New COPD pill aims to cut dangerous lung attacks

NCT ID NCT07082738

Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Sep 09, 2026 · Updated 5 times

Summary

This study tests an experimental tablet called AZD6793 in adults with moderate to very severe COPD. About 987 participants will take one of two doses of the drug or a placebo for 24 weeks. The goal is to see if the drug can reduce the number of serious flare-ups (exacerbations) compared to a placebo. All participants must already be on standard inhaled triple therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 987 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participant must be ≥40 years of age at the time of signing the informed consent. * Documented primary diagnosis of COPD for at least 12 months prior to enrolment. * Pre-BD FEV1/FVC \< 0.7 at Visit 1 and pre- and post-BD FEV1/FVC \< 0.7, and post-BD FEV1 ≥ 25% to \< 80% of predicted normal at Visit 2. * Documented history of ≥ 2 moderate or ≥ 1 severe COPD exacerbations in the 12 months prior to screening. * Documented stable regimen of inhaled triple maintenance therapy or inhaled dual maintenance therapy for ≥ 3 months prior to screening. * CAT score ≥ 10 at Visit 1. * Current or ex-smokers with a cigarette smoking history of ≥ 10 pack-years. * Participants who are clinically stable and free from an exacerbation of COPD for 4 weeks prior to Visit 1 and are also exacerbation free for at least 4 weeks (28 days) prior to Visit 3 (randomisation). * Negative pregnancy test at Visit 1 and Visit 3 for Women Of Child-Bearing Potential (WOCBP). Exclusion Criteria: * Clinically important pulmonary disease other than COPD (eg, asthma \[current diagnosis per GINA or other accepted guidelines\], active pulmonary infection, clinically significant bronchiectasis when bronchiectasis is the predominant diagnosis, pulmonary fibrosis, cystic fibrosis, hypoventilation syndrome associated with obesity, lung cancer, alpha-1 antitrypsin deficiency or primary ciliary dyskinesia). * Radiological findings suggestive of a respiratory disease other than COPD that is significantly contributing to the participant's respiratory symptoms. * Any unstable disorder, including, but not limited to, CV, gastrointestinal, hepatic, renal, neurological, musculoskeletal, infectious, endocrine, metabolic, haematological, psychiatric disorder, major physical and/or cognitive impairment. * Significant left heart failure. * Unstable angina, acute coronary syndrome/acute myocardial infarction or coronary intervention with percutaneous coronary intervention/coronary artery bypass graft within 6 months of randomisation, uncontrolled arrhythmia, or cardiomyopathy, clinically significant aortic stenosis, or signs of pulmonary oedema or volume overload. * Pulmonary arterial hypertension, either idiopathic or due to connective tissue or thromboembolic disease. * History of another underlying condition that predisposes the participant to infections. * History of ulcerative colitis, Crohn's disease, or microscopic colitis diagnosed by either a gastroenterologist or by histopathology. * Abnormal laboratory findings. * Participants with evidence of active liver disease and/or evidence of chronic liver disease. * Participants with history of HIV infection or who test positive for HIV. * History of lung volume reduction surgery. * Current or history of malignancy within 5 years before the screening visit.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic obstructive pulmonary disease (COPD)

