New opioid aims to cut Post-Surgery nausea without sacrificing pain relief
NCT ID NCT07691086
First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time
Summary
This study compares two painkillers—tegileridine and sufentanil—given as a single shot after laparoscopic surgery in people at high risk of postoperative nausea and vomiting (PONV). The goal is to see if tegileridine, a newer opioid designed to cause fewer side effects, can provide effective pain relief while reducing nausea and vomiting within the first 24 hours after surgery. The trial includes 800 adults aged 18–75 with an Apfel score of 3 or higher, indicating high PONV risk. Researchers will also monitor other side effects like itching, dizziness, and breathing problems.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tegileridine fumarate injection
- What this could lead to
- If tegileridine works better, it could offer a way to manage pain after surgery with less nausea and vomiting, improving recovery and comfort for high-risk patients.
- What could go wrong
- This is an observational study, not a randomized controlled trial, so results may be less definitive. Tegileridine is still being studied, and its benefits over existing opioids are not yet proven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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