CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

This study tests an experimental drug called 9MW1911 to see if it can reduce the number of serious breathing flare-ups in people with chronic obstructive pulmonary disease (COPD). About 360 adults aged 40 to 75 with moderate-to-severe COPD and a history of recent flare-ups will r…

This study tests whether using air cleaners at home can reduce flare-ups and improve quality of life for people with COPD. About 770 adults aged 40 and older with COPD and a history of smoking will use either a real air cleaner or a sham device for one year. The goal is to see if…

This study tracks 350 adults with uncontrolled COPD who are starting dupilumab, a medication that helps control inflammation. Over 24 months, researchers will measure changes in quality of life and monitor for side effects. The goal is to see how well dupilumab works in everyday …

This study tests a new treatment using special stem cells from fetal tissue to help people with moderate to severe COPD. The goal is to see if it is safe and can improve lung function and control severe symptoms. About 30 adults aged 40-80 who have not responded well to standard …

This study tests an experimental tablet called AZD6793 in 1,160 adults with moderate to very severe COPD. Participants take one of three doses or a placebo for 24 weeks to see if it safely reduces the number of serious flare-ups. All participants must already be on standard tripl…

This study looks at two ways to manage sedation in COPD patients who need a breathing machine. One group gets no sedation, while the other has their sedation paused each day. The goal is to see which approach helps patients spend more days breathing without the machine. The study…

This study tests an experimental drug called tezepelumab in adults aged 40 to 80 with moderate to very severe COPD. The goal is to see if it can reduce the number of moderate or severe flare-ups compared to a placebo. Participants must have had at least two moderate or one severe…

This study tests an experimental drug called astegolimab in people with COPD who have frequent flare-ups. About 1,290 current or former smokers will receive either the drug or a placebo for 52 weeks. The main goal is to see if the drug reduces the number of moderate to severe COP…

This early-phase study tests a new stem cell therapy called REGEND007 for people with chronic obstructive pulmonary disease (COPD). The treatment uses airway basal cells, which may help repair damaged lung tissue. The study will enroll 12 adults aged 40-80 to check safety and see…

This study tests an experimental drug called tezepelumab in about 990 adults with moderate to very severe COPD. The goal is to see if it can reduce the number of serious flare-ups (exacerbations) compared to a placebo over 76 weeks. Participants must be 40-80 years old, have had …

This study tests whether omalizumab, an allergy drug, can reduce serious flare-ups in people with COPD who also have allergies. About 334 adults over 40 with a history of smoking and COPD will receive injections for 12 months. The goal is to see if the drug lowers the number of C…

This study tests if umbilical cord stem cells can improve lung function and quality of life in people with severe COPD. All 20 participants already receive standard inhaled medications. They will get either stem cells or a placebo added to their treatment and be followed for 12 m…

This study looks at whether treating a common stomach infection called H. pylori can improve symptoms and lung function in people with COPD. Researchers will give H. pylori treatment to 54 adults with both COPD and H. pylori infection, then measure changes in their breathing test…

This study tests a new exercise method for people with moderate to severe COPD. Instead of heavy weights, participants do light arm exercises while wearing a cuff that slightly restricts blood flow. The goal is to see if this approach can safely improve arm strength, daily functi…

This early-stage study tests a new drug, BBT002, in healthy volunteers and people with COPD to see if it is safe and tolerable. Researchers will also look at how the drug moves through the body and whether it shows any signs of helping with COPD symptoms. The study involves 68 pa…

This study tests whether breathing in nitric oxide for one week can help people with moderate-to-severe COPD exercise longer and with less effort. Sixteen adults aged 40-75 who have smoked heavily in the past will take part. The goal is to see if this treatment is safe and improv…

This study looks at how different frequencies of whole body vibration affect lung function, breathing, arm strength, flexibility, heart health, and quality of life. It includes both healthy adults and people with moderate to severe COPD. The goal is to find the best vibration dos…

This study tests whether a device that uses gentle pressure changes to clear mucus and trapped air from the lungs can reduce shortness of breath after walking in people with COPD. About 33 adults who have completed pulmonary rehab will use the active device or a placebo at home f…

This study tests a new program called Mindful-Breath for people with COPD. It combines mindfulness, breathing exercises, and lifestyle coaching through group sessions and text messages. The goal is to see if it helps patients be more active, feel less stressed, and improve their …

This study looks at how common frailty is in older adults with COPD and tests whether the Vivifrail exercise program can improve their physical abilities, daily activities, and quality of life. About 80 people aged 60 and older with stable COPD will take part. The program focuses…

This study tests whether a pulmonary rehabilitation program can help people with COPD who live in rural areas. The program aims to improve breathing, reduce tiredness, and boost quality of life. Researchers will enroll 306 adults aged 40 and older who have been diagnosed with COP…

