Antibiotic trial aims to stop COPD attacks by targeting hidden fungus

NCT ID NCT07665359

Not yet recruiting Disease control Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a 4-week course of the antibiotic TMP-SMX (Bactrim) can reduce the number of serious COPD flare-ups in people whose lungs carry Pneumocystis jirovecii, a common fungus. Researchers will compare the antibiotic to a placebo in 630 adults with advanced COPD who have had at least one flare-up in the past year. Participants will be followed for one year to track flare-ups and lung function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Trimethoprim-Sulfamethoxazole (TMP-SMX), also known as Bactrim or Sulfatrim
What this could lead to: If it works, this could point toward a new way to prevent COPD flare-ups by treating a hidden infection in the lungs.
What could go wrong: This is an early-stage trial with no phase assigned, so results are uncertain. The antibiotic may not clear the fungus or reduce flare-ups, and could cause side effects like allergic reactions or antibiotic resistance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Contacts and locations

Locations

Affiliated Hospital of Jiaxing University

Jiaxing, Zhejiang, China
First Affiliated Hospital of Wenzhou Medical University

Wenzhou, Zhejiang, China
First Affiliated Hospital of Zhejiang University

Hangzhou, Zhejiang, China
Huzhou Central Hospital

Huzhou, Zhejiang, China
Lishui hospital of Zhejiang University

Lishui, Zhejiang, China
Red Cross Hospital, Hangzhou, China

Hangzhou, Zhejiang, China
Second Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, China
Shanghai Pulmonary Hospital, Shanghai, China

Shanghai, Shanghai Municipality, China
Shanghai Tongji Hospital, Tongji University School of Medicine

Shanghai, Shanghai Municipality, China
Shaoxing People's Hospital

Shaoxing, Zhejiang, China
Sir Run Run Shaw Hospital

Hangzhou, Zhejiang, China
Taizhou Hospital

Taizhou, Zhejiang, China
Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University

Taizhou, Zhejiang, China
The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China
The Sixth Affiliated Hospital of Wenzhou Medical University

Lishui, Zhejiang, China
Tongji Hospital

Wuhan, Hubei, China
West China Hospital

Chengdu, Sichuan, China
Zhejiang Hospital

Hangzhou, Zhejiang, China
Zhejiang Quhua Hospital

Quzhou, Zhejiang, China
Zhejiang Rongjun Hospital

Jiaxing, Zhejiang, China

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