Which steroid works best for COPD attacks? major trial aims to find out

NCT ID NCT06892210

Recruiting now Disease control Sponsor: Copenhagen Respiratory Research Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two steroids, hydrocortisone and prednisolone, in 2000 adults over 40 with COPD flare-ups. The goal is to see which one reduces hospital readmissions and deaths within 30 days. Participants are randomly assigned to one of the two treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hydrocortisone and prednisolone (corticosteroids)
What this could lead to: If it works, this could identify which steroid works best for COPD flare-ups, potentially reducing hospital readmissions and deaths.
What could go wrong: This is a late-stage trial but compares two similar drugs already in use, so a dramatic breakthrough is unlikely. Results may show no meaningful difference.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Contacts and locations

Locations

Amager Hospital
RECRUITING

Copenhagen, Copenhagen City, 2300, Denmark
Bispebjerg Hospital
RECRUITING

Copenhagen, Copenhagen City, 2400, Denmark
Bornholm Hospital
RECRUITING

Rønne, Bornholm, 3700, Denmark
Frederiksberg Hospital
RECRUITING

Frederiksberg, Copenhagen City, 2000, Denmark
Gentofte Hospital
RECRUITING

Hellerup, Copenhagen City, 2900, Denmark
Herlev Hospital
RECRUITING

Herlev, Copnhagen Surroundings, 2730, Denmark
Holbæk Sygehus
RECRUITING

Holbæk, Region Sjælland, 4300, Denmark
Hvidovre Hospital
RECRUITING

Hvidovre, Copnhagen Surroundings, 2650, Denmark
Nordsjællands Hospital
RECRUITING

Hillerød, North Zealand, 3400, Denmark
Næstved Sygehus
RECRUITING

Næstved, Region Sjælland, 4700, Denmark
Ringsted Sygehus
RECRUITING

Ringsted, Region Sjælland, 4100, Denmark
Slagelse Sygehus
RECRUITING

Slagelse, Region Sjælland, 4200, Denmark
University Hospital of Region Zealand, Køge
RECRUITING

Køge, Region Sjælland, 4600, Denmark
University Hospital of Region Zealand, Roskilde
RECRUITING

Roskilde, Region Sjælland, 4000, Denmark

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