Can an immune booster make radioiodine more effective against thyroid cancer?

NCT ID NCT03215095

Ongoing Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This trial is testing whether adding the immunotherapy drug durvalumab to standard radioiodine treatment can help people with recurrent or metastatic thyroid cancer. The study includes patients whose tumors still absorb iodine, as seen on scans. The goal is to see if the combination is safe and whether it can shrink tumors or slow the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: durvalumab (an immunotherapy drug) combined with radioiodine (a radioactive treatment)
What this could lead to: If it works, this combination could offer a new treatment option for people with advanced thyroid cancer that has spread or come back.
What could go wrong: This is a very early, small study focused on safety, so it may not show clear benefit. The combination could also cause side effects from the immune system or radiation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

thyroid cancer thyroid gland follicular carcinoma Thyroid Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

THYROID CANCER

Contacts and locations

Locations

Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States

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