CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

This study tested a new inhaled medicine called HL231 in 487 Chinese adults with moderate to very severe COPD. The goal was to see if HL231 works better than an existing inhaler (Ultibro) at improving lung function and reducing flare-ups over 26 to 52 weeks. Participants used the…

This study tested two doses of a drug called tozorakimab in over 1100 adults with COPD who had frequent or severe flare-ups in the past year. Participants continued their usual inhaled treatments and received either the study drug or a placebo as a shot. The main goal was to see …

This study tested whether a bacterial vaccine called MV130, taken daily under the tongue for 12 months, could reduce the number and severity of flare-ups in adults with moderate to severe COPD. Researchers compared it to a placebo in 198 participants and followed them for 18 mont…

This study tested two doses of a drug called tozorakimab in over 1,100 adults with COPD who had frequent flare-ups. Participants were former or current smokers already on standard inhalers. The goal was to see if the drug could safely reduce the number of moderate to severe COPD …

This study compared two different triple-combination inhalers (BGF and FUV) in 22 people with stable COPD. The goal was to see which one better improves small airway function. Participants tried both treatments in a crossover design, and the study measured lung function and safet…

This study tested whether a new version of a common COPD inhaler (BGF) is as safe as the current one. 559 adults with moderate to very severe COPD took the medicine twice a day for 12 weeks, with some continuing for a year. Researchers tracked serious and common side effects to c…

This study tested two breathing support methods in 66 adults with COPD who had dangerously high carbon dioxide levels. One group received high-velocity nasal insufflation (HVNI) and the other received non-invasive ventilation (NIV). The main goal was to see how well each method l…

This study tested a new automatic feature in a home ventilator that adjusts pressure during exhalation to keep the upper airway open. It included 23 adults with conditions like sleep apnea, COPD, or obesity-related breathing problems who already used a ventilator. The goal was to…

This study tested whether L-menthol, a minty compound, can reduce breathlessness and improve exercise ability in people with chronic obstructive pulmonary disease (COPD). Twenty adults with COPD cycled while researchers measured their breathing difficulty and exercise capacity. T…

This study followed 10 adults with moderate to severe COPD in Romania who were newly prescribed the inhaler TRIXEO AEROSPHERE. Researchers wanted to see how patients' health status and treatment satisfaction changed over 3 and 6 months in everyday life. The goal was to understand…

This study looked at two methods to help people with COPD clear mucus from their lungs and breathe easier. 58 adults with COPD used either a device that creates gentle vibrations while they breathe out (OPEP therapy) or a special breathing technique called autogenic drainage for …

This study tested whether adding the 4-7-8 breathing technique to usual care helps people with mild-to-moderate COPD feel less short of breath and improve lung function. Forty adults aged 40-64 took part. Researchers measured shortness of breath, lung capacity, and quality of lif…

This study looked at how blood vessels in the lungs of people with COPD change from rest to exercise. Researchers used MRI scans, a safe imaging method, to measure blood flow in 30 adults aged 40-70 with COPD. The goal was to better understand how the disease affects lung blood v…

This study looked at how doing a mental task (like counting backwards) affects balance in people with chronic lung disease (COPD). 36 volunteers, including those with COPD and healthy adults, had their balance measured while standing still and while thinking. The goal was to see …

This study looked at how breathing and swallowing interact in people with COPD who were in the intensive care unit for a sudden worsening of their condition. Researchers wanted to see if using a breathing machine (non-invasive ventilation) changes this interaction. Sixteen patien…

This completed study looked at whether tiny samples of nasal fluid can help doctors objectively measure how severe respiratory conditions like COPD, asthma, hayfever, and sinusitis are. Researchers compared 111 adults—some healthy and some with these conditions—using a special de…

This study looked at how two different breathing exercises affect muscle oxygen levels in 24 people with COPD. Participants did both a traditional and a functional breathing workout on separate days. Researchers measured muscle oxygen, shortness of breath, and fatigue before and …

This completed study looked at how low fat-free mass (muscle) affects the outlook for people with COPD. Researchers evaluated 90 adults using breathing tests, a 6-minute walk test, and chest CT scans. The goal was to understand if muscle loss is linked to worse disease progressio…

This completed study looked at how over 1,600 people's bodies respond differently to various breakfasts, like whole grain vs. refined grain and high-fat vs. high-carb. Participants ate standardized meals and took blood samples at home to track sugar, fat, and inflammation levels.…

This study looked at how people with COPD learn to use different inhaler devices correctly. 24 participants were observed to see if they made major mistakes when using the inhalers. The goal was to find common errors and improve training so patients get the full benefit of their …

This study looked at how well people with COPD can control the force of their knee muscles during everyday tasks. Researchers compared 36 participants (COPD patients and healthy volunteers) using special signal analysis. The goal was to understand if COPD causes problems with pre…

This study looked at how cyclosporine, a drug that blocks certain transporters, changes the amount of CHF6001 in the blood. Thirty healthy adults took CHF6001 alone and then with cyclosporine to compare drug levels. The goal is to understand potential interactions and guide safe …

This study looked at 718 adults with COPD in Spain who started taking Trixeo Aerosphere, a triple-combination inhaler. Researchers tracked their health records for up to 12 months to see how many lung flare-ups (exacerbations) they had. The goal was to understand the patients' ch…