Second Affiliated Hospital, School Of Medicine, Zhejiang University

This study is testing if adding the blood thinner rivaroxaban to standard medications improves blood flow in the heart's arteries after a procedure to open a blockage from a severe heart attack. Researchers will compare the new three-drug combination to the standard two-drug ther…

This study compares two minimally invasive endoscopic procedures for treating small intestinal narrowing (strictures) in people with Crohn's disease. Researchers want to see which method—balloon dilation or a small incision technique—is more effective at keeping the passage open …

This study aims to see if a light-based therapy called ALA-PDT works as well as standard surgery (LEEP) for treating high-grade cervical cell changes (HSIL/CIN2). It will involve 560 women aged 25-60. The goal is to find a less invasive treatment option that may better preserve c…

This early study is testing a new cell therapy for adults with severe epilepsy that doesn't respond to medications. Doctors will inject specially grown brain cells directly into the brain during surgery, and patients will take immune-suppressing drugs before and after. The main g…

This study is testing whether a combination of three drugs—benmelstobart, anlotinib, and cyclophosphamide—can help control recurrent ovarian, fallopian tube, or primary peritoneal cancer. It aims to see if this treatment can delay cancer progression and is safe for patients. The …

This study is testing whether adding a new immunotherapy drug (ipilimumab N01) to an existing combination treatment is safe and effective for people with advanced liver cancer. Researchers will compare three groups to see if the timing of the new drug matters. The goal is to cont…

This study is testing whether a drug called leucogen can prevent a serious side effect of breast cancer treatment. Researchers want to see if leucogen reduces severe drops in white blood cells (neutropenia) in early-stage breast cancer patients taking ribociclib with hormone ther…

This study is testing a capsule called icaritin as an additional treatment after surgery for liver cancer. It aims to see if taking this pill can help prevent the cancer from coming back in patients who are at high risk of recurrence. The trial will enroll 25 participants and clo…

This study is testing whether a light-based treatment can clear high-risk HPV infection and reverse early abnormal cervical cell changes. It will compare the treatment to simply watching and waiting in 225 women aged 20-60 who have HPV types 16 or 18. The goal is to see if the tr…

This study is testing whether the antibody drug lecanemab helps control Alzheimer's disease progression better than standard treatments. Researchers will follow 120 patients with early Alzheimer's or mild cognitive impairment to see who benefits most from continued treatment. Usi…

This study aims to find out which of two common fertility treatments works better for couples who can't get pregnant but have no clear medical reason why. It will follow 848 couples in China undergoing their first treatment cycle, randomly assigning them to either standard IVF or…

This study compares two different injections, bleomycin and pingyangmycin, for treating plantar warts (warts on the soles of feet). Each participant will receive both treatments—one injection type on some warts and the other type on their remaining warts—and be followed for up to…

This early-stage trial is testing a new cell therapy for people with severe, end-stage idiopathic pulmonary fibrosis (IPF), a fatal lung-scarring disease. Doctors will give patients specially engineered immune cells designed to find and calm the scar tissue in the lungs. The main…

This early-stage study is testing a new cell therapy called CNK-UT009 in patients with severe inflammatory bowel disease (Crohn's or colitis) who haven't responded to multiple other treatments. The main goal is to check if the treatment is safe and determine the right dose. Resea…

This study is testing whether adding a new immunotherapy drug called envafolimab to standard chemotherapy works better for advanced soft tissue sarcoma. The trial will enroll 15 adults who have not had prior treatment for their cancer. Researchers hope this combination will bette…

This study is testing whether the drug everolimus can help control advanced colorectal cancer that has a specific genetic change called CDK12 deficiency and has stopped responding to standard treatments. The trial will first find the safest dose, then see if the drug shrinks tumo…

This study aims to understand how a new pain medication called Anrikefon is processed in the bodies of older adults after abdominal surgery. It will enroll 30 participants aged 65 and older to measure the drug's levels in their blood. The goal is to gather information to help det…

This study aims to see if eating foods high in resistant starch can help slow down memory and thinking problems in adults who are at high genetic risk for cognitive decline and are overweight. 70 participants will be randomly assigned to eat either the special starch foods or reg…