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

320 sites in 23 countries. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

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Birmingham, Alabama, 35205, United States
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Glendale, Arizona, 85306, United States
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Phoenix, Arizona, 85027, United States
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Phoenix, Arizona, 85044, United States
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Phoenix, Arizona, 85051, United States
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Canoga Park, California, 91303, United States
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La Mesa, California, 91942, United States
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Los Angeles, California, 90017, United States
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Newport Beach, California, 92663, United States
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Norco, California, 92860, United States
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Tustin, California, 92780, United States
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Lakewood, Colorado, 80228, United States
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Brandon, Florida, 33511, United States
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Cape Coral, Florida, 33990, United States
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Clearwater, Florida, 33756, United States
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Clearwater, Florida, 33765, United States
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Jacksonville, Florida, 32216, United States
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Lake City, Florida, 32055, United States
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Miami, Florida, 33125, United States
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Miami, Florida, 33155, United States
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Miami, Florida, 33173, United States
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Miami, Florida, 33175, United States
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Miami, Florida, 33182, United States
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Miami Lakes, Florida, 33016, United States
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Naples, Florida, 34102, United States
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Ocala, Florida, 34471, United States
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Ormond Beach, Florida, 32174, United States
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Plantation, Florida, 33324, United States
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Sarasota, Florida, 34239, United States
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Tamarac, Florida, 33321, United States
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Tampa, Florida, 33606, United States
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Tampa, Florida, 33607, United States
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Winter Park, Florida, 32789, United States
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Suwanee, Georgia, 30024, United States
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West Des Moines, Iowa, 50266, United States
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Lexington, Kentucky, 40503, United States
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Zachary, Louisiana, 70791, United States
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Baltimore, Maryland, 21201, United States
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Baltimore, Maryland, 21224, United States
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Burlington, Massachusetts, 01805, United States
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Farmington Hills, Michigan, 48336, United States
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Garden City, Michigan, 48135, United States
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Grand Rapids, Michigan, 49546, United States
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Chesterfield, Missouri, 63005, United States
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Hannibal, Missouri, 63401, United States
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St Louis, Missouri, 63110, United States
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St Louis, Missouri, 63141, United States
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Missoula, Montana, 59808, United States
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Mount Kisco, New York, 10549, United States
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New Bern, North Carolina, 28562, United States
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Cleveland, Ohio, 44106, United States
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Marion, Ohio, 43302, United States
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Oklahoma City, Oklahoma, 73104, United States
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Tulsa, Oklahoma, 74133, United States
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Medford, Oregon, 97504, United States
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Portland, Oregon, 97202, United States
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Camp Hill, Pennsylvania, 17011, United States
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DuBois, Pennsylvania, 15801, United States
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Philadelphia, Pennsylvania, 19114, United States
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Philadelphia, Pennsylvania, 19140, United States
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Pittsburgh, Pennsylvania, 15213, United States
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Scottdale, Pennsylvania, 15683, United States
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Smithfield, Pennsylvania, 15478, United States
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Lancaster, South Carolina, 29720, United States
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Spartanburg, South Carolina, 29303, United States
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Rapid City, South Dakota, 57702, United States
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Chattanooga, Tennessee, 37421, United States
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Franklin, Tennessee, 37067, United States
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Johnson City, Tennessee, 37604, United States
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Boerne, Texas, 78006, United States
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Dallas, Texas, 75254, United States
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Denison, Texas, 75020, United States
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El Paso, Texas, 79902, United States
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Houston, Texas, 77002, United States
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Houston, Texas, 77008, United States
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Houston, Texas, 77030, United States
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TERMINATED

