CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

This study is testing whether a drug called omalizumab, given as injections for 12 months, can reduce the frequency of serious symptom flare-ups in people with COPD who are also allergic to common indoor allergens like pet dander or dust mites. It will involve about 334 adults ov…

This study will follow 350 adults with uncontrolled COPD for two years to see how well the drug dupilumab works in real-world settings. Researchers will track if the drug improves patients' quality of life, reduces breathing flare-ups, and is safe for long-term use. The study is …

This study is testing whether adding stem cell injections to standard medication helps people with severe COPD. Twenty patients already on triple-inhaler therapy will receive either umbilical cord stem cells or a placebo. Researchers will monitor lung function, walking ability, a…

This is the first human study of an experimental drug called BBT002 for chronic obstructive pulmonary disease (COPD). The main goal is to check if the drug is safe and how it behaves in the body, first in healthy volunteers and then in people with COPD. Researchers will give incr…

This study is testing two different approaches to sedation for people with severe COPD who need help breathing from a ventilator. Researchers want to see if using no sedation at all or briefly stopping sedation each day helps patients spend fewer days on the breathing machine. Th…

This study aims to help people with COPD and asthma stick to their inhaled medication plans. Researchers will test a new mobile app and training program designed to teach both patients and their healthcare providers the correct way to use inhalers. The goal is to improve treatmen…

This study is testing whether a monthly injection called tezepelumab can help control Chronic Obstructive Pulmonary Disease (COPD). It aims to reduce the frequency of serious breathing flare-ups and improve lung function and quality of life for adults with moderate to very severe…

This study is testing a new oral medication, AZD6793, to see if it can reduce the frequency and severity of symptom flare-ups (exacerbations) in people with moderate to very severe COPD. About 1160 participants will be randomly assigned to receive one of three different doses of …

This large study aims to find the best steroid medicine for treating sudden, serious flare-ups of COPD (chronic obstructive pulmonary disease). It will compare two commonly used steroids, hydrocortisone and prednisolone, in 2,000 adults over 40. The main goal is to see which one …

This large study is testing whether a new medication called astegolimab can help people with COPD who experience frequent breathing attacks. About 1,290 participants who are former or current smokers with a history of these flare-ups will receive either the drug or a placebo for …

This early-stage study is testing a new treatment for moderate-to-severe COPD, a serious lung disease that makes it hard to breathe. Researchers are giving patients infusions of special stem cells taken from fetal tissue, hoping these cells can repair damaged lung structures and …

This study is testing if a monthly injection called tezepelumab can help adults with moderate to very severe COPD. The main goal is to see if it reduces the number of times a person's breathing suddenly gets much worse (called an exacerbation or flare-up). About 990 participants …

This study is testing if a wearable device can help people with COPD by spotting early warning signs of a serious symptom flare-up (called an exacerbation). Researchers will give 50 participants a device to wear at home for three months to track things like heart rate and oxygen …

This large study is testing whether using special air cleaners in the home can help people with COPD. It will involve 770 former smokers with COPD across multiple medical centers. Participants will be randomly assigned to receive either real air cleaners or look-alike devices tha…

This study is testing an investigational medicine called 9MW1911 to see if it can help people with COPD. The main goal is to see if it reduces the number of serious breathing flare-ups over one year. About 360 participants will be randomly assigned to receive either the study med…

This study is testing if a wrist-worn device that automatically counts coughs can give an early warning for serious flare-ups in people with COPD. The goal is to see if a change in cough frequency can predict a flare-up before it becomes severe, potentially allowing for earlier t…

This study is testing a wearable device called WearME to see if it can accurately monitor lung function and breathing in people with COPD. It will compare the device's measurements to standard hospital equipment used during a single 145-minute session. The goal is to see if this …

This study is testing whether a special breathing device can help people with COPD feel less short of breath after physical activity. About 33 adults with moderate to severe COPD will use the device at home for one week and then a dummy device for another week, with walking tests…

This study is testing if a structured walking and light resistance exercise program can help people with COPD feel better. Over three months, one group will follow an exercise plan that gradually increases in time, while another group just tracks their activity. Researchers will …

This study is testing whether inhaling nitric oxide gas for one week can help people with moderate-to-severe COPD exercise more easily and feel less breathless. Researchers will measure how far participants can walk, how hard they feel they're working, and their breathing efficie…

This study is testing a new 8-week program that combines mindfulness training with personalized exercise coaching for people with chronic obstructive pulmonary disease (COPD). The goal is to see if this hybrid approach can help reduce stress, improve breathing, and increase physi…

This study aims to better understand people with chronic obstructive pulmonary disease (COPD) in Russia. Researchers will observe 2000 patients with moderate-to-severe COPD who experience frequent symptom flare-ups. The goal is to describe who these patients are and see what trea…

This study aims to observe how COPD patients fare while taking the medication dupilumab in real-world medical settings. Researchers will follow about 500 participants in France for three years to collect information about their health, symptoms, and any side effects. The study do…

This study aims to learn more about a specific type of high blood pressure in the lungs (pulmonary hypertension) that can occur in people with COPD. Researchers will look back at the existing medical records of 1,000 patients who already had a specific heart test. The goal is to …

This study aims to collect blood, urine, and airway samples from both healthy people and people with lung diseases like COPD and pulmonary fibrosis. Researchers will compare the samples to understand what causes these diseases and how they develop. The goal is to gather basic inf…

This study aims to better understand the lives of people in Greece who have both Chronic Obstructive Pulmonary Disease (COPD) and a heart condition. Researchers will follow 900 participants for two years to track their health events, quality of life, and how they use healthcare s…

This study aims to understand why people with chronic lung diseases like asthma and COPD feel their breathing difficulty so differently. Researchers will observe about 800 patients and 150 healthy volunteers, using questionnaires, lung tests, blood work, and brain scans to look f…

This study aims to better understand how Chronic Obstructive Pulmonary Disease (COPD) interacts with other common health problems like heart disease and diabetes. It will follow 10,000 patients, using wearable devices and traditional Chinese medicine assessments alongside standar…

This study aims to see if it's possible to use brain scans to understand how people with serious illnesses like cancer, COPD, or heart failure experience chronic breathlessness. Researchers will use functional MRI scans and immersive virtual reality with 16 participants to see if…

This study aims to understand how taking many different medications affects the health of older adults living with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will follow 2,000 participants aged 65 and older for two years, asking them to co…

This study aims to understand how two different types of breathing muscle training affect oxygen levels in the muscles of people with COPD. Twenty participants with moderate to severe COPD will try both a traditional and a newer 'functional' training method on separate days, foll…

This study aims to understand how different types of support from family and friends—like emotional encouragement or practical help—affect a person's ability to manage their COPD symptoms day-to-day. Researchers will survey and interview about 111 adults with COPD to learn what s…

This study aims to gather detailed information about people with Chronic Obstructive Pulmonary Disease (COPD) in Moscow who experience frequent symptom flare-ups. Researchers will observe 500 patients over time to understand their health characteristics, current treatments, and r…

This Canadian study aims to understand how mucus buildup affects people with asthma, COPD, and chronic cough. Researchers will use CT scans and other tests to measure mucus in 240 adults and 50 children over two years. The goal is to find better ways to identify and treat mucus p…