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Can a routine surgical step prevent ureter injuries in hysterectomy?

NCT ID NCT07774858

Disease control Sponsor: ClinAmygate Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 19, 2026 · Last updated Aug 27, 2026 · Updated 3 times

Summary

This trial asks whether routinely identifying and freeing the ureters before cutting uterine vessels during laparoscopic hysterectomy reduces the chance of ureter injury compared with doing so only when specific problems arise. It will include thousands of women having the surgery for benign conditions. The main measure is how often ureter injuries occur within 90 days after surgery, with other outcomes like operative time and complications also tracked.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Routine bilateral ureterolysis (a surgical step to identify and protect the ureters) compared with selective ureterolysis performed only when specific safety concerns arise.
What this could lead to
If routine ureterolysis proves better, it could become the standard approach in laparoscopic hysterectomies, potentially reducing the risk of ureter injury and improving patient safety.
What could go wrong
The trial is large but the outcome depends on surgical skill and patient variability; routine dissection might increase operative time or bleeding without reducing injury risk.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 35,000 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Mar 2033

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

35 to 70 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Women aged ≥18 years. * Scheduled for total laparoscopic hysterectomy for a benign gynecological condition. * Able and willing to provide written informed consent. * Considered medically suitable for laparoscopic surgery. Exclusion Criteria: * Suspected or confirmed gynecological malignancy. * Known congenital urinary tract anomaly or pre-existing ureteric obstruction, stricture, fistula, or injury. * Previous ureteric reconstruction or current ureteric stent. * Planned concomitant urological surgery involving the ureter or bladder. * Emergency hysterectomy. * Planned subtotal, vaginal, or abdominal hysterectomy. * Inability to provide informed consent.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hysterectomy Laparoscopic surgery

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

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    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Obstetrics & Gynaecology Department Faculty of Medicine, Cairo University | Kasr Al Ainy Hospital

    Cairo, Cairo Governorate, 11472, Egypt

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