CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

This pilot study investigates whether an 8-week ketogenic diet—high in fat and very low in carbs—can improve lung function, reduce inflammation, and boost exercise capacity in men aged 40–75 with mild-to-moderate COPD. Participants are randomly assigned to either the ketogenic di…

This completed study followed 152 COPD patients who started using a triple-combination inhaler (BGF) as part of their routine care. Researchers measured changes in symptoms and quality of life after 12 and 24 weeks. The goal was to see if the inhaler helps patients feel better an…

This study tested a drug called tozorakimab in over 1,700 people with COPD who had a history of flare-ups. The goal was to see if it could safely reduce severe breathing attacks over the long term. Participants who completed earlier trials were given either tozorakimab or a place…

This completed study tested whether omega-3 fatty acids and vitamin D supplements can improve weight, muscle mass, and fatigue in 45 people with COPD who also have cachexia (severe muscle wasting). Participants took the supplements twice daily for six weeks. The goal was to see i…

This phase 3 trial tested a new triple-combination inhaler (beclometasone, formoterol, and glycopyrrolate) against a standard two-drug inhaler in 1,368 adults with severe COPD. The study measured changes in lung function and breathlessness over 52 weeks. The goal was to see if th…

This study tested two doses of a drug called tozorakimab in over 1,100 adults with COPD who had frequent flare-ups. Participants received either the drug or a placebo as a shot, while continuing their usual inhalers. The main goal was to see if the drug could reduce the number of…

This study tested a new medicine called tozorakimab in over 1,100 adults with COPD who had frequent or severe flare-ups. Participants received either a low or high dose of the drug or a placebo as a shot under the skin, while continuing their usual inhalers. The main goal was to …

This Phase 3 study tested a new inhaler called HL231 in 487 Chinese adults with moderate to very severe COPD. Participants used either HL231 or the active comparator Ultibro once daily for 52 weeks. The main goal was to see if HL231 improved lung function (FEV1) after 26 weeks co…

This study compared two different triple-combination inhalers (BGF and FUV) in 22 people with stable COPD. The goal was to see which one better improves small airway function. Participants used each inhaler for a period and then switched, allowing a direct comparison of their eff…

This study tested whether a bacterial vaccine called MV130, taken daily under the tongue for 12 months, can reduce the number and severity of COPD flare-ups in adults with moderate to severe COPD. A total of 198 participants were randomly assigned to receive either MV130 or a pla…

This study tested a new inhaler (BGF MDI HFO) delivering a triple-drug combination (budesonide, glycopyrronium, formoterol fumarate) against the current inhaler (BGF MDI HFA) in 559 people with moderate to very severe COPD. The main goal was to compare safety over 12 weeks, with …

This study looked at whether a 4-week program of breathing muscle training, aerobic exercise, or both could improve breathing strength, walking ability, and well-being in women with stable COPD. 68 women aged 48-65 with mild-to-moderate COPD took part. The researchers also checke…

This study tested a new breathing support method (HVNI) against standard non-invasive ventilation (NIV) in 66 COPD patients with dangerously high carbon dioxide levels. The goal was to see if HVNI could safely lower carbon dioxide and reduce the need for a breathing tube. Results…

This study looked at two different breathing exercises for people with COPD, a long-term lung disease. 58 adults were split into two groups: one used a device that creates vibrations while breathing out, and the other used a special breathing technique. The goal was to see which …

This study tested a new automatic setting (Auto-EPAP) on a ventilator to see if it could better manage airway blockages during sleep compared to the standard manual setting. It involved 23 adults with conditions like sleep apnea, COPD, or obesity-related breathing problems who al…

This study followed 10 people with moderate to severe COPD in Romania who started taking the inhaler TRIXEO AEROSPHERE. Researchers measured changes in their health status and treatment satisfaction over 3 and 6 months. The goal was to see how the medication works in everyday lif…

This study tested whether L-menthol, a minty compound, can reduce breathlessness and improve exercise ability in people with COPD. Twenty adults with stable COPD cycled while researchers measured their breathing discomfort and endurance. The goal was to see if a simple, natural s…

This study tested whether adding a specific breathing technique called 4-7-8 breathing to standard COPD care can reduce shortness of breath, improve lung function, and boost quality of life. Forty adults with mild to moderate COPD were enrolled. The technique involves breathing i…

This completed observational study looked at 4500 patients admitted to internal medicine wards with heart failure, COPD, or chronic kidney disease. Researchers aimed to identify which other chronic conditions tend to cluster with these diseases, and how those clusters affect pati…

This study looked at how doing a mental task while standing affects balance in people with chronic lung disease (COPD). Researchers compared 36 adults with COPD to healthy volunteers to see if their balance got worse when they had to think at the same time. The goal was to better…

This study looked at whether people with COPD have trouble controlling their knee muscles during everyday tasks that require precise, gentle force. Researchers compared 36 participants (COPD patients and healthy volunteers) as they performed small, controlled leg contractions. Th…

This completed observational study included 123 adults with COPD or asthma. Researchers measured breathing muscle strength using a special device and then tried to predict those results from simpler tests like spirometry and body composition. The goal was to see if doctors could …

This study looked at how well people with COPD can learn to use three different inhaler devices: Diskus, Breezhaler, and Respimat. Twenty-four participants were taught to use each device and then checked for mistakes. The goal is to find better ways to train patients so they get …

This completed study from Mansoura University looked at how low fat-free mass (muscle) affects the outlook for people with COPD. Researchers studied 90 adults aged 40 and older with confirmed COPD. They used breathing tests, a 6-minute walk test, CT scans, and the BODE index to m…

This completed study looked at whether substances in nasal fluid can help doctors objectively measure the severity of respiratory conditions like asthma, COPD, hayfever, and sinusitis. Researchers collected samples from 111 adults (including healthy volunteers) using a small nasa…

This study tested two types of breathing muscle training in 24 people with COPD. One was traditional (using a handheld resistance device while sitting), and the other was functional (integrated into movement). Researchers measured muscle oxygen levels, shortness of breath, and fa…

This study looked at how breathing and swallowing interact in people with severe COPD who were in the hospital for a sudden worsening of their condition. Researchers wanted to see if using a non-invasive breathing machine (NIV) changes this interaction. Sixteen patients were obse…

This study looked at how over 1,600 people's bodies react to different breakfasts, like whole grain vs. refined grain and high-fat vs. high-carb. Researchers measured blood sugar, fats, and other markers after meals to understand why responses vary. The goal is to pave the way fo…

This study looked back at the medical records of 718 adults with COPD in Spain who started taking the triple-combination inhaler Trixeo. Researchers wanted to see how many lung flare-ups (exacerbations) patients had in the year after starting the drug. The goal was to understand …

This completed study used chest MRI scans to look at blood flow in the lungs of 30 people with COPD. The goal was to learn how blood vessels adapt during exercise and how this relates to disease progression. By better understanding these changes, researchers hope to improve care …

This completed Phase 1 study in 30 healthy volunteers looked at how cyclosporine, a drug that blocks certain transporters, affects the amount of CHF6001 (Tanimilast) in the blood. Participants took CHF6001 alone first, then again after taking cyclosporine. The goal was to see if …