CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

This phase 2 trial is testing whether an experimental drug called PRA-216 can safely reduce airway inflammation in people with moderate to severe COPD who have a specific type of inflammation (type 2). Participants will receive either PRA-216 or a placebo, and researchers will mo…

This study tests an inhaled drug called KIT2014 in 36 adults with moderate to severe COPD. Participants will receive either the drug or a placebo daily for 7 days. The main goal is to check safety and how the body handles the drug, with a first look at whether it might help breat…

This trial investigates a surgical procedure to divide the fissure between lung lobes in people with COPD and emphysema who did not improve after endobronchial valve treatment. The goal is to see if the surgery is safe and feasible, potentially leading to better lung collapse and…

This study tests whether a 4-week course of the antibiotic TMP-SMX (Bactrim) can reduce the number of serious COPD flare-ups in people whose lungs carry Pneumocystis jirovecii, a common fungus. Researchers will compare the antibiotic to a placebo in 630 adults with advanced COPD …

This trial investigates whether the sequence of endurance and strength exercises during pulmonary rehabilitation affects muscle strength in people with moderate to severe COPD. Participants are randomly assigned to do either strength training before endurance work or the reverse.…

This study tests whether adding dupilumab to standard COPD treatment can prevent another flare-up or hospital stay within 90 days. About 754 adults who were recently hospitalized for a COPD exacerbation will receive either dupilumab or a placebo. The goal is to see if the drug re…

This study will follow 600 adults in Korea who have been prescribed Breztri for COPD, a long-term lung disease. Researchers want to see how safe the drug is in everyday use and whether it works as expected. Participants will take Breztri as their doctor prescribes, and the study …

This study tests whether Guben Kechuan Granules, a traditional Chinese medicine, can improve lung function and quality of life in people with COPD who are recovering from a sudden worsening of symptoms. 126 patients will receive either the granules or a placebo on top of standard…

This Phase 3 trial tests an experimental injection called JKN2401 in 888 people with moderate-to-severe COPD. The goal is to see if it can safely reduce the number of serious flare-ups compared to a placebo. Participants will receive injections every four weeks and be monitored f…

This study is testing whether a simple, 1-minute heart recording (ECG) analyzed by a computer can help detect pulmonary embolism, a serious blood clot in the lungs. Researchers will enroll 500 adults who need to be checked for this condition. The goal is to see if this quick, non…

This study tests whether teaching COPD patients structured energy conservation techniques—like planning activities, using proper body mechanics, and breathing exercises—can improve their ability to do daily tasks, reduce fatigue, and boost exercise capacity. Seventy patients with…

This study tests whether several sessions of medical hypnosis can improve quality of life for people with COPD who still have severe shortness of breath despite standard treatment. About 154 adults with advanced COPD will be randomly assigned to either five hypnosis sessions or f…

This study looks at whether a structured program led by a physiotherapist can help people with COPD use their inhalers better. Many patients make mistakes that keep the medicine from reaching the lungs, making symptoms worse. Over 12 months, 116 participants will either get the p…

This study tests whether different breathing patterns (pursed-lip breathing with specific inhale/exhale ratios) can improve breathing in people with stable COPD. About 122 participants aged 40 and older will be assigned to one of three breathing ratios or standard care. Researche…

This early-stage study looks at whether metformin, a drug used for diabetes, is safe and tolerable for older adults (65+) with COPD who do not have diabetes. Researchers will also check if metformin changes blood markers linked to aging. The goal is to see if this approach is fea…

This study looks at whether a special training method called Pecha Kucha can help people with COPD who use a breathing machine at home. The training aims to increase patients' confidence in managing their symptoms, reduce how much symptoms bother them, and make daily activities e…

This study looks at whether a special breathing exercise (threshold inspiratory muscle training) can make the diaphragm thicker and move better in people with stable COPD. Fifteen participants aged 40-59 with moderate COPD will do the training. The goal is to see if this exercise…

This pilot study tests whether a pharmacist-led medication management program can improve safety and reduce shortness of breath in adults with COPD who also have other health conditions. About 92 participants will receive inhaler training and medication advice. The study focuses …

This study looks at whether special 'active' sports shoes can help people with severe COPD walk farther during a 6-minute walk test. About 75 adults with advanced COPD will try both the special shoes and their usual shoes, and researchers will compare how far they walk and how br…

This study looks at why some adults with chronic obstructive pulmonary disease (COPD) accept or decline a home-based pulmonary telerehabilitation program. By comparing the characteristics of those who agreed to participate with those who did not, researchers hope to identify barr…

This study looks at how nasal high-flow therapy—a device that delivers warm, moist air through small nasal tubes—affects the airways of people with severe chronic obstructive pulmonary disease (COPD). Researchers will measure airway resistance and other lung mechanics using a non…

This trial explores whether a training program for general practitioners can improve how primary care clinics deliver palliative care to adults with advanced cancer, COPD, heart failure, or kidney disease. One family health unit will use the new approach—a 30-hour e-learning cour…

This study tracks people over 40 hospitalized for a COPD flare-up to see how many have a type called eosinophilic COPD, marked by higher levels of certain white blood cells. Researchers will compare hospital stay length and need for breathing support between those with and withou…

This study is testing whether an integrated precision medicine platform can improve how doctors diagnose and manage chronic inflammatory lung diseases like COPD and idiopathic pulmonary fibrosis. Researchers will collect blood and saliva samples for biomarker analysis, monitor in…

This trial evaluates an active case-finding strategy to detect pulmonary tuberculosis (TB) among people with chronic obstructive pulmonary disease (COPD) in primary care clinics in Henan, China. The strategy uses computer-aided diagnosis and a rapid TB test during routine COPD vi…

This study looks at whether standard blood tests can help doctors predict the outcome of a sudden worsening of COPD, known as an acute exacerbation. Researchers will examine red blood cell and platelet measurements from routine blood work in 50 hospitalized adults. The goal is to…

This study will expose 24 healthy adults to different levels of wildfire smoke in a safe, controlled room to see how it affects their lungs and brain. Researchers want to understand why some people may be more vulnerable to long-term lung diseases like asthma, COPD, and lung canc…

This study tests a wearable patch called WearME-Pro that tracks lung function in people with COPD during daily life. Over 10 months, 82 adults will use the patch at home and compare its readings to a standard handheld spirometer. The goal is to see if the patch is accurate, easy …

This study will follow 120 adults with COPD who are starting triple inhaler therapy as part of their routine care. Researchers will measure a breath biomarker called FeNO at the start to see if it predicts future flare-ups or lung function decline. The goal is to better understan…