Kingwood, Texas, 77339, United States
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Lewisville, Texas, 75067, United States
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Mansfield, Texas, 76063, United States
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McKinney, Texas, 75069, United States
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Pearland, Texas, 77584, United States
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Colchester, Vermont, 05446, United States
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Norfolk, Virginia, 23504, United States
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Williamsburg, Virginia, 23188, United States
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Morgantown, West Virginia, 26505, United States
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Madison, Wisconsin, 53715, United States
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Alberdi, X5033DCE, Argentina
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CABA, C1426, Argentina
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Ciudad Autónoma de Bs As, C1182ACD, Argentina
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Ciudad de Buenos Aires, 1060, Argentina
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Ciudad de Buenos Aires, C1094AAD, Argentina
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Mar del Plata, 7600, Argentina
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Mar del Plata, B7600GWV, Argentina
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Mendoza, M5500CCG, Argentina
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Ranelagh, 1886, Argentina
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Rosario, 2000, Argentina
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San Miguel de Tucumán, 4000, Argentina
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Cairns, 4870, Australia
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Nedlands, 6009, Australia
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Norwood, 5067, Australia
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Osborne Park, 6017, Australia
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South Brisbane, 4101, Australia
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Wollongong, 2500, Australia
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Dupnitsa, 2600, Bulgaria
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Haskovo, 6300, Bulgaria
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Plovdiv, 4003, Bulgaria
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Sofia, 1756, Bulgaria
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Stara Zagora, 6003, Bulgaria
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Veliko Tarnovo, 5000, Bulgaria
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Yambol, 8600, Bulgaria
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Edmonton, Alberta, T6G 2G3, Canada
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Winnipeg, Manitoba, R3L 1Z5, Canada
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Truro, Nova Scotia, B2N 1L2, Canada
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Ajax, Ontario, L1S 2J5, Canada
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Burlington, Ontario, L7N 3V2, Canada
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Guelph, Ontario, N1H 6J2, Canada
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Hamilton, Ontario, L8L 5G4, Canada
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Stoney Creek, Ontario, L8G 2V6, Canada
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Québec, Quebec, G1V 4G5, Canada
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Saint-Charles-Borromée, Quebec, J6E 2B4, Canada
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Sherbrooke, Quebec, J1H 5N4, Canada
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Trois-Rivières, Quebec, G8T 7A1, Canada
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Trois-Rivières, Quebec, G9A 4P3, Canada
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Victoriaville, Quebec, G6P 3Z8, Canada
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Saskatoon, Saskatchewan, S7N 0W8, Canada
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Chile, 7770484, Chile
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Concepción, 4070057, Chile
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Santiago, 7501126, Chile
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Santiago, 7750495, Chile
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Santiago, 8380453, Chile
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Talca, 3481349, Chile
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Temuco, 4810345, Chile
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Viña del Mar, 2540488, Chile
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Baotou, 014040, China
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Beijing, 100024, China
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Beijing, 100029, China
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Beijing, 101100, China
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Changchun, 130021, China
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Changsha, 410008, China
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Changsha, 410015, China
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Chengdu, 610021, China
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Chengdu, 610041, China
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Chengdu, 610072, China
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Chongqing, 400042, China
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Fuzhou, 350031, China
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Guangzhou, 510163, China
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Guangzhou, 510280, China
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Hangzhou, 310009, China
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Hohhot, 010050, China
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Jinan, 250013, China
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Kunming, 650032, China
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Linhai, 317000, China
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Nanchang, 330006, China
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Nanjing, 210006, China
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Nanning, 530021, China
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Qingdao, 266011, China
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Shanghai, 200025, China
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Shanghai, 200433, China
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Shenyang, 110004, China
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Wuhan, 430030, China
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Wuhan, 430060, China
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Xuzhou, 221000, China
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Zhengzhou, 450003, China
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Aalborg, 9000, Denmark
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Aarhus, 8200, Denmark
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Esbjerg, 6700, Denmark
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Hvidovre, 2650, Denmark
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Odense C, 5000, Denmark
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Roskilde, 4000, Denmark
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WITHDRAWN

Ahrensburg, 22926, Germany
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Bendorf, 56170, Germany
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Berlin, 10119, Germany
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Berlin, 10787, Germany
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Berlin, 10961, Germany
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Berlin, 12157, Germany
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Berlin, 12159, Germany
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Berlin, 13187, Germany
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Darmstadt, 64283, Germany
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Halle, 06108, Germany
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Hanover, D-30173, Germany
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Landsberg, 86899, Germany
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Leipzig, 04347, Germany
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Lübeck, 23552, Germany
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Marburg, 35037, Germany
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Obertshausen, 63179, Germany
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Rosenheim, 83022, Germany
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Schleswig, 24837, Germany
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Wiesbaden, 65183, Germany
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Witten, 58452, Germany
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Athens, 11521, Greece
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Athens, 11527, Greece
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Athens, 17562, Greece
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Ioannina, 45500, Greece
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Thessaloniki, 57001, Greece
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Thessaloniki, 57010, Greece
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Balassagyarmat, 2660, Hungary
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Budapest, 1044, Hungary
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Debrecen, 4032, Hungary
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Edelény, 3780, Hungary
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Encs, 3860, Hungary
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Gödöllő, 2100, Hungary
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Hajdúnánás, 4080, Hungary
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Nyíregyháza-Sóstóhegy, 4481, Hungary
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Pécs, 7635, Hungary
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Szombathely, 9700, Hungary
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Törökbálint, 2045, Hungary
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Belagavi, 590010, India
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Coimbatore, 641028, India
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Dehradun, 248001, India
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Delhi, 110029, India
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Dwārka, 110075, India
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Hyderabad, 500055, India
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Hyderabad, 500068, India
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Kochi, 682018, India
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Mumbai, 400008, India
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Nagpur, 440019, India
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Vijayawada, 520 008, India
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Busto Arsizio, 21052, Italy
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Cuneo, 12100, Italy
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NOT_YET_RECRUITING

