Light therapy could replace surgery for cervical precancer

NCT ID NCT07306260

Not yet recruiting Disease control Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares a light-activated gel treatment (ALA-PDT) to standard surgery (LEEP) for women with high-grade cervical precancer (HSIL/CIN2). About 560 women will receive either the gel plus red light therapy or surgery. The goal is to see if the gel treatment works as well as surgery, with fewer side effects and less impact on fertility.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ALA-PDT (aminolevulinic acid photodynamic therapy)
What this could lead to: If it works, this could offer a less invasive, tissue-sparing alternative to surgery for treating cervical precancerous lesions, potentially reducing side effects and preserving fertility.
What could go wrong: This is a non-randomized study, so results may be less reliable. The treatment requires multiple sessions, and it may not be as effective as surgery in the long term. HPV clearance is not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cervical intraepithelial neoplasia grade 2/3 cervical squamous intraepithelial neoplasia human papilloma virus infection squamous cell intraepithelial neoplasia Squamous Intraepithelial Lesions

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CIN 2 HPV (HUMAN PAPILLOMAVIRUS)-ASSOCIATED HSIL, HIGH GRADE SQUAMOUS INTRAEPITHELIAL LESION PHOTODYNAMIC THERAPY (PDT)

Contacts and locations

Locations

First Affiliated Hospital of Ningbo University

Ningbo, Zhejiang, China
First People's Hospital of Hangzhou

Hangzhou, Zhejiang, China
Hangzhou Linping District first People's Hospital

Hangzhou, Zhejiang, China
Shaoxing People's Hospital

Shaoxing, Zhejiang, China
Women's Hospital School Of Medicine Zhejiang University

Hangzhou, Zhejiang, 310000, China

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