This study aims to find the best way to manage the nerve inside a tooth when a healthy wisdom tooth is transplanted to replace a bad molar. Researchers will compare three different nerve care strategies in 360 participants to see which leads to the most successful, long-lasting t…

This study aims to see how well the drug mavacamten works for people with a specific form of hypertrophic cardiomyopathy (HCM), where the heart muscle is abnormally thick and causes a blockage in the middle or tip of the heart's main pumping chamber. It will involve 132 adult pat…

This study is testing a new three-drug combination given before surgery for locally advanced colorectal cancer. The goal is to see if adding an immunotherapy drug and a diabetes drug (sitagliptin) to standard chemotherapy can shrink tumors more effectively. The trial will first c…

This early-stage study is testing whether adding special tendon stem cells during surgery can help people with rotator cuff tears heal better. Researchers will give the cell therapy to about 107 patients during their standard shoulder repair surgery. The main goals are to first c…

This study is testing whether a new type of mouthwash called Amphion can help people with gum disease when used alongside standard dental cleaning treatments. The mouthwash works by forming a protective barrier in the mouth to prevent plaque from regrowing, potentially reducing i…

This study is testing if adding a traditional Chinese herbal formula called Liqin Zhike to standard asthma inhalers works better for a type of asthma that mainly causes a long-lasting cough. Researchers will compare two groups of 118 adults each over 14 months to see which treatm…

This study is testing whether an oral medication called ivarmacitinib can help control polymyalgia rheumatica (PMR) while reducing the need for steroid medications. The trial will involve 80 adults aged 50-75 with active PMR who will receive either the study drug or a placebo for…

This study is testing whether a new drug called Ivonescimab (AK112), when given with standard chemotherapy before surgery, can help people with a type of esophageal cancer. The goal is to shrink the tumor and kill any hidden cancer cells to improve the chance of a successful surg…

This study is testing a new AI computer system called LingBao, designed to help doctors quickly decide the best treatment for patients having a stroke caused by a blood clot. At 20 major stroke centers, half will use the AI tool alongside standard care, while the other half will …

This study is testing if adding a specific probiotic (Lactobacillus johnsonii) to standard chemotherapy and immunotherapy helps people with certain advanced cancers. It will enroll 156 adults with advanced lung, breast, or stomach cancer that has progressed after prior immunother…

This study is testing a new combination of three existing drugs to see if it can help control advanced soft tissue sarcoma that has come back or stopped responding to other treatments. It will involve 24 patients who have already tried at least one prior therapy. The main goals a…

This early-stage study is testing a new type of cell therapy for adults with glioblastoma that has come back after treatment. Doctors will collect a patient's own immune cells, modify them in a lab to better target the cancer, and then infuse them back. The main goals are to see …

This early-stage study is testing a new cell therapy for people who have a severe heart attack that leads to cardiogenic shock, a dangerous condition where the heart can't pump enough blood. Researchers are giving patients specially engineered immune cells from healthy donors, de…

This study is testing if a device called Adacolumn can help control dangerous brain swelling that can happen after a major stroke. It will involve 10 patients who have already had a procedure to remove the stroke-causing clot. Half will get the device treatment, which filters cer…

This study aims to determine whether traditional open surgery or minimally invasive laparoscopic surgery leads to better long-term outcomes for colon cancer patients who have significant abdominal fat. Researchers will follow 664 patients for five years after surgery to see which…

This study is testing if a drug called surufatinib can help prevent cancer from returning after surgery in patients with high-risk neuroendocrine tumors. It will enroll about 35 patients whose cancer is classified as Stage III or has other high-risk features. The main goal is to …

This study aims to see how well a newer class of migraine drugs (CGRP-targeted medications) works for treating vestibular migraine, a condition that causes severe dizziness and vertigo. It will follow 2,000 Chinese patients in a real-world setting to measure if these drugs can re…

This study aims to determine if a smaller, more conservative surgery is as effective as complete thyroid removal for treating certain low-risk thyroid cancers located in the middle of the gland. It will involve 520 adults with small, unspread tumors and directly compare cancer re…

This study is testing a new artificial intelligence (AI) system designed to help doctors diagnose diseases of the liver, gallbladder, and pancreas. The AI will analyze patients' medical scans (like CT or MRI) along with their health records to see if it can identify diseases and …

