Mucus mystery: new study aims to uncover role of airway blockages in lung disease

NCT ID NCT06858748

Recruiting now Knowledge-focused Sponsor: McMaster University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This observational study will use CT scans to measure mucus plugging in the airways of people with asthma, COPD, or chronic cough, and compare them to healthy volunteers. Researchers hope to understand how mucus changes over time and find biomarkers that could guide treatment. The study will enroll 240 adults and 50 children with lung disease, plus 100 healthy adults, and follow them for two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help doctors better understand how mucus affects lung diseases and guide more personalized treatments.
What could go wrong: This is an observational study, not a treatment trial. It will not directly test any new therapy, and results may take years to influence clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

asthma Chronic Cough chronic obstructive pulmonary disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTHMA CHRONIC COUGH (CC) CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Contacts and locations

Locations

Quebec Heart and Lung Institute - Laval University
NOT_YET_RECRUITING

Québec, Quebec, G1V 4G5, Canada
Robarts Research Institute
NOT_YET_RECRUITING

London, Ontario, N6A 5B7, Canada
St. Joseph's Healthcare Hamilton
RECRUITING

Hamilton, Ontario, L8N 4A6, Canada
St. Paul's Hospital
NOT_YET_RECRUITING

Vancouver, British Columbia, V6Z 1Y6, Canada
The Ottawa Hospital
NOT_YET_RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
Université de Sherbrooke
NOT_YET_RECRUITING

Sherbrooke, Quebec, J1H 5N4, Canada

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