Ferrara, 44100, Italy
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Milan, 20122, Italy
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Monza, 20900, Italy
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Naples, 80131, Italy
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Pavia, 27100, Italy
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Roma, 00161, Italy
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Statte, 74010, Italy
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Telese Terme, 82037, Italy
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Chiba, 260-0852, Japan
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Fukuoka, 814-0180, Japan
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Fukushima, 960-1295, Japan
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Ginowan-shi, 901-2214, Japan
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Hachioji-shi, 193-0998, Japan
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Hamamatsu, 431-3192, Japan
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Hiroshima, 734-8530, Japan
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Izumi-shi, 594-0073, Japan
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Kamakura, 247-8533, Japan
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Kanazawa, 920-8650, Japan
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Kasuga-shi, 816-0813, Japan
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Kawasaki-shi, 216-8511, Japan
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Kiyosu-shi, 452-0001, Japan
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Kochi, 780-8077, Japan
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Kōtoku, 136-0075, Japan
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Kumamoto, 861-8520, Japan
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NOT_YET_RECRUITING

Kusatsu-shi, 525-8585, Japan
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Kyoto, 612-8555, Japan
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Maebashi, 371-8511, Japan
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Matsuyama, 790-8524, Japan
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Minoh, 562-0003, Japan
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Minokamo Shi, 505-8510, Japan
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Miura, 238-0111, Japan
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Mizunami-shi, 509-6134, Japan
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Osaka, 545-8586, Japan
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Ōita, 870-0033, Japan
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Sagamihara-shi, 252-0143, Japan
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Sapporo, 063-0005, Japan
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Sasebo-shi, 857-8511, Japan
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Shimotsuga-gun, 321-0293, Japan
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Shinjuku-ku, 160-0023, Japan
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Tachikawa-shi, 190-8531, Japan
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Toon-shi, 791-0281, Japan
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Toyota, 471-0062, Japan
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Ube, 755-8505, Japan
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Yokkaichi-shi, 510-8561, Japan
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Yokohama, 227-8501, Japan
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Yokohama, 245-8575, Japan
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Chihuahua City, 31210, Mexico
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Durango, 34000, Mexico
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Guadalajara, 44100, Mexico
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Guadalajara, 44200, Mexico
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Mexico City, 04100, Mexico
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Mexico City, 14050, Mexico
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Monterrey, 64060, Mexico
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Monterrey, 64460, Mexico
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Monterrey, 64465, Mexico
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NOT_YET_RECRUITING

Monterrey, 64710, Mexico
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Lima, 15024, Peru
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Lima, 15036, Peru
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Lima, 15082, Peru
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Lima, 15088, Peru
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NOT_YET_RECRUITING

Lima, 15102, Peru
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Lima, 15324, Peru
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Lima, LIMA 1, Peru
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Lima, Lima 33, Peru
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ACTIVE_NOT_RECRUITING

Bialystok, 15-044, Poland
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ACTIVE_NOT_RECRUITING

Bydgoszcz, 85-796, Poland
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ACTIVE_NOT_RECRUITING

Chęciny, 26-060, Poland
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ACTIVE_NOT_RECRUITING

Elblag, 82-300, Poland
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ACTIVE_NOT_RECRUITING

Karczew, 05-480, Poland
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ACTIVE_NOT_RECRUITING

Katowice, 40-081, Poland
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ACTIVE_NOT_RECRUITING

Katowice, 40-648, Poland
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Komorniki, 62-052, Poland
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ACTIVE_NOT_RECRUITING

Ksawerów, 95-054, Poland
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ACTIVE_NOT_RECRUITING

Lodz, 92-213, Poland
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ACTIVE_NOT_RECRUITING

Ostróda, 14-100, Poland
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ACTIVE_NOT_RECRUITING

Piaseczno, 05-500, Poland
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TERMINATED

Piaseczno, 05-500, Poland
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ACTIVE_NOT_RECRUITING

Poznan, 60-693, Poland
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ACTIVE_NOT_RECRUITING

Płock, 09-407, Poland
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ACTIVE_NOT_RECRUITING

Rzeszów, 35-205, Poland
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WITHDRAWN

Sosnowiec, 41-208, Poland
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WITHDRAWN

Szczecin, 71-434, Poland
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COMPLETED