This study aims to develop an artificial intelligence (AI) tool that can detect breast cancer early using standard MRI scans without contrast dye. It will enroll 30,000 women in China to test if this safer, more accessible method is as accurate as current techniques. The goal is …

This study is developing an artificial intelligence (AI) tool to help doctors choose the best treatment for patients after liver cancer surgery. The AI analyzes standard digital images of a patient's tumor tissue to predict whether they are likely to benefit from specific follow-…

This study aims to develop and test an artificial intelligence (AI) tool designed to predict a patient's risk of having another heart attack within six months. It will enroll 1,500 adults who have just had a heart attack and received a stent. The AI model will analyze a wide rang…

This study is testing a new AI-powered blood test to see how accurately it can determine the stage of breast cancer, specifically whether it has spread to lymph nodes. Researchers will collect blood samples from 269 people with breast cancer, some having surgery directly and othe…

This study aims to test a new artificial intelligence (AI) tool designed to screen for heart valve disease. It will analyze routine chest CT scans from 10,000 people to see if the AI can accurately identify those with moderate-to-severe valve problems. If the AI flags a potential…

This study is testing whether a gentle, non-invasive electrical stimulation device placed on the ear can help reduce anxiety in patients before and after major abdominal surgery. Researchers will compare the real device to a fake one in 282 patients to see if it lowers anxiety, i…

This study tests whether gentle electrical stimulation on the ear can help reduce pain and the need for strong painkillers after complex spine surgery. Researchers will enroll 98 patients having major spinal operations. Participants will be randomly assigned to receive either rea…

This study aims to see if a high-tech combination treatment can help ease depression that occurs after a stroke. Researchers will test whether using virtual reality mindfulness therapy together with a gentle, non-invasive brain stimulation technique works better than either treat…

This study compares two methods to help surgeons see better during ankle surgery. One group gets a special irrigation fluid containing epinephrine, while the other gets the standard tourniquet. Researchers will measure how clear the surgical view is and check patients' pain level…

This study aims to find which type of anesthesia helps patients recover most quickly after minimally invasive ankle surgery. Researchers will compare three different anesthesia techniques in 200 adults having elective ankle procedures. The main goal is to see which method gets pa…

This study is testing whether breathing pure oxygen in a pressurized chamber helps people with recent ankle sprains recover faster. It will compare this special oxygen treatment against breathing normal air to see which one better reduces pain and swelling and improves ankle func…

This study is testing whether electroacupuncture (a combination of acupuncture with mild electrical stimulation) can help improve thinking and memory in people who have cognitive problems after a stroke. About 110 participants will be randomly assigned to receive either real elec…

This study is testing a new, long-acting numbing medicine to see if it can better control pain after a specific brain surgery called microvascular decompression. Researchers will compare the new medicine, injected around the surgical cut, to standard pain care in 100 patients. Th…

This study aims to create a collection of tissue and blood samples from patients with liver, bile duct, and pancreatic cancers. Researchers will collect leftover samples from routine medical care without any additional procedures for participants. The collection will serve as a r…

This study aims to understand why recovery varies so much after common shoulder and knee surgeries for sports injuries. Researchers will follow 500 patients for two years after their routine surgery, tracking their pain, function, and recovery progress. The goal is to identify wh…

This study aims to create a better tool to predict which heart attack survivors are at highest risk for having another serious heart problem or dying from heart disease. Researchers will use a wide range of patient data to build an AI-powered prediction model. The goal is to help…

This study aims to understand how emergency room staff in China manage patient pain and sedation. It will survey thousands of healthcare workers and observe patient care to see if standard guidelines are being followed. The goal is to identify gaps in knowledge and practice to im…

This study aims to compare a new emergency transport ventilator to a standard one to see if it keeps oxygen levels just as stable when moving patients who are on breathing machines. Researchers will enroll about 98 adults who need to be moved within or between hospitals while on …

This study aims to use artificial intelligence (AI) to analyze special eye scans (OCTA) from 110 patients. The goal is to find patterns that can predict how well standard eye injections work over two years for a condition called myopic choroidal neovascularization (mCNV), which c…

A Multicenter, Prospective, Randomized Controlled Trial to Evaluate the Efficacy and Safety of Bisphosphonates Combined with Vancomycin in the Treatment of Refractory Osteomyelitis