CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

This Phase 3 study tests whether tezepelumab, a biologic drug, can reduce moderate to severe COPD flare-ups in adults aged 40-80. About 990 participants will receive either tezepelumab or a placebo as a shot under the skin. The main goal is to see if the drug lowers the number of…

This Phase 3 trial tests whether tezepelumab, a biologic drug given as a shot, can reduce the number of moderate to severe COPD flare-ups in adults aged 40 to 80. About 990 participants with moderate to very severe COPD will receive either tezepelumab or a placebo for up to 76 we…

This study tests an experimental tablet called AZD6793 in adults with moderate to very severe COPD. About 987 participants will take one of two doses of the drug or a placebo for 24 weeks. The goal is to see if the drug can reduce the number of serious flare-ups (exacerbations) c…

This study looks at whether treating a common stomach infection (H. pylori) can improve symptoms and lung function in people with COPD. Researchers will give standard antibiotic therapy to 54 H. pylori-positive COPD patients and then measure changes in their breathing tests and s…

This early-stage trial is testing whether infusions of clonal fetal mesenchymal stem cells (cfMSCs) are safe and can help control severe symptoms in people with moderate to severe COPD. About 30 adults aged 40-80 who have not responded well to standard treatments will receive the…

This early-phase trial tests REGEND007, a stem cell therapy made from airway cells, in 12 people with COPD. The cells are given by IV infusion in increasing doses to see if they are safe and can help repair lung damage. The study is still recruiting and focuses on safety first.

This study compares two steroids, hydrocortisone and prednisolone, in 2000 adults over 40 with COPD flare-ups. The goal is to see which one reduces hospital readmissions and deaths within 30 days. Participants are randomly assigned to one of the two treatments.

This study tests if umbilical cord stem cells can improve lung function and quality of life in people with severe COPD. All 20 participants already receive standard triple-inhaler therapy. They will get stem cells or a placebo intravenously and be followed for 12 months. The goal…

This study tests if omalizumab (Xolair), an allergy drug, can reduce serious flare-ups in people with COPD who also have allergies. About 334 participants will receive injections of the drug or a placebo for 12 months. The goal is to see if the drug lowers the number of COPD exac…

This study follows 350 adults with uncontrolled COPD who are starting dupilumab, a medication that reduces lung inflammation. Researchers will track changes in quality of life and breathing symptoms over two years using simple questionnaires. The goal is to see how well the drug …

This phase II trial is testing an experimental drug called 9MW1911 in 360 adults with moderate-to-severe COPD who have had at least two flare-ups in the past year. Participants receive either the drug or a placebo every 28 days for a year. The main goal is to see if the drug redu…

This study tests whether placing two high-efficiency air cleaners in the homes of 770 people with COPD can reduce flare-ups and improve quality of life over a year. Participants receive either active cleaners that remove particles and gases, or sham cleaners that look and sound t…

This study looks at two ways to manage sedation in COPD patients who need a breathing machine (ventilator). One group gets no sedation at all, while the other has their sedation paused every day. The goal is to see which approach helps patients spend more days off the ventilator …

This study tests whether a single 20-minute session with a medical device called Simeox can reduce the amount of air trapped in the lungs of people with severe COPD. The device applies gentle suction during exhalation to help move air out. Researchers will measure lung function b…

This study tests a new program called Mindful-Breath for people with chronic obstructive pulmonary disease (COPD). The program combines mindfulness, breathing exercises, and lifestyle coaching through group sessions and chat support. Researchers want to see if it is feasible and …

This study tests whether a device that uses gentle pressure changes to clear mucus and trapped air from the lungs can reduce shortness of breath after walking in people with COPD. About 33 adults who have completed pulmonary rehab will use the active device or a placebo at home f…

This study aims to bring pulmonary rehabilitation—a proven treatment for COPD—to people living in rural areas who currently have no access to it. Researchers will test whether a home-based program can improve breathing, fatigue, and emotional well-being. About 306 adults aged 40 …

This study looks at whether the Vivifrail exercise program can improve physical function and quality of life in older adults with COPD who are also frail. Researchers will enroll 80 participants aged 60 and older, giving half the exercise program and half standard care. The goal …

This study tests a special arm exercise program for people with moderate to severe COPD. Participants will do light arm exercises while wearing cuffs that slightly restrict blood flow. The goal is to see if this approach can improve arm strength, daily activities, and quality of …

This study is testing whether inhaling nitric oxide gas can improve exercise tolerance in people with moderate-to-severe COPD. Sixteen participants will use a special device to breathe the gas for one week. Researchers will measure changes in oxygen use and breathing efficiency d…

This early-stage study tests a new drug called BBT002 in healthy people and those with COPD to see if it is safe and tolerable. Researchers will also look for early signs that it might ease breathing problems. About 68 participants will receive either the drug or a placebo, with …

This study tests whether a 12-week program of walking and elastic band exercises can improve anxiety, depression, breathlessness, sleep, and quality of life in people with COPD. 68 participants will either do the exercise program plus standard care or just wear a smart bracelet t…

