseases more accurately. The researchers will use data from 2,000 adult patients…

This study compares two different ventilators (TV80 and HAMILTON-T1) to see which one keeps oxygen levels more stable when moving patients who are on breathing machines. About 98 adults who need a ventilator and are being transported within or between hospitals will be randomly a…