Could a daily Under-the-Tongue vaccine tame COPD flare-ups?
NCT ID NCT01842360
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a bacterial vaccine called MV130, taken daily under the tongue for 12 months, can reduce the number and severity of COPD flare-ups in adults with moderate to severe COPD. A total of 198 participants were randomly assigned to receive either MV130 or a placebo. Researchers tracked flare-ups, healthcare use, and quality of life over 18 months to see if the vaccine helps control the disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
MV130 (a bacterial vaccine containing killed bacteria)
What this could lead to
If it works, this could provide a new way to reduce COPD flare-ups and improve quality of life for people with moderate to severe COPD.
What could go wrong
This is a mid-stage trial with only 198 participants, so results may not apply to everyone. The vaccine may not reduce flare-ups better than a placebo, and side effects are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hospital Clínico San Carlos
Madrid, 28040, Spain
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Hospital General Universitario Gregorio Marañón
Madrid, 28007, Spain
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Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
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Hospital Universitario Infanta Leonor
Madrid, 28031, Spain
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Hospital Universitario La Paz
Madrid, 28046, Spain
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Hospital Universitario de Torrejón
Torrejón de Ardoz, Madrid, 28850, Spain
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Hospital Universitario de Vic
Vic, Barcelona, 08500, Spain