Can a simple air cleaner ease COPD symptoms?

NCT ID NCT06376994

Recruiting now Disease control Sponsor: JHSPH Center for Clinical Trials Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 31, 2026 · Updated 4 times

Summary

This study tests whether placing two high-efficiency air cleaners in the homes of 770 people with COPD can reduce flare-ups and improve quality of life over a year. Participants receive either active cleaners that remove particles and gases, or sham cleaners that look and sound the same but don't filter. The goal is to see if cleaner indoor air helps manage this chronic lung disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HEPA and activated carbon air cleaners
What this could lead to: If it works, this could show that improving indoor air quality reduces COPD symptoms and flare-ups, offering a simple, non-drug way to manage the disease.
What could go wrong: This is a large phase 3 trial, but air cleaners may not significantly affect COPD outcomes if outdoor exposure or other triggers dominate. The sham devices mimic real ones, so blinding is good, but the benefit may be modest.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Contacts and locations

Locations

Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Dartmouth Hitchcock
RECRUITING

Lebanon, New Hampshire, 03756, United States
Johns Hopkins
RECRUITING

Baltimore, Maryland, 21224, United States
Reading Hospital
RECRUITING

West Reading, Pennsylvania, 19611, United States
Tidal Health
RECRUITING

Salisbury, Maryland, 21801, United States
University of Alabama, Lung Health Center
RECRUITING

Birmingham, Alabama, 35233, United States
University of California, Los Angeles
RECRUITING

Los Angeles, California, 90095, United States
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States
University of Maryland
RECRUITING

Baltimore, Maryland, 21201, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States

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