Less may be more: smaller thyroid surgery tested against total removal
NCT ID NCT07274605
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two types of surgery for people with early-stage thyroid cancer located in the isthmus (the middle part of the thyroid). One group will have a smaller surgery called extended isthmusectomy, which removes only the tumor and nearby lymph nodes. The other group will have total thyroidectomy, which removes the entire thyroid gland. The goal is to see if the smaller surgery works just as well at preventing cancer from coming back, while possibly causing fewer long-term side effects. About 520 adults with low-risk thyroid cancer will take part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
surgery (extended isthmusectomy or total thyroidectomy)
What this could lead to
If successful, this could show that a smaller surgery is enough for certain thyroid cancers, reducing complications like permanent hormone dependence and nerve damage.
What could go wrong
This is a non-inferiority trial, so it may only confirm that the smaller surgery is not worse, not necessarily better. Also, results may not apply to more aggressive or advanced cancers.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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2nd Affiliated Hospital, School of Medicine, Zhejiang University, China
Hangzhou, Zhejiang, 310000, China