This study looks at whether giving extra oxygen during a 6-minute walk test helps people with chronic lung disease walk farther and feel better. About 114 adults with conditions like COPD or interstitial lung disease will do two walking tests—one with their usual oxygen and one w…

This study aims to understand why breathlessness varies among people with different lung diseases like COPD, asthma, and ILD. Researchers will measure lung function, exercise ability, and breathing patterns in 75 participants (50 with lung disease and 25 healthy controls). The go…

This study looks at whether people with type 2 diabetes, COPD, or heart disease who join a health program in Halsnaes Municipality improve their physical function and well-being. About 194 adults will be tracked before and after the program using tests and questionnaires. The goa…

This study will collect information from about 500 adults in Moscow who have moderate to very severe COPD and have had frequent flare-ups. Researchers will look at their medical history, current treatments, and overall health to better understand the disease and how it is managed…

This study tests a digital lifestyle platform designed to support patients after they leave inpatient rehabilitation. It includes people with COPD, heart problems, fractures, or minor stroke. Participants use the platform for six months, receiving personalized recommendations and…

This study looks at 100 COPD patients on breathing machines to see if a new ultrasound-based method (D-RSBI) is better than the standard method (RSBI) at predicting when they can safely breathe on their own. Researchers will measure both methods during a breathing trial and check…

This study looks at whether a new way of organizing hospital care, called an Acute Medical Unit, can help older adults with sudden illnesses like infections or COPD get better faster and spend fewer days in the hospital. Researchers will compare 220 patients who receive this new …

This study follows about 500 adults with COPD who are already taking dupilumab as part of their regular care. Researchers will collect health information over 3 years to see how patients are doing and check for any side effects. The goal is to learn more about the real-world effe…

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study looks at how different frequencies of whole body vibration affect lung function, breathing muscles, arm strength, flexibility, and quality of life in healthy adults and people with moderate to severe COPD. About 102 participants will try three vibration frequencies in …

This study compares exercise ability, muscle strength, blood vessel stiffness, and quality of life among three groups: people with COPD, those with a less-known condition called PRISm (Preserved Ratio Impaired Spirometry), and healthy individuals. Researchers will measure these f…

This study looks at how the immune system influences disease control in people with inflammatory airway diseases like asthma, COPD, and bronchiectasis. Researchers will analyze blood and sputum samples from 200 participants to find links between immune cell patterns and disease s…

This study is observing 10,000 adults aged 40-80 with COPD to learn how combining Western medicine with Traditional Chinese Medicine (like tongue and pulse checks) and wearable devices can help predict and manage other health problems that often come with COPD. The goal is to cre…

This observational study is investigating how patients with chronic airway diseases like COPD and asthma perceive breathing difficulty. Researchers will assess about 950 participants (800 patients and 150 healthy volunteers) using questionnaires, lung function tests, blood sample…

This study will give 50 COPD patients a wearable device to track their heart rate, breathing, oxygen levels, and activity for three months after a severe flare-up. The goal is to understand how symptoms change at home and build a computer model that could one day warn patients an…

This study explores how emotional, practical, and social support affects the ability of people with COPD to manage their own health. Researchers will survey 111 adults aged 40 and older with COPD, and interview 20 of them in depth. The goal is to understand what helps or hinders …

This study looks back at medical records of 1,000 people with COPD who also had a special heart test called right heart catheterization. Researchers want to understand a specific lung-heart problem called pulmonary hypertension. By analyzing this data, they hope to better identif…

This study uses brain scans (fMRI) to see if people with cancer, COPD, or heart failure have different brain activity patterns when they feel breathless. It also tests whether immersive virtual reality can help ease that breathlessness. Only 16 participants are being recruited to…

This observational study will use CT scans to measure mucus plugging in the airways of people with asthma, COPD, or chronic cough, and compare them to healthy volunteers. Researchers hope to understand how mucus changes over time and find biomarkers that could guide treatment. Th…

This study tests whether a wrist-worn device that counts coughs can predict serious COPD flare-ups early. Fifty adults with COPD will wear the Hyfe monitor, which tracks cough frequency without recording audio. Participants also answer weekly symptom questions. The goal is to see…

This study collects blood, airway, and urine samples from 2,000 healthy volunteers and people with lung diseases like COPD and pulmonary fibrosis. Researchers will compare samples to establish normal ranges and learn how genes change in lung disease. The goal is to better underst…

This study aims to understand and improve how patients with COPD and asthma use their inhalers. Researchers will assess patients' inhaler technique and provide education, while also evaluating healthcare professionals' knowledge. The goal is to boost adherence to treatment and re…

This study looks at how taking multiple medications (polypharmacy) affects the health of elderly people with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will survey 2000 patients aged 65 and older over two years to understand their medicati…

This study is observing 900 adults in Greece who have both chronic obstructive pulmonary disease (COPD) and at least one heart condition. Researchers will track their health for two years, recording lung flare-ups, heart complications, hospital visits, and quality of life. The go…

This study is testing a wearable system called WearME to see if it can accurately measure lung function and breathing in people with COPD. Researchers will compare the device's readings to standard hospital tests like spirometry. The goal is to find a simpler way for patients to …