Cervical intraepithelial neoplasia grade 2/3

This phase 1 trial tests a DNA vaccine designed to target HPV16, a virus that can cause high-grade cervical lesions (CIN2/3). The vaccine is given by injection into the muscle followed by a mild electrical pulse to help cells take up the DNA. The study includes both HIV-negative …

This phase 2 trial tests a DNA vaccine called PVX4 in 138 women with HPV16-related high-grade cervical dysplasia (CIN2/3). The vaccine is given as a shot with a small electrical pulse to help it enter cells. The goal is to see if it can clear the virus and make abnormal cervical …

This study looks at whether giving the HPV vaccine to women over 45 who still have the virus after treatment for high-grade cervical lesions can help clear the virus faster. About 85 women will either get the vaccine or be observed without it. The goal is to see if the vaccine in…

This study in El Salvador tests a new thermal ablation device (IRIS™) to treat cervical precancer and an AI algorithm to help decide who needs treatment. About 5,000 HPV-positive women aged 30-49 will receive the treatment and be followed for one year to see if the precancer is c…

This phase II trial is testing whether the immunotherapy drug pembrolizumab (Keytruda) can treat high-grade cervical precancer (CIN 2/3 or carcinoma in situ). The study will enroll 25 women and measure how many have a complete response at 6 months. The goal is to see if this drug…

This study tests a supplement called Papillex® to see if it can help reverse abnormal cervical cells caused by HPV. Researchers will compare Papillex® to a placebo in 60 women with mild to moderate cervical changes (CIN 1 or 2). Participants take the supplement daily for 180 days…

This study looks at whether giving the 9vHPV (Gardasil-9) vaccine to women who already have HPV16 or 18 can reduce the virus's ability to infect others. Researchers will measure viral activity in cervical, anal, and oral samples before and after vaccination. The goal is to see if…

This early-phase study is testing whether fenofibrate, a drug normally used to lower cholesterol, can help treat HPV-related cervical cancer and high-grade cervical dysplasia. Researchers will give the drug to 24 adults before their planned surgery and then examine tissue samples…

This phase II trial tests whether artesunate, a drug originally used for malaria, can reverse cervical pre-cancer (CIN2/3) when given as a vaginal insert. About 78 women with high-grade cervical lesions will receive either artesunate or a placebo for three 5-day cycles. The main …

This early study tests a new CRISPR gene therapy (BD114) in 12 women with high-grade cervical lesions caused by HPV-16. The therapy is injected directly into the lesion to disable the virus's cancer-causing genes. The main goals are to check safety and see if the lesions clear up…

This study is testing a new, affordable AI system to screen for cervical cancer in low- and middle-income countries. The AI analyzes urine samples and cervical images to detect high-risk HPV and precancerous changes. About 3,200 unscreened women aged 25-49 in Zimbabwe will take p…

This study evaluates a same-day cervical cancer screening approach for women in Cameroon. Participants first collect their own sample for HPV testing, and if positive, they receive a digital cytology exam on the same day to determine if further treatment is needed. The goal is to…

This study is testing a new, low-cost screening tool for cervical cancer that uses artificial intelligence to analyze digital images of the cervix. It does not require a lab and can be used at the point of care. The goal is to see if this AI tool can accurately detect precancerou…

This study in Honduras tests a new way to prevent cervical cancer using a self-collected HPV test that gives results in under an hour, combined with AI-powered imaging. 5,000 women will participate to see if this same-day screening-and-treatment approach is accurate, feasible, an…

This study follows 300 women aged 18–40 with severe cervical precancer (CIN 2 or 3) to see how often these lesions regress on their own or after surgery. Researchers will track HPV and Pap test results to identify factors that predict healing. The goal is to create a model that h…

This study is testing whether liquid biopsies (blood tests that look for bits of HPV and tumor DNA) can help doctors monitor treatment and spot early signs of cancer returning in people with HPV-related cervical and oropharyngeal cancers. Researchers will follow 480 participants …

This study will collect blood and tumor samples from 1,100 people with various cancers, including head and neck, ovarian, cervical, lung, and brain cancers. Researchers want to learn how immune cells called T cells behave in these tumors. The goal is to better understand why some…