New drug combo aims to beat hard-to-treat bone infections

This study tests whether adding a bone-strengthening drug (bisphosphonate) to a standard antibiotic (vancomycin) can better control chronic bone infections that are hard to treat. About 280 adults with a specific type of bone infection will be randomly assigned to get either the combination or the antibiotic alone. The main goal is to see if the infection is under control after 6 months, based on normal temperature, healed wounds, normal blood tests, and new bone growth on X-rays.