This study looks at whether a walking exercise program can help people with COPD feel less anxious, depressed, and short of breath, and improve their sleep and quality of life. About 68 adults with COPD will either do walking and resistance band exercises for three months or just…

This study aims to find the best treatment for sudden worsening of COPD (a lung disease). It compares two common steroids, hydrocortisone and prednisolone, in 2,000 adults aged 40 and older. The main goal is to see if one reduces hospital readmissions or deaths within 30 days bet…

This study tests whether a wrist-worn device that counts coughs can predict serious COPD flare-ups before they happen. Fifty adults with COPD will wear the Hyfe monitor and answer weekly symptom questions. The device does not record audio, and doctors will treat patients as usual…

This study looks at whether adding routine physical health checkups to mental health care helps find hidden diseases like diabetes, heart problems, and lung disease in people with serious mental illness. About 2,800 adults in Denmark will get these screenings, and their results w…

This study looks at how the immune system influences disease control in people with inflammatory airway diseases like asthma, COPD, and bronchiectasis. Researchers will collect blood samples, lung function tests, and health questionnaires from 200 participants, including healthy …

This study aims to understand how mucus buildup in the airways affects people with asthma, COPD, and chronic cough. Researchers will use CT scans and other tests to measure mucus in 240 adults and 50 children with these conditions, plus 100 healthy volunteers. The goal is to find…

This study aims to understand how chronic breathlessness differs in people with cancer, COPD, or heart failure by using brain scans (fMRI) and virtual reality. Sixteen adults with persistent breathlessness will undergo an fMRI while experiencing virtual reality, and report their …

This study looks at how different types of social support—like emotional help, practical aid, and companionship—affect the ability of people with COPD to manage their condition. Researchers will survey 111 adults aged 40 and older with COPD, and interview 20 of them to understand…

This study looks at whether a special hospital unit called an Acute Medical Unit (AMU) can provide better care for older adults with sudden illnesses like infections, falls, or COPD flare-ups. Researchers will compare patients who go to the AMU with those who get usual hospital c…

This study looks back at medical records of 1000 adults with COPD who had a special heart test. The goal is to learn more about a condition called pulmonary hypertension, where blood vessels in the lungs are under high pressure. By analyzing past data, researchers hope to better …

This study aims to understand why many people with COPD and asthma do not use their inhalers correctly, and to test new ways to help them stick to their treatment. Researchers will work with 1,000 patients and their healthcare providers, using a special assessment tool and artifi…

This study compares exercise capacity, muscle strength, and quality of life among three groups: people with COPD, people with a less-known lung condition called PRISM, and healthy adults. Researchers will measure walking ability, muscle oxygen levels, and artery stiffness. The go…

This study is not testing a new treatment. Instead, it will collect information from about 500 people in Moscow who have moderate to very severe COPD and frequent exacerbations. Researchers want to learn about their age, lifestyle, medical history, and current treatments to bette…

This study follows 900 adults in Greece who have both chronic obstructive pulmonary disease (COPD) and a heart condition. Researchers will track lung flare-ups, heart complications, hospital visits, and quality of life over two years. The goal is to better understand these patien…

This study looks at how people with chronic lung diseases like COPD and asthma experience breathing difficulty. Some feel severe distress with mild issues, while others notice little even with poor lung function. Researchers will group 950 participants (800 patients and 150 healt…

This study is testing a wearable system called WearME to see if it can accurately measure breathing and activity in people with COPD. Researchers will compare the device's readings to standard lung function tests. The goal is to find a simpler way to monitor COPD at home. The stu…

This study follows about 500 adults with uncontrolled COPD who are taking dupilumab as part of their regular care. Researchers will collect data over 36 months to understand patient characteristics, safety, and how the drug affects symptoms and flare-ups. The goal is to learn mor…

This study tracks 50 COPD patients who have been hospitalized for a sudden worsening of their condition (called an acute exacerbation). Participants wear a device that measures oxygen levels, heart rate, breathing rate, activity, sleep, and skin temperature for three months after…

This study looks at how taking multiple medications affects the health of elderly people with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will survey 2000 patients aged 65 and older in Shaanxi Province, China, over two years. The goal is to…

This study collects blood, airway, and urine samples from up to 2,000 healthy volunteers and people with lung diseases like COPD and pulmonary fibrosis. The goal is to establish normal ranges and understand the genetic changes that lead to lung disease. Participants must be 18 or…

This study is observing 10,000 adults aged 40-80 with COPD to understand how combining Western medicine with traditional Chinese medicine (like tongue and pulse checks) can better manage the disease and its related health problems, such as heart disease and diabetes. Researchers …

This study looks at whether giving extra oxygen during a 6-minute walk test helps people with chronic lung disease walk farther and feel better. About 114 adults with conditions like COPD or lung scarring will do two walking tests—one with their usual oxygen and one with extra ox…