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HPV DNA test could slash cervical cancer deaths in High-Risk populations

NCT ID NCT02956031

Recruiting now Diagnosis Sponsor: University of Pretoria Source: ClinicalTrials.gov ↗

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This study evaluates whether an HPV DNA test can more accurately detect pre-cancerous cervical changes than standard Pap smears in 1,500 women in South Africa, including those with and without HIV. Participants undergo HPV testing, followed by colposcopy and biopsy if needed. The goal is to see if this approach improves early detection and could be used for national screening programs.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
HPV DNA test
What this could lead to
If successful, this screening method could reduce cervical cancer deaths by catching pre-cancer earlier, especially in regions with high HIV rates.
What could go wrong
This is a diagnostic study, not a treatment trial. The screening test may still miss some cases or lead to unnecessary follow-up procedures.

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Conditions

The condition(s) this trial relates to.

cervical cancer cervical intraepithelial neoplasia grade 2/3 cervical squamous intraepithelial neoplasia cervix disorder squamous cell intraepithelial neoplasia Squamous Intraepithelial Lesions Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL CANCER CIN2 HIGH GRADE SIL

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Steve Biko Academic Hospital

    RECRUITING

    Pretoria, Gauteng, South Africa

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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