Less may be more: smaller thyroid surgery tested against total removal
NCT ID NCT07274605
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two types of surgery for people with early-stage thyroid cancer located in the isthmus (the middle part of the thyroid). One group will have a smaller surgery called extended isthmusectomy, which removes only the tumor and nearby lymph nodes. The other group will have total thyroidectomy, which removes the entire thyroid gland. The goal is to see if the smaller surgery works just as well at preventing cancer from coming back, while possibly causing fewer long-term side effects. About 520 adults with low-risk thyroid cancer will take part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- surgery (extended isthmusectomy or total thyroidectomy)
- What this could lead to
- If successful, this could show that a smaller surgery is enough for certain thyroid cancers, reducing complications like permanent hormone dependence and nerve damage.
- What could go wrong
- This is a non-inferiority trial, so it may only confirm that the smaller surgery is not worse, not necessarily better. Also, results may not apply to more aggressive or advanced cancers.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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2nd Affiliated Hospital, School of Medicine, Zhejiang University, China
Hangzhou, Zhejiang, 310000, China
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Other studies related to the condition(s) this trial covers.
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