Could a daily Under-the-Tongue vaccine tame COPD flare-ups?

NCT ID NCT01842360

Completed Disease control Sponsor: Inmunotek S.L. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a bacterial vaccine called MV130, taken daily under the tongue for 12 months, can reduce the number and severity of COPD flare-ups in adults with moderate to severe COPD. A total of 198 participants were randomly assigned to receive either MV130 or a placebo. Researchers tracked flare-ups, healthcare use, and quality of life over 18 months to see if the vaccine helps control the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MV130 (a bacterial vaccine containing killed bacteria)
What this could lead to: If it works, this could provide a new way to reduce COPD flare-ups and improve quality of life for people with moderate to severe COPD.
What could go wrong: This is a mid-stage trial with only 198 participants, so results may not apply to everyone. The vaccine may not reduce flare-ups better than a placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Contacts and locations

Locations

Hospital Clínico San Carlos

Madrid, 28040, Spain
Hospital General Universitario Gregorio Marañón

Madrid, 28007, Spain
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Infanta Leonor

Madrid, 28031, Spain
Hospital Universitario La Paz

Madrid, 28046, Spain
Hospital Universitario de Torrejón

Torrejón de Ardoz, Madrid, 28850, Spain
Hospital Universitario de Vic

Vic, Barcelona, 08500, Spain

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