Warsaw, 00-719, Poland
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Anyang-si, 14068, South Korea
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Cheongju-si, 28644, South Korea
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Chuncheon, 200-704, South Korea
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Daegu, 42415, South Korea
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Daegu, 42601, South Korea
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Jeonju, 54907, South Korea
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Seongnam-si, 13520, South Korea
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Seoul, 03181, South Korea
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Seoul, 06591, South Korea
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Seoul, 07061, South Korea
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Seoul, 08308, South Korea
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Seoul, 143-729, South Korea
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Seoul, 150-713, South Korea
Research Site
RECRUITING

Wŏnju, 26426, South Korea
Research Site
RECRUITING

Benalmádena, 29631, Spain
Research Site
RECRUITING

Granollers, 08402, Spain
Research Site
RECRUITING

Madrid, 28007, Spain
Research Site
RECRUITING

Málaga, 29010, Spain
Research Site
RECRUITING

Mérida, 06800, Spain
Research Site
RECRUITING

Pozuelo de Alarcón, 28223, Spain
Research Site
RECRUITING

Santander, 39008, Spain
Research Site
RECRUITING

Changhua, 500, Taiwan
Research Site
RECRUITING

Kaohsiung City, 80756, Taiwan
Research Site
RECRUITING

Kaohsiung City, 824, Taiwan
Research Site
RECRUITING

Taichung, 40447, Taiwan
Research Site
RECRUITING

Taichung, 40705, Taiwan
Research Site
RECRUITING

Taichung, 433004, Taiwan
Research Site
RECRUITING

Taipei, 10002, Taiwan
Research Site
RECRUITING

Taipei, 11696, Taiwan
Research Site
RECRUITING

Taoyuan, 333, Taiwan
Research Site
RECRUITING

Yung Kang City, 71044, Taiwan
Research Site
RECRUITING

Adana, 1330, Turkey (Türkiye)
Research Site
RECRUITING

Ankara, 06530, Turkey (Türkiye)
Research Site
RECRUITING

Bursa, 16059, Turkey (Türkiye)
Research Site
RECRUITING

İzmit, 41380, Turkey (Türkiye)
Research Site
RECRUITING

Kayseri, 38039, Turkey (Türkiye)
Research Site
RECRUITING

Mersin, 33343, Turkey (Türkiye)
Research Site
RECRUITING

Chernivtsi, 58029, Ukraine
Research Site
RECRUITING

Ivano-Frankivsk, 76018, Ukraine
Research Site
RECRUITING

Ivano-Frankivsk, 76019, Ukraine
Research Site
RECRUITING

Kyiv, 02002, Ukraine
Research Site
RECRUITING

Kyiv, 02081, Ukraine
Research Site
RECRUITING

Kyiv, 02091, Ukraine
Research Site
RECRUITING

Kyiv, 03037, Ukraine
Research Site
RECRUITING

Kyiv, 03680, Ukraine
Research Site
RECRUITING

Lutsk, 43000, Ukraine
Research Site
RECRUITING

Ternopil, 46000, Ukraine
Research Site
RECRUITING

Uzhhorod, 88018, Ukraine
Research Site
RECRUITING

Bradford, BD9 6RJ, United Kingdom
Research Site
RECRUITING

Cottingham, HU16 5JQ, United Kingdom
Research Site
RECRUITING

Glasgow, G4 0SF, United Kingdom
Research Site
ACTIVE_NOT_RECRUITING

Harrow, HA1 3UJ, United Kingdom
Research Site
RECRUITING

London, EC1M 6BQ, United Kingdom
Research Site
COMPLETED

London, NW3 2QG, United Kingdom
Research Site
RECRUITING

Newcastle upon Tyne, NE1 4LP, United Kingdom
Research Site
RECRUITING

Thetford, IP24 1JD, United Kingdom
Research Site
ACTIVE_NOT_RECRUITING

Wythenshawe, M23 9QZ, United Kingdom
Research Site
RECRUITING

Da Nang, 55000, Vietnam
Research Site
NOT_YET_RECRUITING

Dong Thập, 83000, Vietnam
Research Site
RECRUITING

Hanoi, 100000, Vietnam
Research Site
RECRUITING

Hanoi, 10000, Vietnam
Research Site
RECRUITING

Hà Nội, 100000, Vietnam
Research Site
RECRUITING

Ho Chi Minh City, 700000, Vietnam
Research Site
RECRUITING

Huế, 530000, Vietnam
Research Site
SUSPENDED

Rach Gia, 920000, Vietnam

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