CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

This study tests whether a 4-week course of the antibiotic TMP-SMX (Bactrim) can reduce the number of serious COPD flare-ups in people whose lungs carry Pneumocystis jirovecii, a common fungus. Researchers will compare the antibiotic to a placebo in 630 adults with advanced COPD …

This study tests an inhaled drug called KIT2014 in 36 adults with moderate to severe COPD. Participants will receive either the drug or a placebo daily for 7 days. The main goal is to check safety and how the body handles the drug, with a first look at whether it might help breat…

This trial investigates whether the sequence of endurance and strength exercises during pulmonary rehabilitation affects muscle strength in people with moderate to severe COPD. Participants are randomly assigned to do either strength training before endurance work or the reverse.…

This study tests whether adding dupilumab to standard COPD treatment can prevent another flare-up or hospital stay within 90 days. About 754 adults who were recently hospitalized for a COPD exacerbation will receive either dupilumab or a placebo. The goal is to see if the drug re…

This study will follow 600 adults in Korea who have been prescribed Breztri for COPD, a long-term lung disease. Researchers want to see how safe the drug is in everyday use and whether it works as expected. Participants will take Breztri as their doctor prescribes, and the study …

This study tests whether Guben Kechuan Granules, a traditional Chinese medicine, can improve lung function and quality of life in people with COPD who are recovering from a sudden worsening of symptoms. 126 patients will receive either the granules or a placebo on top of standard…

This Phase 3 trial tests an experimental injection called JKN2401 in 888 people with moderate-to-severe COPD. The goal is to see if it can safely reduce the number of serious flare-ups compared to a placebo. Participants will receive injections every four weeks and be monitored f…

This study will test a once-daily triple inhaler (Trelegy) in 60 adults with moderate-to-severe COPD. Participants will take the inhaler for 12 weeks (with an optional 48-week extension) and undergo special 129-Xenon MRI scans to see how well air moves through their lungs. The go…

This study is testing whether a simple, 1-minute heart recording (ECG) analyzed by a computer can help detect pulmonary embolism, a serious blood clot in the lungs. Researchers will enroll 500 adults who need to be checked for this condition. The goal is to see if this quick, non…

This study will test a handheld ultrasonic spirometer against a conventional hospital spirometer in 100 adults with chronic respiratory diseases like COPD or asthma. Each participant will use both devices to see if the portable one gives accurate and reliable results. If successf…

This study tests whether several sessions of medical hypnosis can improve quality of life for people with COPD who still have severe shortness of breath despite standard treatment. About 154 adults with advanced COPD will be randomly assigned to either five hypnosis sessions or f…

This study tests whether teaching COPD patients structured energy conservation techniques—like planning activities, using proper body mechanics, and breathing exercises—can improve their ability to do daily tasks, reduce fatigue, and boost exercise capacity. Seventy patients with…

This study looks at whether a structured program led by a physiotherapist can help people with COPD use their inhalers better. Many patients make mistakes that keep the medicine from reaching the lungs, making symptoms worse. Over 12 months, 116 participants will either get the p…

This study tests whether different breathing patterns (pursed-lip breathing with specific inhale/exhale ratios) can improve breathing in people with stable COPD. About 122 participants aged 40 and older will be assigned to one of three breathing ratios or standard care. Researche…

This early-stage study looks at whether metformin, a drug used for diabetes, is safe and tolerable for older adults (65+) with COPD who do not have diabetes. Researchers will also check if metformin changes blood markers linked to aging. The goal is to see if this approach is fea…

This study looks at whether a special training method called Pecha Kucha can help people with COPD who use a breathing machine at home. The training aims to increase patients' confidence in managing their symptoms, reduce how much symptoms bother them, and make daily activities e…

This study looks at whether a special breathing exercise (threshold inspiratory muscle training) can make the diaphragm thicker and move better in people with stable COPD. Fifteen participants aged 40-59 with moderate COPD will do the training. The goal is to see if this exercise…

This pilot study tests whether a pharmacist-led medication management program can improve safety and reduce shortness of breath in adults with COPD who also have other health conditions. About 92 participants will receive inhaler training and medication advice. The study focuses …

This study looks at whether special 'active' sports shoes can help people with severe COPD walk farther during a 6-minute walk test. About 75 adults with advanced COPD will try both the special shoes and their usual shoes, and researchers will compare how far they walk and how br…

This study will expose 24 healthy adults to different levels of wildfire smoke in a safe, controlled room to see how it affects their lungs and brain. Researchers want to understand why some people may be more vulnerable to long-term lung diseases like asthma, COPD, and lung canc…

This study tests a wearable patch called WearME-Pro that tracks lung function in people with COPD during daily life. Over 10 months, 82 adults will use the patch at home and compare its readings to a standard handheld spirometer. The goal is to see if the patch is accurate, easy …

This study will follow 120 adults with COPD who are starting triple inhaler therapy as part of their routine care. Researchers will measure a breath biomarker called FeNO at the start to see if it predicts future flare-ups or lung function decline. The goal is to better understan…